Top cofit genes for b0074 from Escherichia coli BW25113

leuA: 2-isopropylmalate synthase (NCBI)
SEED: 2-isopropylmalate synthase (EC 2.3.3.13)
KEGG: 2-isopropylmalate synthase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b0072	leuC	isopropylmalate isomerase large subunit (NCBI)	0.99	0.99
2	b0073	leuB	3-isopropylmalate dehydrogenase (VIMSS)	0.99	0.98
3	b0071	leuD	isopropylmalate isomerase small subunit (NCBI)	0.99	0.98
4	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.99	0.98
5	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.99	0.98
6	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.99	0.97
7	b3772	ilvA	threonine dehydratase (NCBI)	0.99	0.97
8	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.99	0.96
9	b2020	hisD	histidinol dehydrogenase (NCBI)	0.98	0.96
10	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.99	0.96
11	b2600	tyrA	fused chorismate mutase T/prephenate dehydrogenase (NCBI)	0.97	0.95
12	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	0.98	0.95
13	b2021	hisC	histidinol-phosphate aminotransferase (NCBI)	0.99	0.95
14	b0242	proB	gamma-glutamyl kinase (NCBI)	0.99	0.95
15	b2019	hisG	ATP phosphoribosyltransferase (NCBI)	0.99	0.95
16	b0243	proA	gamma-glutamyl phosphate reductase (NCBI)	0.98	0.94
17	b2026	hisI	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI)	0.97	0.94
18	b2599	pheA	fused chorismate mutase P/prephenate dehydratase (NCBI)	0.99	0.94
19	b2023	hisH	imidazole glycerol phosphate synthase subunit HisH (NCBI)	0.99	0.93
20	b3008	metC	cystathionine beta-lyase (NCBI)	0.97	0.93

Or look for negative cofitness