Top cofit genes for b2022 from Escherichia coli BW25113

hisB: imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)
SEED: Histidinol-phosphatase (EC 3.1.3.15) / Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)
KEGG: imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.99	0.98
2	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.99	0.98
3	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.98	0.98
4	b2020	hisD	histidinol dehydrogenase (NCBI)	0.99	0.97
5	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.99	0.97
6	b2021	hisC	histidinol-phosphate aminotransferase (NCBI)	0.99	0.97
7	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	0.98	0.97
8	b0074	leuA	2-isopropylmalate synthase (NCBI)	0.99	0.96
9	b0073	leuB	3-isopropylmalate dehydrogenase (VIMSS)	0.99	0.96
10	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.99	0.96
11	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	0.99	0.96
12	b0071	leuD	isopropylmalate isomerase small subunit (NCBI)	0.98	0.96
13	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.97	0.95
14	b3772	ilvA	threonine dehydratase (NCBI)	0.98	0.95
15	b2023	hisH	imidazole glycerol phosphate synthase subunit HisH (NCBI)	0.99	0.95
16	b0242	proB	gamma-glutamyl kinase (NCBI)	0.99	0.95
17	b0243	proA	gamma-glutamyl phosphate reductase (NCBI)	0.98	0.94
18	b2024	hisA	N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS)	0.98	0.94
19	b2026	hisI	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)	0.98	0.94
20	b2599	pheA	fused chorismate mutase P/prephenate dehydratase (NCBI)	0.97	0.93

Or look for negative cofitness