Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0675 and Rv0676c are separated by 11 nucleotidesRv0676c and Rv0677c overlap by 4 nucleotidesRv0677c and Rv0678 are separated by 84 nucleotidesRv0678 and Rv0679c are separated by 55 nucleotides Rv0675: Rv0675 - Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 774,783 to 775,574 Rv0675 Rv0676c: Rv0676c - Probable conserved transmembrane transport protein MmpL5, at 775,586 to 778,480 Rv0676c Rv0677c: Rv0677c - Possible conserved membrane protein MmpS5, at 778,477 to 778,905 Rv0677c Rv0678: Rv0678 - Conserved protein, at 778,990 to 779,487 Rv0678 Rv0679c: Rv0679c - Conserved threonine rich protein, at 779,543 to 780,040 Rv0679c
Group Condition Rv0675 Rv0676c Rv0677c Rv0678 Rv0679c
stress 7H9 with Clofazimine 0.072 ug/mL -2.1 -2.9 -1.3 +1.3 -0.2
stress 7H9 with Bedaquiline 0.15 ug/mL -2.7 -3.7 +0.2 +1.1 -0.1
stress 7H9 with Bedaquiline 0.15 ug/mL -0.8 -3.7 -1.1 +1.2 -0.7
stress 7H9 with Levofloxacin 0.3 ug/mL -3.9 -0.1 -0.6 +0.0 -0.2
nitrogen source L-Alanine 10 mM (N) -1.3 -2.0 -1.8 +0.2 +0.2
stress 7H9 with Dodecyl Sulfate 0.02 vol% -3.7 -0.5 +0.3 -0.5 -0.2
stress 7H9 with Irgasan 0.065 mM -3.7 -0.5 -0.3 +0.2 -0.1
nitrogen source L-Aspartic Acid 10 mM (N) -1.4 -1.7 -1.1 +0.2 -0.3
carbon source L-Aspartic Acid (C) -2.1 -0.9 -0.3 -0.4 -0.3
stress 7H9 with Levofloxacin 0.3 ug/mL -3.9 -0.2 +0.1 +0.3 -0.3
stress 7H9 with Nickel (II) chloride 0.6 mM -2.3 -0.6 -0.6 +0.0 -0.5
nitrogen source L-Alanine 10 mM (N) -0.4 -1.6 -2.0 -0.0 +0.2
nitrogen source L-Glutamic 10 mM (N) -1.7 -1.2 -1.4 +0.2 +0.3
nitrogen source L-Serine 10 mM (N) +0.2 -2.6 -1.6 +0.4 -0.1
nitrogen source L-Asparagine 10 mM (N) -0.8 -2.2 -1.3 +0.7 +0.0
stress 7H9 with Clofazimine 0.072 ug/mL -0.3 -3.0 -1.2 +1.3 -0.3
stress 7H9 with Erythromycin 0.016 mM -1.0 -1.1 -1.0 +0.4 -0.9
nitrogen source L-Serine 10 mM (N) +0.2 -2.6 -1.3 +0.1 +0.2
stress 7H9 with Clofazimine 0.45 ug/mL -0.4 -2.9 -1.6 +2.1 -0.6
stress 7H9 with Clofazimine 0.45 ug/mL -2.1 -3.0 -0.8 +2.1 +0.4
carbon source Glycerol (C) -1.7 -1.0 -0.6 +0.4 -0.5
no stress control no stress control -3.7 -0.2 +0.8 -0.3 +0.1
nitrogen source L-Asparagine 10 mM (N) -0.8 -1.5 -1.2 +0.6 -0.2
stress 7H9 with Linezolid 0.3 ug/mL -3.8 -0.2 +0.7 +0.3 -0.1
nitrogen source L-Glutamic 10 mM (N) -1.1 -1.2 -1.2 +0.1 +0.4
no stress control no stress control -3.4 -0.0 +0.4 -0.1 +0.3
nitrogen source Urea 10mM (N) -1.5 -0.8 -1.1 +0.7 +0.3
nitrogen source Glycine 10 mM (N) +0.6 -1.9 -1.4 +0.4 +0.2
stress 7H9 with Econazole nitrate salt 0.0082 mM +0.2 -1.9 -1.8 +2.4 -0.1
stress 7H9 with Econazole nitrate salt 0.0082 mM -0.3 -1.7 -1.2 +2.0 +0.2
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