MetaCyc Pathway: superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation in Pseudomonas fluorescens FW300-N2E2

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Reactions and Genes L-Lysine (N)
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Arginine decarboxylase:
L-arginine + H+→agmatine + CO2 (EC 4.1.1.19)
Pf6N2E2_3334 +0.2
Pf6N2E2_3504 -0.1
Agmatinase:
agmatine + H2O→putrescine + urea (EC 3.5.3.11)
Pf6N2E2_2655 -0.4
Putrescine aminotransferase:
putrescine + 2-oxoglutarate→4-aminobutanal + L-glutamate (EC 2.6.1.82)
No genes
Glutamate--putrescine ligase:
putrescine + ATP + L-glutamate→γ-glutamyl-L-putrescine + ADP + H+ + phosphate (EC 6.3.1.11)
Pf6N2E2_4509 +0.0
Aminobutyraldehyde dehydrogenase:
4-aminobutanal + NAD+ + H2O→4-aminobutanoate + NADH + 2 H+ (EC 1.2.1.19)
Pf6N2E2_1381 -1.2
Pf6N2E2_1764 +0.0
Pf6N2E2_1854 +0.0
Pf6N2E2_1874 N.D.
Pf6N2E2_1878 -0.0
Pf6N2E2_1906 +0.0
Pf6N2E2_1919 -0.0
Pf6N2E2_261 -0.2
Pf6N2E2_3126 +0.1
Pf6N2E2_3131 -0.2
Pf6N2E2_351 +0.2
Pf6N2E2_4383 +0.0
Pf6N2E2_4964 -0.2
Pf6N2E2_4979 -0.0
Pf6N2E2_5476 -0.0
Pf6N2E2_935 +0.1
γ-glutamyl-L-putrescine + dioxygen + H2O→4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide (EC 1.4.3.M3)
Pf6N2E2_4388 -0.2
Pf6N2E2_80 +0.1
4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O→4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ (EC 1.2.1.99)
Pf6N2E2_4383 +0.0
Gamma-glutamyl-gamma-aminobutyrate hydrolase:
4-(γ-L-glutamylamino)butanoate + H2O→4-aminobutanoate + L-glutamate (EC 3.5.1.94)
Pf6N2E2_4510 +0.4
4-aminobutyrate transaminase:
4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19)
Pf6N2E2_373 +0.2
Pf6N2E2_3877 +0.0
Pf6N2E2_4013 -2.2
Pf6N2E2_4512 -0.4
Pf6N2E2_5269 -0.0
Succinate-semialdehyde dehydrogenase:
succinate semialdehyde + NAD+ + H2O→succinate + NADH + 2 H+ (EC 1.2.1.24)
No genes
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
Pf6N2E2_368 +0.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information