SEED Subsystem: Methionine Biosynthesis in Klebsiella michiganensis M5al

Experiments:

Role Gene Name Sisomicin 0.008 mg/ml  
⨯
5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20) BWI76_RS00805 -0.3
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) BWI76_RS01685 -0.1
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) BWI76_RS01280 +0.1
  BWI76_RS15390 -0.1
Adenosylhomocysteinase (EC 3.3.1.1) BWI76_RS18745 -0.1
Archaeal S-adenosylmethionine synthetase (EC 2.5.1.6) No genes
Betaine--homocysteine S-methyltransferase (EC 2.1.1.5) No genes
Cystathionine beta-lyase (EC 4.4.1.8) BWI76_RS24285 +0.3
Cystathionine beta-lyase, type II (EC 4.4.1.8) No genes
Cystathionine beta-synthase (EC 4.2.1.22) BWI76_RS24205 -0.1
Cystathionine gamma-lyase (EC 4.4.1.1) BWI76_RS24210 +0.2
Cystathionine gamma-synthase (EC 2.5.1.48) BWI76_RS00785 +0.1
  BWI76_RS16730 -0.1
Cysteine synthase (EC 2.5.1.47) BWI76_RS20640 +1.2
Duplicated ATPase component MtsB of energizing module of methionine-regulated ECF transporter No genes
Homocysteine S-methyltransferase (EC 2.1.1.10) BWI76_RS06030 -0.4
Homoserine O-acetyltransferase (EC 2.3.1.31) No genes
Homoserine O-succinyltransferase (EC 2.3.1.46) BWI76_RS01655 +0.1
Homoserine dehydrogenase (EC 1.1.1.3) BWI76_RS00790 -0.1
  BWI76_RS04245 +0.2
Homoserine kinase (EC 2.7.1.39) BWI76_RS04250 +0.3
Methionine ABC transporter ATP-binding protein BWI76_RS05365 -1.0
  BWI76_RS15030 +0.6
  BWI76_RS16675 -1.1
Methionine ABC transporter permease protein BWI76_RS05360 -0.6
  BWI76_RS15035 -0.6
  BWI76_RS16665 -0.0
Methionine ABC transporter substrate-binding protein BWI76_RS05355 -2.2
  BWI76_RS15025 N.D.
  BWI76_RS16320 -0.1
  BWI76_RS16670 -0.0
  BWI76_RS17105 -0.3
  BWI76_RS27655 +0.2
Methionine repressor MetJ BWI76_RS00780 N.D.
Methionine synthase activation domain (EC 2.1.1.13) No genes
Methionine transporter MetT No genes
O-acetylhomoserine sulfhydrylase (EC 2.5.1.49) No genes
O-succinylhomoserine sulfhydrylase (EC 2.5.1.48) No genes
Predicted regulator of methionine metabolism, ArsR family No genes
S-adenosylhomocysteine nucleosidase (EC 3.2.2.9) BWI76_RS05170 N.D.
S-adenosylmethionine synthetase (EC 2.5.1.6) BWI76_RS24050 N.D.
S-ribosylhomocysteine lyase (EC 4.4.1.21) BWI76_RS22115 -0.1
SAM-dependent methlytransferase UbiG No genes
SAM-dependent methlytransferase YrrT No genes
Serine acetyltransferase (EC 2.3.1.30) BWI76_RS05560 N.D.
  BWI76_RS27205 N.D.
Substrate-specific component MtsA of methionine-regulated ECF transporter No genes
Transcriptional activator MetR BWI76_RS01275 +0.3
Transmembrane component MtsC of energizing module of methionine-regulated ECF transporter No genes

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