Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2381c

Experiment: 7H9 with Ethambutol 0.75 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2380c and Rv2381c are separated by 139 nucleotidesRv2381c and Rv2382c overlap by 1 nucleotides Rv2380c: Rv2380c - Peptide synthetase MbtE (peptide synthase), at 2,662,067 to 2,667,115 Rv2380c Rv2381c: Rv2381c - Polyketide synthetase MbtD (polyketide synthase), at 2,667,255 to 2,670,269 Rv2381c Rv2382c: Rv2382c - Polyketide synthetase MbtC (polyketide synthase), at 2,670,269 to 2,671,603 Rv2382c Position (kb) 2667 2668 2669 2670 2671Strain fitness (log2 ratio) -2 -1 0 1at 2666.427 kb on + strand, within Rv2380cat 2667.254 kb on - strandat 2667.550 kb on + strandat 2667.705 kb on - strand, within Rv2381cat 2669.660 kb on + strand, within Rv2381cat 2671.123 kb on - strand, within Rv2382c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethambutol 0.75 ug/mL
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2,666,427 + Rv2380c 0.86 -2.0
2,667,254 - +0.1
2,667,550 + -0.7
2,667,705 - Rv2381c 0.15 -1.0
2,669,660 + Rv2381c 0.80 +0.9
2,671,123 - Rv2382c 0.64 +0.7

Or see this region's nucleotide sequence