Fitness for 5 genes in Mycobacterium tuberculosis H37Rv

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500 ntRv0374c and Rv0375c are separated by 14 nucleotidesRv0375c and Rv0376c are separated by 75 nucleotidesRv0376c and Rv0377 are separated by 48 nucleotidesRv0377 and Rv0378 are separated by 250 nucleotides Rv0374c: Rv0374c - Probable carbon monoxyde dehydrogenase (small chain), at 451,800 to 452,279 Rv0374c Rv0375c: Rv0375c - Probable carbon monoxyde dehydrogenase (medium chain), at 452,294 to 453,154 Rv0375c Rv0376c: Rv0376c - Conserved hypothetical protein, at 453,230 to 454,372 Rv0376c Rv0377: Rv0377 - Probable transcriptional regulatory protein (probably LysR-family), at 454,421 to 455,386 Rv0377 Rv0378: Rv0378 - Conserved hypothetical glycine rich protein, at 455,637 to 455,858 Rv0378
Group Condition Rv0374c Rv0375c Rv0376c Rv0377 Rv0378
stress 7H9 with Levofloxacin 0.3 ug/mL +0.2 -2.8 -0.4 +0.3 -0.7
nitrogen source L-Valine 10 mM (N) -0.3 -1.9 -0.2 +0.2 -0.2
pH pH 4.5 -0.1 -0.9 -0.1 -0.1 -1.0
stress 7H9 with Irgasan 0.065 mM -1.3 +0.0 -0.3 -0.1 -0.5
carbon source Palmitic 100 uM (C) -0.5 -1.0 -0.7 +0.0 +0.0
stress 7H9 with nitrite 3 mM; pH 5.5 -0.5 -0.7 -0.6 -0.2 -0.1
stress 7H9 with Ramoplanin 0.009 mM -0.3 -0.9 +0.0 +0.1 -1.1
stress 7H9 with Rifampicin 0.014 ug/mL -0.8 -0.4 +0.1 -0.7 -0.2
stress 7H9 with Hydrogen peroxide 2.5 mM; pH 6.5 +0.3 -0.5 -0.6 +0.3 -1.5
stress 7H9 with Sisomicin 0.07 mM -0.1 +0.5 -0.8 -1.0 -0.6
stress 7H9 with Moxifloxacin 0.121 ug/mL -0.1 -1.5 -0.3 +0.0 +0.0
stress 7H9 with Linezolid 0.44 ug/mL -0.6 -1.0 +0.3 -0.4 +0.1
stress 7H9 with Phenazine ethosulfate 0.0137 mM +0.1 -0.7 +0.3 -0.3 -0.7
stress 7H9 with nitrate 4 mM +0.6 -1.1 -0.2 -0.0 -0.5
no stress control no stress control +0.4 -0.6 -0.2 -0.0 -0.7
stress 7H9 with Formaldehyde 0.23 mM -0.3 -0.2 +0.4 -0.8 -0.2
stress 7H9 with Ethionamide 0.1 ug/mL -0.5 -0.8 +0.5 -0.0 -0.2
pH 7H9 pH 5.5 +0.2 -0.8 -0.5 -0.1 +0.3
stress 7H9 with copper (II) chloride 0.08 mM +0.1 +0.7 -0.3 -0.7 -0.6
no stress control no stress control +0.2 +0.5 +0.0 -0.7 -0.7
stress 7H9 with Nickel (II) chloride 0.6 mM -1.0 -0.4 +0.1 +0.2 +0.3
nitrogen source L-Aspartic Acid 10 mM (N) +0.1 -0.5 -0.9 +0.4 +0.2
nitrogen source L-Asparagine 10 mM (N) +0.3 -0.6 -0.5 +0.4 -0.2
no stress control no stress control +0.8 -1.1 +0.2 -0.1 +0.2
stress 7H9 with Dibucaine 0.21 mM +0.2 -1.4 +0.6 -0.0 +0.7
stress 7H9 with Lomefloxacin 0.0035 mM -0.7 +0.7 +0.5 -0.2 -0.0
stress 7H9 with Cetrimonium bromide 0.015 vol% -0.3 +0.6 +0.7 -0.1 -0.4
nitrogen source Ammonium chloride 10mM (N) +0.3 +0.3 -0.5 +0.6 -0.3
stress 7H9 with Phenazine methosulfate 0.0054 mM +0.6 -0.9 +0.7 +0.5 +0.1
stress 7H9 with Isoniazid 0.025 ug/mL +0.3 +0.8 +0.2 +0.3 -0.2
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