Top cofit genes for b2020 from Escherichia coli BW25113

hisD: histidinol dehydrogenase (NCBI)
SEED: Histidinol dehydrogenase (EC 1.1.1.23)
KEGG: histidinol dehydrogenase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.99	0.97
2	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	1.00	0.97
3	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.98	0.97
4	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.98	0.97
5	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.99	0.97
6	b2021	hisC	histidinol-phosphate aminotransferase (NCBI)	0.99	0.97
7	b0074	leuA	2-isopropylmalate synthase (NCBI)	0.98	0.96
8	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	0.99	0.96
9	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.99	0.96
10	b0073	leuB	3-isopropylmalate dehydrogenase (VIMSS)	0.99	0.96
11	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	0.99	0.96
12	b2026	hisI	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)	0.99	0.96
13	b0071	leuD	isopropylmalate isomerase small subunit (NCBI)	0.99	0.95
14	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.97	0.95
15	b3772	ilvA	threonine dehydratase (NCBI)	0.99	0.94
16	b0243	proA	gamma-glutamyl phosphate reductase (NCBI)	0.99	0.94
17	b0242	proB	gamma-glutamyl kinase (NCBI)	0.98	0.94
18	b2023	hisH	imidazole glycerol phosphate synthase subunit HisH (NCBI)	0.99	0.94
19	b2750	cysC	adenylylsulfate kinase (NCBI)	0.95	0.94
20	b2762	cysH	phosphoadenosine phosphosulfate reductase (NCBI)	0.97	0.93

Or look for negative cofitness