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Fitness for 5 genes in
Mycobacterium tuberculosis H37Rv
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Top 30 experiments (either direction), sorted by average fitness
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500 nt
Rv0374c and Rv0375c are separated by 14 nucleotides
Rv0375c and Rv0376c are separated by 75 nucleotides
Rv0376c and Rv0377 are separated by 48 nucleotides
Rv0377 and Rv0378 are separated by 250 nucleotides
Rv0374c: Rv0374c - Probable carbon monoxyde dehydrogenase (small chain), at 451,800 to 452,279
Rv0374c
Rv0375c: Rv0375c - Probable carbon monoxyde dehydrogenase (medium chain), at 452,294 to 453,154
Rv0375c
Rv0376c: Rv0376c - Conserved hypothetical protein, at 453,230 to 454,372
Rv0376c
Rv0377: Rv0377 - Probable transcriptional regulatory protein (probably LysR-family), at 454,421 to 455,386
Rv0377
Rv0378: Rv0378 - Conserved hypothetical glycine rich protein, at 455,637 to 455,858
Rv0378
Group
Condition
Rv0374c
Rv0375c
Rv0376c
Rv0377
Rv0378
stress
7H9 with Levofloxacin 0.3 ug/mL
+0.2
-2.8
-0.4
+0.3
-0.7
nitrogen source
L-Valine 10 mM (N)
-0.3
-1.9
-0.2
+0.2
-0.2
pH
pH 4.5
-0.1
-0.9
-0.1
-0.1
-1.0
stress
7H9 with Irgasan 0.065 mM
-1.3
+0.0
-0.3
-0.1
-0.5
carbon source
Palmitic 100 uM (C)
-0.5
-1.0
-0.7
+0.0
+0.0
stress
7H9 with nitrite 3 mM; pH 5.5
-0.5
-0.7
-0.6
-0.2
-0.1
stress
7H9 with Ramoplanin 0.009 mM
-0.3
-0.9
+0.0
+0.1
-1.1
stress
7H9 with Rifampicin 0.014 ug/mL
-0.8
-0.4
+0.1
-0.7
-0.2
stress
7H9 with Hydrogen peroxide 2.5 mM; pH 6.5
+0.3
-0.5
-0.6
+0.3
-1.5
stress
7H9 with Sisomicin 0.07 mM
-0.1
+0.5
-0.8
-1.0
-0.6
stress
7H9 with Moxifloxacin 0.121 ug/mL
-0.1
-1.5
-0.3
+0.0
+0.0
stress
7H9 with Linezolid 0.44 ug/mL
-0.6
-1.0
+0.3
-0.4
+0.1
stress
7H9 with Phenazine ethosulfate 0.0137 mM
+0.1
-0.7
+0.3
-0.3
-0.7
stress
7H9 with nitrate 4 mM
+0.6
-1.1
-0.2
-0.0
-0.5
no stress control
no stress control
+0.4
-0.6
-0.2
-0.0
-0.7
stress
7H9 with Formaldehyde 0.23 mM
-0.3
-0.2
+0.4
-0.8
-0.2
stress
7H9 with Ethionamide 0.1 ug/mL
-0.5
-0.8
+0.5
-0.0
-0.2
pH
7H9 pH 5.5
+0.2
-0.8
-0.5
-0.1
+0.3
stress
7H9 with copper (II) chloride 0.08 mM
+0.1
+0.7
-0.3
-0.7
-0.6
no stress control
no stress control
+0.2
+0.5
+0.0
-0.7
-0.7
stress
7H9 with Nickel (II) chloride 0.6 mM
-1.0
-0.4
+0.1
+0.2
+0.3
nitrogen source
L-Aspartic Acid 10 mM (N)
+0.1
-0.5
-0.9
+0.4
+0.2
nitrogen source
L-Asparagine 10 mM (N)
+0.3
-0.6
-0.5
+0.4
-0.2
no stress control
no stress control
+0.8
-1.1
+0.2
-0.1
+0.2
stress
7H9 with Dibucaine 0.21 mM
+0.2
-1.4
+0.6
-0.0
+0.7
stress
7H9 with Lomefloxacin 0.0035 mM
-0.7
+0.7
+0.5
-0.2
-0.0
stress
7H9 with Cetrimonium bromide 0.015 vol%
-0.3
+0.6
+0.7
-0.1
-0.4
nitrogen source
Ammonium chloride 10mM (N)
+0.3
+0.3
-0.5
+0.6
-0.3
stress
7H9 with Phenazine methosulfate 0.0054 mM
+0.6
-0.9
+0.7
+0.5
+0.1
stress
7H9 with Isoniazid 0.025 ug/mL
+0.3
+0.8
+0.2
+0.3
-0.2
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