Top cofit genes for b0003 from Escherichia coli BW25113

thrB: homoserine kinase (NCBI)
SEED: Homoserine kinase (EC 2.7.1.39)
KEGG: homoserine kinase

Rank	Hit	Name	Description	Conserved?	Cofitness
1	b0004	thrC	threonine synthase (NCBI)	0.99	0.98
2	b0002	thrA	bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI)	0.98	0.96
3	b3960	argH	argininosuccinate lyase (NCBI)	0.99	0.96
4	b3172	argG	argininosuccinate synthase (NCBI)	0.99	0.95
5	b0907	serC	phosphoserine aminotransferase (NCBI)	0.97	0.94
6	b2838	lysA	diaminopimelate decarboxylase, PLP-binding (NCBI)	0.97	0.94
7	b2913	serA	D-3-phosphoglycerate dehydrogenase (NCBI)	0.95	0.93
8	b4388	serB	3-phosphoserine phosphatase (NCBI)	0.92	0.93
9	b3941	metF	5,10-methylenetetrahydrofolate reductase (NCBI)	0.97	0.93
10	b0908	aroA	3-phosphoshikimate 1-carboxyvinyltransferase (NCBI)	0.93	0.92
11	b2329	aroC	chorismate synthase (NCBI)	0.96	0.92
12	b3281	aroE	dehydroshikimate reductase, NAD(P)-binding (NCBI)	0.93	0.92
13	b3389	aroB	3-dehydroquinate synthase (NCBI)	0.91	0.91
14	b2762	cysH	phosphoadenosine phosphosulfate reductase (NCBI)	0.97	0.91
15	b3771	ilvD	dihydroxy-acid dehydratase (NCBI)	0.99	0.91
16	b3774	ilvC	ketol-acid reductoisomerase (NCBI)	0.99	0.91
17	b1260	trpA	tryptophan synthase subunit alpha (NCBI)	0.98	0.91
18	b3770	ilvE	branched-chain amino acid aminotransferase (NCBI)	0.97	0.91
19	b2025	hisF	imidazole glycerol phosphate synthase subunit HisF (NCBI)	0.98	0.91
20	b2022	hisB	imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS)	0.97	0.90

Or look for negative cofitness