Top cofit genes for b0080 from Escherichia coli BW25113

fruR: DNA-binding transcriptional dual regulator (NCBI)
SEED: Fructose repressor FruR, LacI family
KEGG: LacI family transcriptional regulator, fructose operon transcriptional repressor

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b3236	mdh	malate dehydrogenase (NCBI)	0.98	0.67
2	b0723	sdhA	succinate dehydrogenase flavoprotein subunit (NCBI)	0.99	0.66
3	b0724	sdhB	succinate dehydrogenase, FeS subunit (NCBI)	0.98	0.66
4	b0721	sdhC	succinate dehydrogenase cytochrome b556 large membrane subunit (NCBI)	0.65	0.65
5	b4232	fbp	fructose-1,6-bisphosphatase (NCBI)	0.96	0.63
6	b0722	sdhD	succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI)	0.97	0.60
7	b3849	trkH	potassium transporter (NCBI)	0.67	0.60
8	b3601	mtlR	DNA-binding repressor (NCBI)	0.95	0.58
9	b2340	sixA	phosphohistidine phosphatase (NCBI)	0.62	0.58
10	b3169	nusA	transcription elongation factor NusA (NCBI)	0.63	0.54
11	b3385	gph	phosphoglycolate phosphatase (NCBI)	0.60	0.53
12	b2414	cysK	cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI)	no	0.53
13	b0726	sucA	alpha-ketoglutarate decarboxylase (NCBI)	0.75	0.52
14	b2422	cysA	sulfate/thiosulfate transporter subunit (NCBI)	0.86	0.50
15	b3204	ptsN	sugar-specific enzyme IIA component of PTS (NCBI)	0.68	0.50
16	b0676	nagC	DNA-binding transcriptional dual regulator, repressor of N-acetylglucosamine (NCBI)	0.96	0.49
17	b2278	nuoL	NADH dehydrogenase subunit L (NCBI)	0.98	0.48
18	b2276	nuoN	NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq)	0.96	0.48
19	b3939	metB	cystathionine gamma-synthase (NCBI)	0.48	0.48
20	b2277	nuoM	NADH dehydrogenase subunit M (NCBI)	0.97	0.48

Or look for negative cofitness