Experiment set9IT093 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Tetracycline hydrochloride 0.0000003125 mM

200 most important genes:

  gene name fitness t score description  
b1334 fnr -4.2 -2.9 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b4238 nrdD -3.4 -18.6 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b4237 nrdG -3.3 -12.2 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b3465 yhhF -2.7 -7.6 predicted methyltransferase (NCBI) compare
b0053 surA -2.6 -4.5 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0462 acrB -2.3 -15.2 multidrug efflux system protein (NCBI) compare
b0737 tolQ -2.2 -2.9 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0677 nagA -2.2 -6.3 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b3021 ygiT -2.1 -2.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b0014 dnaK -2.1 -2.3 molecular chaperone DnaK (NCBI) compare
b4402 yjjY -2.1 -1.4 hypothetical protein (NCBI) compare
b0902 pflA -2.0 -7.9 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0437 clpP -2.0 -6.0 ATP-dependent Clp protease proteolytic subunit (NCBI) compare
b1818 manY -2.0 -3.1 mannose-specific enzyme IIC component of PTS (NCBI) compare
b4025 pgi -2.0 -8.2 glucose-6-phosphate isomerase (NCBI) compare
b0463 acrA -1.9 -10.2 multidrug efflux system (NCBI) compare
b3229 sspA -1.8 -2.4 stringent starvation protein A (NCBI) compare
b4515 ybgT -1.8 -2.5 hypothetical protein (NCBI) compare
b3035 tolC -1.8 -7.5 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0738 tolR -1.8 -1.2 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b1286 rnb -1.7 -1.9 exoribonuclease II (NCBI) compare
b1882 cheY -1.7 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b0739 tolA -1.6 -2.3 cell envelope integrity inner membrane protein TolA (NCBI) compare
b0730 mngR -1.6 -1.0 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b0438 clpX -1.5 -5.8 ATP-dependent protease ATP-binding subunit (NCBI) compare
b3163 nlpI -1.5 -4.4 hypothetical protein (NCBI) compare
b1438 ydcQ -1.4 -3.8 predicted DNA-binding transcriptional regulator (RefSeq) compare
b2620 smpB -1.4 -1.3 SsrA-binding protein (NCBI) compare
b1171 b1171 -1.4 -1.9 orf, hypothetical protein (VIMSS) compare
b0239 frsA -1.4 -7.5 fermentation/respiration switch protein (NCBI) compare
b0741 pal -1.4 -3.2 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0145 dksA -1.4 -2.6 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0763 modA -1.4 -4.9 molybdate transporter subunit (NCBI) compare
b3857 mobA -1.4 -5.6 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b0740 tolB -1.4 -3.4 translocation protein TolB precursor (NCBI) compare
b1109 ndh -1.4 -3.5 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b3930 menA -1.3 -10.2 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3839 tatC -1.3 -5.5 TatABCE protein translocation system subunit (NCBI) compare
b4535 yniD -1.3 -1.7 predicted protein (RefSeq) compare
b0783 moaC -1.3 -5.0 molybdenum cofactor biosynthesis protein C (NCBI) compare
b2376 ypdI -1.3 -2.3 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b2727 hypB -1.2 -4.2 GTP hydrolase involved in nickel liganding into hydrogenases (NCBI) compare
b1361 ydaW -1.2 -0.6 orf, hypothetical protein (VIMSS) compare
b0683 fur -1.2 -1.3 ferric uptake regulator (NCBI) compare
b3082 ygjM -1.2 -1.5 predicted DNA-binding transcriptional regulator (NCBI) compare
b1677 lpp -1.2 -2.2 murein lipoprotein (NCBI) compare
b1506 yneL -1.2 -1.0 predicted transcriptional regulator (NCBI) compare
b1961 dcm -1.2 -1.2 DNA cytosine methylase (NCBI) compare
b1758 b1758 -1.2 -1.5 putative cytochrome oxidase (VIMSS) compare
b4603 rseX -1.2 -0.6 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b0765 modC -1.1 -4.6 molybdate transporter subunit (NCBI) compare
b2814 metZ -1.1 -1.5 tRNA-Met (NCBI) compare
b4701 sokX -1.1 -0.7 sok-related sRNA, function unknown (RefSeq) compare
b4589 ylcI -1.1 -2.1 hypothetical protein (RefSeq) compare
b1192 ldcA -1.1 -4.0 L,D-carboxypeptidase A (NCBI) compare
b1434 ydcN -1.1 -2.1 predicted DNA-binding transcriptional regulator (NCBI) compare
b1686 ydiI -1.1 -2.0 hypothetical protein (NCBI) compare
b0296 ykgM -1.1 -3.1 50S ribosomal protein L31 (NCBI) compare
b4201 priB -1.1 -2.2 primosomal replication protein N (NCBI) compare
b0990 cspG -1.1 -0.7 DNA-binding transcriptional regulator (NCBI) compare
b0903 pflB -1.1 -7.0 pyruvate formate lyase I (NCBI) compare
b2937 speB -1.1 -4.5 agmatinase (NCBI) compare
b4042 dgkA -1.0 -1.7 diacylglycerol kinase (NCBI) compare
b4414 tff -1.0 -2.2 unknown RNA (NCBI) compare
b2456 cchB -1.0 -2.3 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b4570 lomR -1.0 -1.7 no description compare
b2363 yfdT -1.0 -1.5 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b2188 yejM -1.0 -6.0 predicted hydrolase, inner membrane (NCBI) compare
b1533 ydeD -1.0 -2.2 orf, hypothetical protein (VIMSS) compare
b2215 ompC -1.0 -5.6 outer membrane porin protein C (NCBI) compare
b2953 yggU -1.0 -0.9 orf, hypothetical protein (VIMSS) compare
b1413 hrpA -1.0 -5.9 ATP-dependent helicase (RefSeq) conserved
b1259 yciG -1.0 -1.4 orf, hypothetical protein (VIMSS) compare
b0009 mog -1.0 -4.4 molybdenum cofactor biosynthesis protein (NCBI) compare
b1765 ydjA -1.0 -1.1 predicted oxidoreductase (NCBI) compare
b0957 ompA -1.0 -2.7 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b2510 b2510 -1.0 -3.5 orf, hypothetical protein (VIMSS) compare
b3838 tatB -1.0 -4.7 sec-independent translocase (NCBI) compare
b1600 mdtJ -1.0 -0.9 multidrug efflux system transporter (NCBI) compare
b3636 rpmG -1.0 -0.8 50S ribosomal protein L33 (NCBI) compare
b1792 yeaO -1.0 -2.6 orf, hypothetical protein (VIMSS) compare
b1607 ydgC -1.0 -1.3 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1346 ydaQ -1.0 -1.3 orf, hypothetical protein (VIMSS) compare
b2528 iscA -0.9 -1.3 iron-sulfur cluster assembly protein (NCBI) compare
b4435 isrC -0.9 -1.9 unknown RNA (NCBI) compare
b1566 flxA -0.9 -2.1 Qin prophage; predicted protein (NCBI) compare
b2329 aroC -0.9 -3.3 chorismate synthase (NCBI) compare
b2518 ndk -0.9 -1.7 nucleoside diphosphate kinase (NCBI) compare
b4695 ykgT -0.9 -1.7 no description compare
b2288 nuoA -0.9 -2.4 NADH dehydrogenase I chain A (VIMSS) compare
b3493 pitA -0.9 -3.8 phosphate transporter, low-affinity (NCBI) compare
b0866 ybjQ -0.9 -1.2 hypothetical protein (NCBI) compare
b1836 yebV -0.9 -1.6 orf, hypothetical protein (VIMSS) compare
b3478 nikC -0.9 -5.5 nickel transporter subunit (NCBI) compare
b4458 oxyS -0.9 -1.0 global regulatory RNA (NCBI) compare
b0781 moaA -0.9 -5.2 molybdenum cofactor biosynthesis protein A (NCBI) compare
b1348 lar -0.9 -1.1 Rac prophage; restriction alleviation protein (NCBI) compare
b0623 cspE -0.9 -1.6 cold shock protein E (NCBI) compare
b0819 ybiS -0.9 -5.0 hypothetical protein (NCBI) compare
b4545 ypdJ -0.9 -1.5 no description compare
b2282 nuoH -0.9 -2.3 NADH dehydrogenase subunit H (NCBI) compare
b0827 moeA -0.9 -3.0 molybdopterin biosynthesis protein (NCBI) compare
b0764 modB -0.9 -3.2 molybdate ABC transporter permease protein (NCBI) compare
b2569 lepA -0.9 -2.5 GTP-binding protein LepA (NCBI) compare
b1161 ycgX -0.9 -0.7 hypothetical protein (NCBI) compare
b2997 hybO -0.9 -4.4 hydrogenase 2, small subunit (NCBI) compare
b0548 ninE -0.9 -2.8 DLP12 prophage; conserved protein (NCBI) compare
b2939 yqgB -0.9 -1.2 predicted protein (RefSeq) compare
b0232 yafN -0.8 -0.5 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b3237 argR -0.8 -2.4 arginine repressor (NCBI) compare
b0785 moaE -0.8 -2.5 molybdopterin synthase, large subunit (NCBI) compare
b4550 yhdL -0.8 -3.8 hypothetical protein (NCBI) compare
b0406 tgt -0.8 -3.9 queuine tRNA-ribosyltransferase (NCBI) compare
b3784 rfe -0.8 -6.2 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase (NCBI) compare
b3764 yifE -0.8 -2.5 hypothetical protein (NCBI) compare
b1025 ycdT -0.8 -0.7 predicted diguanylate cyclase (NCBI) compare
b1874 cutC -0.8 -1.6 copper homeostasis protein (NCBI) compare
b3836 b3836 -0.8 -2.3 orf, hypothetical protein (VIMSS) compare
b1855 lpxM -0.8 -2.9 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (NCBI) compare
b0471 ybaB -0.8 -2.4 hypothetical protein (NCBI) compare
b0049 apaH -0.8 -1.8 diadenosinetetraphosphatase (NCBI) compare
b4179 vacB -0.8 -3.0 putative enzyme (VIMSS) compare
b4529 ydbJ -0.8 -1.0 hypothetical protein (NCBI) compare
b1827 kdgR -0.8 -2.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b0908 aroA -0.8 -4.2 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b1590 ynfH -0.8 -2.7 oxidoreductase, membrane subunit (NCBI) compare
b3476 nikA -0.8 -4.5 nickel transporter subunit (NCBI) compare
b0826 moeB -0.8 -3.4 molybdopterin biosynthesis protein MoeB (NCBI) compare
b2143 cdd -0.8 -2.6 cytidine deaminase (NCBI) compare
b3649 rpoZ -0.8 -1.8 DNA-directed RNA polymerase subunit omega (NCBI) compare
b1168 b1168 -0.8 -1.2 putative proteases (VIMSS) compare
b3870 glnA -0.8 -1.5 glutamine synthetase (NCBI) compare
b4509 ylcG -0.8 -1.7 DLP12 prophage; predicted protein (NCBI) compare
b4579 yaiX -0.8 -2.8 no description compare
b2479 gcvR -0.7 -2.8 transcriptional regulation of gcv operon (VIMSS) compare
b1620 malI -0.7 -1.5 DNA-binding transcriptional repressor (NCBI) compare
b0736 ybgC -0.7 -2.1 predicted acyl-CoA thioesterase (NCBI) compare
b1951 rcsA -0.7 -0.5 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b1921 fliZ -0.7 -1.9 orf, hypothetical protein (VIMSS) compare
b3094 exuR -0.7 -3.1 negative regulator of exu regulon, exuT, uxaAC, and uxuB (VIMSS) compare
b2553 glnB -0.7 -2.4 regulatory protein P-II for glutamine synthetase (NCBI) compare
b1830 prc -0.7 -2.5 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b1431 ydcL -0.7 -2.1 predicted lipoprotein (NCBI) compare
b3479 nikD -0.7 -3.9 nickel transporter subunit (NCBI) compare
b0550 rusA -0.7 -1.1 DLP12 prophage; endonuclease RUS (NCBI) compare
b0802 ybiJ -0.7 -1.7 hypothetical protein (NCBI) compare
b3446 yrhB -0.7 -2.5 hypothetical protein (NCBI) compare
b3226 yhcK -0.7 -2.6 putative FADA-type transcriptional regulator (VIMSS) compare
b0688 pgm -0.7 -1.8 phosphoglucomutase (NCBI) compare
b1485 ddpC -0.7 -2.1 D-ala-D-ala transporter subunit (NCBI) compare
b0965 b0965 -0.7 -1.4 orf, hypothetical protein (VIMSS) compare
b1861 ruvA -0.7 -0.4 Holliday junction DNA helicase motor protein (NCBI) compare
b4240 treB -0.7 -4.8 fused trehalose(maltose)-specific PTS enzyme: IIB component/IIC component (NCBI) compare
b2698 recX -0.7 -1.7 RecA regulator RecX (NCBI) compare
b1591 b1591 -0.7 -1.3 putative oxidoreductase component (VIMSS) compare
b0746 valZ -0.7 -1.5 tRNA-Val (NCBI) compare
b2423 cysW -0.7 -2.9 sulfate/thiosulfate transporter subunit (NCBI) compare
b3164 pnp -0.7 -1.4 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b1295 ymjA -0.7 -1.6 hypothetical protein (NCBI) compare
b4494 arpB -0.7 -0.4 no description compare
b2712 hypF -0.7 -4.4 carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases (NCBI) compare
b2995 hybB -0.7 -4.3 predicted hydrogenase 2 cytochrome b type component (NCBI) compare
b3644 yicC -0.7 -3.2 hypothetical protein (NCBI) compare
b1536 ydeI -0.7 -0.4 hypothetical protein (NCBI) compare
b1095 fabF -0.7 -3.2 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2729 hypD -0.7 -3.8 protein required for maturation of hydrogenases (NCBI) compare
b2174 b2174 -0.7 -3.8 orf, hypothetical protein (VIMSS) compare
b0563 tfaX -0.7 -2.7 DLP12 prophage; predicted protein (RefSeq) compare
b1503 ydeR -0.7 -1.5 predicted fimbrial-like adhesin protein (NCBI) compare
b1124 potC -0.7 -2.4 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b0506 allR -0.7 -2.9 DNA-binding transcriptional repressor (NCBI) compare
b3349 slyD -0.7 -3.3 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b1123 potD -0.6 -2.6 spermidine/putrescine ABC transporter periplasmic substrate-binding protein (NCBI) compare
b1040 csgD -0.6 -0.4 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b4480 hdfR -0.6 -2.5 transcriptional regulator HdfR (NCBI) compare
b2962 yggX -0.6 -1.6 hypothetical protein (NCBI) compare
b1579 intQ -0.6 -1.1 Qin prophage; predicted defective integrase (RefSeq) compare
b1690 ydiM -0.6 -0.4 predicted transporter (NCBI) compare
b1258 yciF -0.6 -0.4 hypothetical protein (NCBI) compare
b4640 yoeG -0.6 -0.9 no description compare
b0178 hlpA -0.6 -1.8 periplasmic chaperone (NCBI) compare
b4431 rprA -0.6 -1.1 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b2576 srmB -0.6 -1.5 ATP-dependent RNA helicase (NCBI) compare
b1634 tppB -0.6 -2.3 putative tripeptide transporter permease (NCBI) compare
b1382 ynbE -0.6 -1.1 predicted lipoprotein (NCBI) compare
b0761 modE -0.6 -3.0 DNA-binding transcriptional dual regulator (NCBI) compare
b3650 spoT -0.6 -3.2 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) compare
b2017 yefM -0.6 -0.9 orf, hypothetical protein (VIMSS) compare
b0890 ftsK -0.6 -1.2 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b1344 ydaO -0.6 -1.3 predicted C32 tRNA thiolase (NCBI) compare
b0088 murD -0.6 -1.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b2868 xdhC -0.6 -3.9 xanthine dehydrogenase, Fe-S binding subunit (NCBI) compare
b0535 fimZ -0.6 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2274 yfbO -0.6 -1.9 predicted protein (RefSeq) compare
b2081 yegQ -0.6 -3.4 predicted peptidase (NCBI) compare
b2313 cvpA -0.6 -2.2 membrane protein required for colicin V production (NCBI) compare
b1831 proQ -0.6 -1.8 putative solute/DNA competence effector (NCBI) compare
b1222 narX -0.6 -2.2 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b1875 yecM -0.6 -2.3 orf, hypothetical protein (VIMSS) compare
b3617 kbl -0.6 -3.0 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Tetracycline hydrochloride across organisms