Top cofit genes for b0523 from Escherichia coli BW25113

purE: phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI)
SEED: Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)
KEGG: 5-(carboxyamino)imidazole ribonucleotide mutase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b2557	purL	phosphoribosylformylglycinamidine synthase (NCBI)	0.97	0.96
2	b4005	purD	phosphoribosylamine--glycine ligase (NCBI)	0.97	0.95
3	b4006	purH	bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI)	0.99	0.95
4	b2499	purM	phosphoribosylaminoimidazole synthetase (NCBI)	0.98	0.95
5	b2312	purF	amidophosphoribosyltransferase (NCBI)	0.97	0.95
6	b0522	purK	phosphoribosylaminoimidazole carboxylase (NCBI)	0.97	0.93
7	b2476	purC	phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI)	0.97	0.92
8	b0945	pyrD	dihydroorotate dehydrogenase (NCBI)	0.96	0.90
9	b1062	pyrC	dihydroorotase (NCBI)	0.96	0.90
10	b3642	pyrE	orotate phosphoribosyltransferase (NCBI)	0.95	0.88
11	b1281	pyrF	orotidine 5'-phosphate decarboxylase (NCBI)	0.95	0.88
12	b4245	pyrB	aspartate carbamoyltransferase catalytic subunit (NCBI)	0.95	0.85
13	b0033	carB	carbamoyl-phosphate synthase large subunit (NCBI)	0.96	0.84
14	b4388	serB	3-phosphoserine phosphatase (NCBI)	0.79	0.84
15	b0032	carA	carbamoyl-phosphate synthase small subunit (NCBI)	0.95	0.84
16	b0907	serC	phosphoserine aminotransferase (NCBI)	0.83	0.83
17	b2329	aroC	chorismate synthase (NCBI)	0.88	0.83
18	b2913	serA	D-3-phosphoglycerate dehydrogenase (NCBI)	0.88	0.82
19	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.92	0.82
20	b0003	thrB	homoserine kinase (NCBI)	0.90	0.81

Or look for negative cofitness