Top cofit genes for b0522 from Escherichia coli BW25113

purK: phosphoribosylaminoimidazole carboxylase (NCBI)
SEED: Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)
KEGG: 5-(carboxyamino)imidazole ribonucleotide synthase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b4006	purH	bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI)	0.98	0.96
2	b2557	purL	phosphoribosylformylglycinamidine synthase (NCBI)	0.98	0.96
3	b4005	purD	phosphoribosylamine--glycine ligase (NCBI)	0.98	0.96
4	b2312	purF	amidophosphoribosyltransferase (NCBI)	0.98	0.95
5	b2499	purM	phosphoribosylaminoimidazole synthetase (NCBI)	0.98	0.95
6	b0523	purE	phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI)	0.97	0.93
7	b2476	purC	phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI)	0.95	0.92
8	b1062	pyrC	dihydroorotase (NCBI)	0.95	0.89
9	b0945	pyrD	dihydroorotate dehydrogenase (NCBI)	0.96	0.89
10	b3642	pyrE	orotate phosphoribosyltransferase (NCBI)	0.96	0.89
11	b1281	pyrF	orotidine 5'-phosphate decarboxylase (NCBI)	0.95	0.87
12	b4245	pyrB	aspartate carbamoyltransferase catalytic subunit (NCBI)	0.96	0.86
13	b0033	carB	carbamoyl-phosphate synthase large subunit (NCBI)	0.98	0.85
14	b0032	carA	carbamoyl-phosphate synthase small subunit (NCBI)	0.99	0.84
15	b4388	serB	3-phosphoserine phosphatase (NCBI)	0.86	0.84
16	b0003	thrB	homoserine kinase (NCBI)	0.95	0.84
17	b2329	aroC	chorismate synthase (NCBI)	0.89	0.83
18	b0004	thrC	threonine synthase (NCBI)	0.94	0.83
19	b0907	serC	phosphoserine aminotransferase (NCBI)	0.83	0.83
20	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.93	0.83

Or look for negative cofitness