Top cofit genes for b0331 from Escherichia coli BW25113

prpB: 2-methylisocitrate lyase (NCBI)
SEED: Methylisocitrate lyase (EC 4.1.3.30)
KEGG: methylisocitrate lyase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b3939	metB	cystathionine gamma-synthase (NCBI)	0.39	0.33
2	b2026	hisI	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)	no	0.32
3	b2414	cysK	cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI)	no	0.32
4	b1262	trpC	N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS)	no	0.31
5	b2750	cysC	adenylylsulfate kinase (NCBI)	no	0.31
6	b2839	lysR	DNA-binding transcriptional dual regulator (NCBI)	0.36	0.31
7	b4214	cysQ	PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI)	0.36	0.30
8	b1264	trpE	anthranilate synthase component I (NCBI)	0.81	0.30
9	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	no	0.30
10	b3773	ilvY	DNA-binding transcriptional dual regulator (NCBI)	no	0.30
11	b3368	cysG	fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI)	0.42	0.30
12	b3008	metC	cystathionine beta-lyase (NCBI)	no	0.30
13	b2764	cysJ	sulfite reductase, alpha subunit, flavoprotein (NCBI)	no	0.29
14	b1260	trpA	tryptophan synthase subunit alpha (NCBI)	0.83	0.29
15	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.23	0.29
16	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.19	0.29
17	b1263	trpD	bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI)	0.41	0.29
18	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.82	0.29
19	b3772	ilvA	threonine dehydratase (NCBI)	0.88	0.29
20	b0073	leuB	3-isopropylmalate dehydrogenase (VIMSS)	0.51	0.29

Or look for negative cofitness