Top cofit genes for b0331 from Escherichia coli BW25113

prpB: 2-methylisocitrate lyase (NCBI)
SEED: Methylisocitrate lyase (EC 4.1.3.30)
KEGG: methylisocitrate lyase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b3939	metB	cystathionine gamma-synthase (NCBI)	0.39	0.30
2	b2026	hisI	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)	no	0.29
3	b2414	cysK	cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI)	0.27	0.29
4	b1262	trpC	N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS)	no	0.28
5	b2839	lysR	DNA-binding transcriptional dual regulator (NCBI)	0.36	0.28
6	b2750	cysC	adenylylsulfate kinase (NCBI)	no	0.28
7	b3773	ilvY	DNA-binding transcriptional dual regulator (NCBI)	no	0.27
8	b3368	cysG	fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI)	0.44	0.27
9	b3008	metC	cystathionine beta-lyase (NCBI)	0.28	0.27
10	b2764	cysJ	sulfite reductase, alpha subunit, flavoprotein (NCBI)	no	0.27
11	b4214	cysQ	PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI)	0.36	0.27
12	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	no	0.27
13	b3772	ilvA	threonine dehydratase (NCBI)	0.88	0.27
14	b2763	cysI	sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI)	0.17	0.26
15	b0113	pdhR	transcriptional regulator of pyruvate dehydrogenase complex (NCBI)	0.57	0.26
16	b1264	trpE	anthranilate synthase component I (NCBI)	0.81	0.26
17	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	no	0.26
18	b1260	trpA	tryptophan synthase subunit alpha (NCBI)	0.83	0.26
19	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.19	0.26
20	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.82	0.26

Or look for negative cofitness