Top cofit genes for b2026 from Escherichia coli BW25113

hisI: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)
SEED: Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) / Phosphoribosyl-ATP pyrophosphatase (EC 3.6.1.31)
KEGG: phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b2020	hisD	histidinol dehydrogenase (NCBI)	0.99	0.96
2	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.97	0.96
3	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.99	0.95
4	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	0.99	0.95
5	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.98	0.95
6	b3008	metC	cystathionine beta-lyase (NCBI)	0.98	0.95
7	b3772	ilvA	threonine dehydratase (NCBI)	0.98	0.95
8	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.99	0.95
9	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.99	0.94
10	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.98	0.94
11	b0074	leuA	2-isopropylmalate synthase (NCBI)	0.97	0.94
12	b0073	leuB	3-isopropylmalate dehydrogenase (VIMSS)	0.99	0.94
13	b0243	proA	gamma-glutamyl phosphate reductase (NCBI)	0.99	0.94
14	b2021	hisC	histidinol-phosphate aminotransferase (NCBI)	0.98	0.94
15	b2750	cysC	adenylylsulfate kinase (NCBI)	0.95	0.94
16	b0071	leuD	isopropylmalate isomerase small subunit (NCBI)	0.99	0.93
17	b0242	proB	gamma-glutamyl kinase (NCBI)	0.99	0.93
18	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.96	0.93
19	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	1.00	0.93
20	b2414	cysK	cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI)	0.92	0.93

Or look for negative cofitness