Top cofit genes for b2021 from Escherichia coli BW25113

hisC: histidinol-phosphate aminotransferase (NCBI)
SEED: Histidinol-phosphate aminotransferase (EC 2.6.1.9)
KEGG: histidinol-phosphate aminotransferase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b2020	hisD	histidinol dehydrogenase (NCBI)	0.99	0.97
2	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.99	0.97
3	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.99	0.97
4	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.99	0.97
5	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.99	0.97
6	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.99	0.95
7	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	0.99	0.95
8	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.98	0.95
9	b0074	leuA	2-isopropylmalate synthase (NCBI)	0.99	0.95
10	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	0.99	0.95
11	b0073	leuB	3-isopropylmalate dehydrogenase (VIMSS)	0.98	0.95
12	b0071	leuD	isopropylmalate isomerase small subunit (NCBI)	0.98	0.95
13	b3772	ilvA	threonine dehydratase (NCBI)	0.98	0.94
14	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.97	0.94
15	b2026	hisI	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)	0.98	0.94
16	b2023	hisH	imidazole glycerol phosphate synthase subunit HisH (NCBI)	0.99	0.94
17	b0243	proA	gamma-glutamyl phosphate reductase (NCBI)	0.98	0.93
18	b0242	proB	gamma-glutamyl kinase (NCBI)	0.98	0.93
19	b3281	aroE	dehydroshikimate reductase, NAD(P)-binding (NCBI)	0.97	0.93
20	b3389	aroB	3-dehydroquinate synthase (NCBI)	0.91	0.93

Or look for negative cofitness