Top cofit genes for b0331 from Escherichia coli BW25113

prpB: 2-methylisocitrate lyase (NCBI)
SEED: Methylisocitrate lyase (EC 4.1.3.30)
KEGG: methylisocitrate lyase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b3939	metB	cystathionine gamma-synthase (NCBI)	0.39	0.29
2	b2414	cysK	cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI)	0.27	0.28
3	b2026	hisI	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)	no	0.28
4	b2839	lysR	DNA-binding transcriptional dual regulator (NCBI)	0.36	0.27
5	b2750	cysC	adenylylsulfate kinase (NCBI)	no	0.27
6	b1262	trpC	N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS)	no	0.27
7	b0113	pdhR	transcriptional regulator of pyruvate dehydrogenase complex (NCBI)	0.48	0.26
8	b3368	cysG	fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI)	0.44	0.26
9	b3773	ilvY	DNA-binding transcriptional dual regulator (NCBI)	no	0.26
10	b4214	cysQ	PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI)	0.36	0.26
11	b2764	cysJ	sulfite reductase, alpha subunit, flavoprotein (NCBI)	no	0.26
12	b4018	iclR	repressor of aceBA operon (VIMSS)	no	0.26
13	b3008	metC	cystathionine beta-lyase (NCBI)	0.29	0.26
14	b1263	trpD	bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI)	0.41	0.26
15	b3429	glgA	glycogen synthase (NCBI)	0.52	0.26
16	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	no	0.26
17	b1264	trpE	anthranilate synthase component I (NCBI)	0.81	0.25
18	b3772	ilvA	threonine dehydratase (NCBI)	0.88	0.25
19	b2763	cysI	sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI)	no	0.25
20	b2479	gcvR	transcriptional regulation of gcv operon (VIMSS)	0.34	0.25

Or look for negative cofitness