Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1880c

Experiment: 7H9 with methylglyoxal 1.2 mM

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1879 and Rv1880c are separated by 27 nucleotidesRv1880c and Rv1881c are separated by 49 nucleotidesRv1881c and Rv1882c are separated by 40 nucleotides Rv1879: Rv1879 - Conserved hypothetical protein, at 2,129,377 to 2,130,513 Rv1879 Rv1880c: Rv1880c - Probable cytochrome P450 140 Cyp140, at 2,130,541 to 2,131,857 Rv1880c Rv1881c: Rv1881c - Possible conserved lipoprotein LppE, at 2,131,907 to 2,132,329 Rv1881c Rv1882c: Rv1882c - Probable short-chain type dehydrogenase/reductase, at 2,132,370 to 2,133,203 Rv1882c Position (kb) 2130 2131 2132Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2129.621 kb on - strand, within Rv1879at 2129.621 kb on - strand, within Rv1879at 2130.121 kb on + strand, within Rv1879at 2130.121 kb on + strand, within Rv1879at 2130.203 kb on - strand, within Rv1879at 2130.230 kb on - strand, within Rv1879at 2130.230 kb on - strand, within Rv1879at 2130.325 kb on + strand, within Rv1879at 2130.326 kb on - strand, within Rv1879at 2130.464 kb on + strandat 2130.493 kb on + strandat 2130.512 kb on - strandat 2130.512 kb on - strandat 2130.824 kb on - strand, within Rv1880cat 2130.827 kb on + strand, within Rv1880cat 2130.828 kb on - strand, within Rv1880cat 2131.211 kb on - strand, within Rv1880cat 2131.232 kb on + strand, within Rv1880cat 2131.232 kb on + strand, within Rv1880cat 2131.259 kb on - strand, within Rv1880cat 2131.361 kb on + strand, within Rv1880cat 2131.361 kb on + strand, within Rv1880cat 2131.362 kb on - strand, within Rv1880cat 2131.362 kb on - strand, within Rv1880cat 2131.362 kb on - strand, within Rv1880cat 2131.370 kb on - strand, within Rv1880cat 2131.370 kb on - strand, within Rv1880cat 2131.676 kb on + strand, within Rv1880cat 2131.676 kb on + strand, within Rv1880cat 2131.724 kb on + strand, within Rv1880cat 2131.894 kb on + strandat 2131.894 kb on + strandat 2131.895 kb on - strandat 2131.895 kb on - strandat 2131.995 kb on + strand, within Rv1881cat 2131.995 kb on + strand, within Rv1881cat 2131.995 kb on + strand, within Rv1881cat 2131.995 kb on + strand, within Rv1881cat 2131.995 kb on + strand, within Rv1881cat 2131.996 kb on - strand, within Rv1881cat 2131.996 kb on - strand, within Rv1881cat 2131.996 kb on - strand, within Rv1881cat 2131.996 kb on - strand, within Rv1881cat 2132.117 kb on + strand, within Rv1881cat 2132.117 kb on + strand, within Rv1881cat 2132.118 kb on - strand, within Rv1881cat 2132.118 kb on - strand, within Rv1881cat 2132.371 kb on + strandat 2132.372 kb on - strandat 2132.479 kb on + strand, within Rv1882cat 2132.479 kb on + strand, within Rv1882cat 2132.479 kb on + strand, within Rv1882cat 2132.479 kb on + strand, within Rv1882cat 2132.479 kb on + strand, within Rv1882cat 2132.480 kb on - strand, within Rv1882cat 2132.506 kb on + strand, within Rv1882cat 2132.755 kb on + strand, within Rv1882cat 2132.766 kb on - strand, within Rv1882cat 2132.779 kb on + strand, within Rv1882cat 2132.779 kb on + strand, within Rv1882cat 2132.779 kb on + strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.780 kb on - strand, within Rv1882cat 2132.836 kb on + strand, within Rv1882cat 2132.836 kb on + strand, within Rv1882cat 2132.836 kb on + strand, within Rv1882cat 2132.837 kb on - strand, within Rv1882cat 2132.837 kb on - strand, within Rv1882cat 2132.851 kb on + strand, within Rv1882c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with methylglyoxal 1.2 mM
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2,129,621 - Rv1879 0.21 +1.8
2,129,621 - Rv1879 0.21 +1.6
2,130,121 + Rv1879 0.65 -0.4
2,130,121 + Rv1879 0.65 -0.5
2,130,203 - Rv1879 0.73 +0.1
2,130,230 - Rv1879 0.75 -0.2
2,130,230 - Rv1879 0.75 -0.2
2,130,325 + Rv1879 0.83 +0.7
2,130,326 - Rv1879 0.83 -0.3
2,130,464 + -0.4
2,130,493 + -0.1
2,130,512 - -0.8
2,130,512 - +0.8
2,130,824 - Rv1880c 0.21 -0.2
2,130,827 + Rv1880c 0.22 +0.2
2,130,828 - Rv1880c 0.22 -0.1
2,131,211 - Rv1880c 0.51 -0.3
2,131,232 + Rv1880c 0.52 -0.2
2,131,232 + Rv1880c 0.52 -1.4
2,131,259 - Rv1880c 0.55 -0.4
2,131,361 + Rv1880c 0.62 -0.4
2,131,361 + Rv1880c 0.62 -0.2
2,131,362 - Rv1880c 0.62 -0.8
2,131,362 - Rv1880c 0.62 +0.3
2,131,362 - Rv1880c 0.62 -0.2
2,131,370 - Rv1880c 0.63 +0.1
2,131,370 - Rv1880c 0.63 -0.2
2,131,676 + Rv1880c 0.86 -0.5
2,131,676 + Rv1880c 0.86 -0.7
2,131,724 + Rv1880c 0.90 -1.3
2,131,894 + +0.3
2,131,894 + -1.0
2,131,895 - -2.4
2,131,895 - -1.0
2,131,995 + Rv1881c 0.21 -0.5
2,131,995 + Rv1881c 0.21 -0.5
2,131,995 + Rv1881c 0.21 -0.4
2,131,995 + Rv1881c 0.21 +0.8
2,131,995 + Rv1881c 0.21 -0.5
2,131,996 - Rv1881c 0.21 -0.9
2,131,996 - Rv1881c 0.21 +1.8
2,131,996 - Rv1881c 0.21 +0.4
2,131,996 - Rv1881c 0.21 -0.4
2,132,117 + Rv1881c 0.50 +0.8
2,132,117 + Rv1881c 0.50 +0.0
2,132,118 - Rv1881c 0.50 +1.0
2,132,118 - Rv1881c 0.50 -3.2
2,132,371 + -1.3
2,132,372 - -0.5
2,132,479 + Rv1882c 0.13 +0.4
2,132,479 + Rv1882c 0.13 -2.1
2,132,479 + Rv1882c 0.13 -0.1
2,132,479 + Rv1882c 0.13 +0.8
2,132,479 + Rv1882c 0.13 -1.1
2,132,480 - Rv1882c 0.13 +0.4
2,132,506 + Rv1882c 0.16 -0.3
2,132,755 + Rv1882c 0.46 -1.1
2,132,766 - Rv1882c 0.47 +0.1
2,132,779 + Rv1882c 0.49 +0.2
2,132,779 + Rv1882c 0.49 -0.4
2,132,779 + Rv1882c 0.49 -0.8
2,132,780 - Rv1882c 0.49 -0.5
2,132,780 - Rv1882c 0.49 +1.2
2,132,780 - Rv1882c 0.49 -0.3
2,132,780 - Rv1882c 0.49 -1.1
2,132,780 - Rv1882c 0.49 -0.1
2,132,836 + Rv1882c 0.56 -0.1
2,132,836 + Rv1882c 0.56 -0.8
2,132,836 + Rv1882c 0.56 -0.5
2,132,837 - Rv1882c 0.56 -2.3
2,132,837 - Rv1882c 0.56 -0.6
2,132,851 + Rv1882c 0.58 -0.8

Or see this region's nucleotide sequence