Top cofit genes for b2264 from Escherichia coli BW25113

menD: 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase (NCBI)
SEED: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (EC 2.2.1.9)
KEGG: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b2260	menE	O-succinylbenzoic acid--CoA ligase (NCBI)	0.92	0.63
2	b2261	menC	O-succinylbenzoate synthase (NCBI)	0.90	0.52
3	b2262	menB	naphthoate synthase (NCBI)	0.92	0.31
4	b4039	ubiC	chorismate lyase (VIMSS)	no	0.30
5	b3289	rsmB	16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent (NCBI)	0.38	0.30
6	b4140	b4140	orf, hypothetical protein (VIMSS)	no	0.28
7	b1255	yciC	hypothetical protein (NCBI)	no	0.27
8	b2775	yqcE	predicted transporter (NCBI)	no	0.27
9	b3038	ygiC	predicted enzyme (NCBI)	0.56	0.27
10	b2263	yfbB	predicted peptidase (NCBI)	0.85	0.26
11	b3423	glpR	DNA-binding transcriptional repressor (NCBI)	no	0.26
12	b4175	hflC	modulator for HflB protease specific for phage lambda cII repressor (NCBI)	0.47	0.26
13	b1753	ynjA	hypothetical protein (NCBI)	no	0.25
14	b4174	hflK	modulator for HflB protease specific for phage lambda cII repressor (NCBI)	0.44	0.25
15	b2952	yggT	predicted inner membrane protein (NCBI)	no	0.25
16	b3037	ygiB	conserved outer membrane protein (RefSeq)	no	0.25
17	b3424	glpG	predicted intramembrane serine protease (NCBI)	no	0.25
18	b4241	treR	trehalose repressor (NCBI)	0.45	0.25
19	b1256	ompW	outer membrane protein W (NCBI)	no	0.24
20	b0143	pcnB	poly(A) polymerase I (VIMSS)	0.34	0.24

Or look for negative cofitness