MetaCyc Pathway: adipate degradation in Klebsiella michiganensis M5al

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Reactions and Genes rhizosphere EcoFAB sample 3; outgrowth in LB
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Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)
BWI76_RS08425 -4.0
BWI76_RS08430 -5.3
BWI76_RS16140 -1.2
adipoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
BWI76_RS02590 -1.4
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
BWI76_RS01365 -1.9
BWI76_RS01370 N.D.
BWI76_RS13115 N.D.
BWI76_RS13120 N.D.
BWI76_RS20455 -0.6
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
BWI76_RS01365 -1.9
BWI76_RS01370 N.D.
BWI76_RS13125 +0.2
BWI76_RS20455 -0.6
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
BWI76_RS13135 -0.3
BWI76_RS16135 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information