Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1061

Experiment: 7H9 with Sisomicin 0.07 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1059 and Rv1060 are separated by 52 nucleotidesRv1060 and Rv1061 are separated by 33 nucleotidesRv1061 and Rv1062 are separated by 4 nucleotidesRv1062 and Rv1063c are separated by 0 nucleotides Rv1059: Rv1059 - Conserved protein, at 1,182,391 to 1,183,455 Rv1059 Rv1060: Rv1060 - Unknown protein, at 1,183,508 to 1,183,981 Rv1060 Rv1061: Rv1061 - Conserved protein, at 1,184,015 to 1,184,878 Rv1061 Rv1062: Rv1062 - Conserved hypothetical protein, at 1,184,883 to 1,185,740 Rv1062 Rv1063c: Rv1063c - Conserved hypothetical protein, at 1,185,741 to 1,186,823 Rv1063c Position (kb) 1184 1185Strain fitness (log2 ratio) -2 -1 0 1at 1183.088 kb on + strand, within Rv1059at 1184.139 kb on + strand, within Rv1061at 1184.166 kb on + strand, within Rv1061at 1184.291 kb on - strand, within Rv1061at 1184.291 kb on - strand, within Rv1061at 1184.424 kb on + strand, within Rv1061at 1184.522 kb on + strand, within Rv1061at 1184.522 kb on + strand, within Rv1061at 1184.559 kb on + strand, within Rv1061at 1184.560 kb on - strand, within Rv1061at 1184.560 kb on - strand, within Rv1061at 1184.594 kb on + strand, within Rv1061at 1184.595 kb on - strand, within Rv1061at 1184.597 kb on - strand, within Rv1061at 1184.597 kb on - strand, within Rv1061at 1184.597 kb on - strand, within Rv1061at 1185.082 kb on - strand, within Rv1062at 1185.448 kb on - strand, within Rv1062

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Sisomicin 0.07 mM
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1,183,088 + Rv1059 0.65 -0.5
1,184,139 + Rv1061 0.14 -0.7
1,184,166 + Rv1061 0.17 -0.4
1,184,291 - Rv1061 0.32 +0.7
1,184,291 - Rv1061 0.32 -1.4
1,184,424 + Rv1061 0.47 -0.1
1,184,522 + Rv1061 0.59 -1.5
1,184,522 + Rv1061 0.59 -0.1
1,184,559 + Rv1061 0.63 -1.3
1,184,560 - Rv1061 0.63 -0.2
1,184,560 - Rv1061 0.63 -0.9
1,184,594 + Rv1061 0.67 -0.6
1,184,595 - Rv1061 0.67 -0.5
1,184,597 - Rv1061 0.67 -1.2
1,184,597 - Rv1061 0.67 -1.8
1,184,597 - Rv1061 0.67 +1.7
1,185,082 - Rv1062 0.23 +0.3
1,185,448 - Rv1062 0.66 +1.0

Or see this region's nucleotide sequence