Top cofit genes for b2024 from Escherichia coli BW25113

hisA: N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS)
SEED: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16)
KEGG: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.98	0.94
2	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.98	0.94
3	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.98	0.94
4	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.97	0.94
5	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	0.99	0.94
6	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.97	0.94
7	b2020	hisD	histidinol dehydrogenase (NCBI)	0.99	0.93
8	b0073	leuB	3-isopropylmalate dehydrogenase (VIMSS)	0.98	0.93
9	b0074	leuA	2-isopropylmalate synthase (NCBI)	0.98	0.93
10	b2021	hisC	histidinol-phosphate aminotransferase (NCBI)	0.99	0.93
11	b0243	proA	gamma-glutamyl phosphate reductase (NCBI)	0.98	0.92
12	b0242	proB	gamma-glutamyl kinase (NCBI)	0.98	0.92
13	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.98	0.92
14	b0071	leuD	isopropylmalate isomerase small subunit (NCBI)	0.97	0.92
15	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.96	0.92
16	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	0.98	0.92
17	b3772	ilvA	threonine dehydratase (NCBI)	0.97	0.92
18	b2023	hisH	imidazole glycerol phosphate synthase subunit HisH (NCBI)	0.99	0.92
19	b3281	aroE	dehydroshikimate reductase, NAD(P)-binding (NCBI)	0.96	0.91
20	b2599	pheA	fused chorismate mutase P/prephenate dehydratase (NCBI)	0.97	0.91

Or look for negative cofitness