Top cofit genes for b0004 from Escherichia coli BW25113

thrC: threonine synthase (NCBI)
SEED: Threonine synthase (EC 4.2.3.1)
KEGG: threonine synthase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b0003	thrB	homoserine kinase (NCBI)	0.99	0.98
2	b0002	thrA	bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI)	0.99	0.96
3	b3960	argH	argininosuccinate lyase (NCBI)	0.99	0.95
4	b3172	argG	argininosuccinate synthase (NCBI)	0.99	0.94
5	b2838	lysA	diaminopimelate decarboxylase, PLP-binding (NCBI)	0.99	0.94
6	b0907	serC	phosphoserine aminotransferase (NCBI)	0.98	0.94
7	b4388	serB	3-phosphoserine phosphatase (NCBI)	0.91	0.93
8	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.99	0.93
9	b2913	serA	D-3-phosphoglycerate dehydrogenase (NCBI)	0.98	0.93
10	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.97	0.93
11	b2329	aroC	chorismate synthase (NCBI)	0.95	0.92
12	b3281	aroE	dehydroshikimate reductase, NAD(P)-binding (NCBI)	0.97	0.92
13	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.99	0.92
14	b3389	aroB	3-dehydroquinate synthase (NCBI)	0.91	0.92
15	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.99	0.92
16	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.98	0.91
17	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.98	0.91
18	b1260	trpA	tryptophan synthase subunit alpha (NCBI)	0.99	0.91
19	b1261	trpB	tryptophan synthase subunit beta (NCBI)	0.99	0.91
20	b2762	cysH	phosphoadenosine phosphosulfate reductase (NCBI)	0.95	0.91

Or look for negative cofitness