Experiment set9IT052 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Nitrofurantoin 0.000015625 mM

200 most important genes:

  gene name fitness t score description  
b0902 pflA -5.8 -4.0 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b0903 pflB -4.6 -9.4 pyruvate formate lyase I (NCBI) compare
b4058 uvrA -4.3 -19.9 excinuclease ABC subunit A (NCBI) conserved
b1334 fnr -4.1 -2.8 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b0779 uvrB -4.1 -10.5 excinuclease ABC subunit B (NCBI) conserved
b4201 priB -3.9 -2.7 primosomal replication protein N (NCBI) compare
b3930 menA -3.9 -17.6 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b2688 gshA -3.6 -7.3 glutamate--cysteine ligase (NCBI) compare
b0472 recR -3.5 -9.3 recombination protein RecR (NCBI) conserved
b2565 recO -3.5 -7.0 DNA repair protein RecO (NCBI) conserved
b1429 tehA -3.5 -2.3 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b4237 nrdG -3.4 -11.9 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b1524 yneH -3.3 -1.4 predicted glutaminase (NCBI) compare
b4238 nrdD -3.3 -18.8 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b2947 gshB -3.3 -3.2 glutathione synthetase (NCBI) compare
b1913 uvrC -3.2 -8.7 excinuclease ABC, subunit C; repair of UV damage to DNA (VIMSS) conserved
b3700 recF -3.0 -13.0 recombination protein F (NCBI) conserved
b4025 pgi -3.0 -8.6 glucose-6-phosphate isomerase (NCBI) compare
b3857 mobA -3.0 -7.9 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b1850 eda -3.0 -2.8 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase (NCBI) compare
b2501 ppk -2.9 -9.0 polyphosphate kinase (NCBI) compare
b3237 argR -2.9 -4.8 arginine repressor (NCBI) compare
b1677 lpp -2.9 -3.3 murein lipoprotein (NCBI) compare
b0729 sucD -2.8 -4.5 succinyl-CoA synthetase subunit alpha (NCBI) compare
b0623 cspE -2.7 -2.2 cold shock protein E (NCBI) compare
b3164 pnp -2.6 -2.5 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b0728 sucC -2.6 -7.0 succinyl-CoA synthetase subunit beta (NCBI) compare
b0785 moaE -2.6 -4.4 molybdopterin synthase, large subunit (NCBI) compare
b1346 ydaQ -2.6 -1.7 orf, hypothetical protein (VIMSS) compare
b3836 b3836 -2.6 -6.5 orf, hypothetical protein (VIMSS) compare
b0908 aroA -2.6 -8.2 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b0145 dksA -2.5 -2.4 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b0783 moaC -2.5 -6.7 molybdenum cofactor biosynthesis protein C (NCBI) compare
b3617 kbl -2.5 -7.5 2-amino-3-ketobutyrate coenzyme A ligase (NCBI) compare
b0049 apaH -2.4 -3.2 diadenosinetetraphosphatase (NCBI) compare
b2168 fruK -2.4 -1.5 1-phosphofructokinase (NCBI) compare
b1954 dsrA -2.3 -2.7 regulatory antisense RNA (NCBI) compare
b3839 tatC -2.3 -6.4 TatABCE protein translocation system subunit (NCBI) compare
b3253 yhdH -2.3 -9.8 predicted oxidoreductase, Zn-dependent and NAD(P)-binding (NCBI) compare
b1753 ynjA -2.3 -2.3 hypothetical protein (NCBI) compare
b0053 surA -2.3 -5.2 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b3792 wzxE -2.3 -5.8 O-antigen translocase (NCBI) compare
b2620 smpB -2.3 -1.5 SsrA-binding protein (NCBI) compare
b2579 yfiD -2.3 -2.6 pyruvate formate lyase subunit (NCBI) compare
b0737 tolQ -2.3 -2.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b2576 srmB -2.2 -3.3 ATP-dependent RNA helicase (NCBI) compare
b0763 modA -2.2 -6.3 molybdate transporter subunit (NCBI) compare
b0740 tolB -2.2 -3.3 translocation protein TolB precursor (NCBI) compare
b0741 pal -2.2 -3.6 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b0784 moaD -2.2 -3.1 molybdopterin synthase, small subunit (NCBI) compare
b3390 aroK -2.2 -2.0 shikimate kinase I (NCBI) compare
b3021 ygiT -2.2 -2.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b4138 dcuA -2.2 -10.6 C4-dicarboxylate antiporter (NCBI) compare
b0826 moeB -2.1 -6.5 molybdopterin biosynthesis protein MoeB (NCBI) compare
b0088 murD -2.1 -2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b0781 moaA -2.1 -7.3 molybdenum cofactor biosynthesis protein A (NCBI) compare
b4402 yjjY -2.1 -1.2 hypothetical protein (NCBI) compare
b0014 dnaK -2.1 -2.3 molecular chaperone DnaK (NCBI) compare
b2830 nudH -2.0 -1.3 dinucleoside polyphosphate hydrolase (NCBI) compare
b4175 hflC -2.0 -8.5 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b0764 modB -2.0 -4.3 molybdate ABC transporter permease protein (NCBI) compare
b0765 modC -2.0 -6.5 molybdate transporter subunit (NCBI) compare
b3652 recG -2.0 -8.0 ATP-dependent DNA helicase (NCBI) compare
b1175 minD -2.0 -4.0 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b2329 aroC -2.0 -5.2 chorismate synthase (NCBI) compare
b4535 yniD -2.0 -1.3 predicted protein (RefSeq) compare
b3500 gor -2.0 -1.3 glutathione reductase (NCBI) compare
b1476 fdnI -2.0 -0.8 formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible (NCBI) compare
b0009 mog -1.9 -6.5 molybdenum cofactor biosynthesis protein (NCBI) compare
b1818 manY -1.9 -2.2 mannose-specific enzyme IIC component of PTS (NCBI) compare
b0605 ahpC -1.9 -4.2 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b3838 tatB -1.9 -8.0 sec-independent translocase (NCBI) compare
b3229 sspA -1.8 -2.4 stringent starvation protein A (NCBI) compare
b1830 prc -1.8 -4.6 carboxy-terminal protease for penicillin-binding protein 3 (NCBI) compare
b3616 tdh -1.8 -5.5 L-threonine 3-dehydrogenase (NCBI) compare
b3408 feoA -1.8 -10.4 ferrous iron transport protein A (NCBI) compare
b4557 yidD -1.8 -3.5 hypothetical protein (NCBI) compare
b0739 tolA -1.8 -1.7 cell envelope integrity inner membrane protein TolA (NCBI) compare
b1942 fliJ -1.8 -1.3 flagellar biosynthesis chaperone (NCBI) compare
b3409 feoB -1.8 -13.4 ferrous iron transport protein B (NCBI) compare
b4260 pepA -1.8 -9.9 leucyl aminopeptidase (NCBI) compare
b2261 menC -1.8 -5.9 O-succinylbenzoate synthase (NCBI) compare
b3183 obgE -1.8 -1.1 GTPase involved in cell partioning and DNA repair (NCBI) compare
b3813 uvrD -1.8 -10.8 DNA-dependent ATPase I and helicase II (NCBI) compare
b4503 yafF -1.7 -1.0 no description compare
b3726 pstA -1.7 -4.0 phosphate transporter subunit (NCBI) compare
b0239 frsA -1.7 -4.6 fermentation/respiration switch protein (NCBI) compare
b3871 bipA -1.7 -8.6 GTP-binding protein (NCBI) compare
b3469 zntA -1.7 -5.4 zinc, cobalt and lead efflux system (NCBI) compare
b0222 lpcA -1.7 -2.8 phosphoheptose isomerase (NCBI) compare
b0218 yafU -1.7 -1.9 predicted inner membrane protein (RefSeq) compare
b1936 intG -1.7 -1.1 predicted defective phage integrase (pseudogene) (RefSeq) compare
b3163 nlpI -1.6 -4.6 hypothetical protein (NCBI) compare
b4139 aspA -1.6 -8.3 aspartate ammonia-lyase (aspartase) (VIMSS) compare
b3619 rfaD -1.6 -2.7 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b1273 yciN -1.6 -1.4 hypothetical protein (NCBI) compare
b0386 proC -1.6 -4.6 pyrroline-5-carboxylate reductase (NCBI) compare
b0738 tolR -1.6 -1.5 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b4450 arcZ -1.6 -2.6 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b0149 mrcB -1.6 -10.0 penicillin-binding protein 1b (NCBI) compare
b0406 tgt -1.6 -5.7 queuine tRNA-ribosyltransferase (NCBI) compare
b0912 ihfB -1.6 -2.7 integration host factor subunit beta (NCBI) compare
b2243 glpC -1.6 -6.6 sn-glycerol-3-phosphate dehydrogenase (anaerobic), small subunit (NCBI) compare
b0471 ybaB -1.6 -2.2 hypothetical protein (NCBI) compare
b0237 pepD -1.5 -6.8 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b3650 spoT -1.5 -6.2 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) compare
b2262 menB -1.5 -4.2 naphthoate synthase (NCBI) compare
b2259 pmrD -1.5 -1.0 polymyxin resistance protein B (VIMSS) compare
b3349 slyD -1.5 -5.8 FKBP-type peptidyl prolyl cis-trans isomerase (rotamase) (NCBI) compare
b0688 pgm -1.5 -2.8 phosphoglucomutase (NCBI) compare
b1503 ydeR -1.5 -2.5 predicted fimbrial-like adhesin protein (NCBI) compare
b4174 hflK -1.5 -6.8 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b1863 ruvC -1.5 -1.0 Holliday junction resolvase (NCBI) compare
b2330 yfcB -1.5 -1.0 putative adenine-specific methylase (VIMSS) compare
b0143 pcnB -1.5 -4.3 poly(A) polymerase I (VIMSS) compare
b4179 vacB -1.5 -4.7 putative enzyme (VIMSS) compare
b4435 isrC -1.5 -1.8 unknown RNA (NCBI) compare
b0730 mngR -1.5 -1.0 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b0827 moeA -1.5 -4.2 molybdopterin biosynthesis protein (NCBI) compare
b4053 alr -1.5 -7.1 alanine racemase (NCBI) compare
b4153 frdB -1.4 -5.4 fumarate reductase (anaerobic), Fe-S subunit (NCBI) compare
b3162 deaD -1.4 -2.5 inducible ATP-independent RNA helicase (VIMSS) compare
b2181 yejG -1.4 -3.7 hypothetical protein (NCBI) compare
b4431 rprA -1.4 -1.9 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b1048 mdoG -1.4 -4.5 glucan biosynthesis protein, periplasmic (NCBI) compare
b1874 cutC -1.4 -2.3 copper homeostasis protein (NCBI) compare
b3761 trpT -1.4 -1.5 tRNA-Trp (NCBI) compare
b1348 lar -1.4 -1.5 Rac prophage; restriction alleviation protein (NCBI) compare
b2241 glpA -1.4 -8.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit, FAD/NAD(P)-binding (NCBI) compare
b1907 tyrP -1.4 -3.9 tyrosine transporter (NCBI) compare
b1108 ycfP -1.4 -1.9 orf, hypothetical protein (VIMSS) compare
b4414 tff -1.4 -3.0 unknown RNA (NCBI) compare
b3868 glnG -1.4 -4.2 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b3075 ebgR -1.4 -3.7 DNA-binding transcriptional repressor (NCBI) compare
b2569 lepA -1.3 -3.1 GTP-binding protein LepA (NCBI) compare
b3727 pstC -1.3 -4.6 phosphate transporter subunit (NCBI) compare
b4648 ysaC -1.3 -2.4 no description compare
b0436 tig -1.3 -5.4 trigger factor (NCBI) compare
b3032 cpdA -1.3 -5.6 cyclic 3',5'-adenosine monophosphate phosphodiesterase (NCBI) compare
b2531 iscR -1.3 -1.2 DNA-binding transcriptional repressor (NCBI) compare
b0685 ybfE -1.3 -2.1 orf, hypothetical protein (VIMSS) compare
b3035 tolC -1.3 -6.5 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b1676 pykF -1.3 -3.1 pyruvate kinase (NCBI) compare
b3247 cafA -1.3 -7.1 bundles of cytoplasmic filaments (VIMSS) compare
b3368 cysG -1.3 -9.2 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) compare
b3791 rffA -1.3 -5.6 TDP-4-oxo-6-deoxy-D-glucose transaminase (NCBI) compare
b4181 yjfI -1.3 -1.9 hypothetical protein (NCBI) compare
b1380 ldhA -1.3 -1.5 D-lactate dehydrogenase (NCBI) compare
b2479 gcvR -1.3 -4.1 transcriptional regulation of gcv operon (VIMSS) compare
b3781 trxA -1.3 -3.2 thioredoxin 1 (VIMSS) compare
b1591 b1591 -1.3 -1.7 putative oxidoreductase component (VIMSS) compare
b1147 ymfL -1.3 -2.2 e14 prophage; predicted DNA-binding transcriptional regulator (RefSeq) compare
b2237 inaA -1.3 -3.1 hypothetical protein (NCBI) compare
b1607 ydgC -1.3 -1.3 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b1192 ldcA -1.3 -3.5 L,D-carboxypeptidase A (NCBI) compare
b4594 ymgJ -1.3 -1.8 hypothetical protein (RefSeq) compare
b3609 secB -1.3 -3.3 export protein SecB (NCBI) compare
b2362 yfdS -1.3 -3.9 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b0226 dinJ -1.3 -3.4 predicted antitoxin of YafQ-DinJ toxin-antitoxin system (NCBI) compare
b3026 qseC -1.3 -2.0 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b3753 rbsR -1.2 -7.0 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b3613 yibP -1.2 -0.8 putative membrane protein (VIMSS) compare
b3931 hslU -1.2 -6.3 ATP-dependent protease ATP-binding subunit (NCBI) compare
b1095 fabF -1.2 -5.8 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2313 cvpA -1.2 -3.7 membrane protein required for colicin V production (NCBI) compare
b1269 rluB -1.2 -2.7 23S rRNA pseudouridylate synthase (NCBI) compare
b4383 deoB -1.2 -5.1 phosphopentomutase (NCBI) compare
b1049 mdoH -1.2 -6.3 glucosyltransferase MdoH (NCBI) compare
b4460 araH -1.2 -2.1 fused L-arabinose transporter subunits of ABC superfamily: membrane components (RefSeq) compare
b1506 yneL -1.2 -1.2 predicted transcriptional regulator (NCBI) compare
b4509 ylcG -1.2 -2.3 DLP12 prophage; predicted protein (NCBI) compare
b0888 trxB -1.2 -2.4 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b3790 rffC -1.2 -4.4 TDP-fucosamine acetyltransferase (RefSeq) compare
b1161 ycgX -1.2 -0.8 hypothetical protein (NCBI) compare
b3741 gidA -1.2 -1.1 glucose-inhibited division protein A (NCBI) compare
b1970 yedX -1.2 -2.8 hypothetical protein (NCBI) compare
b2101 yegW -1.2 -3.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1824 yobF -1.2 -2.5 hypothetical protein (NCBI) compare
b0542 renD -1.2 -1.1 orf, hypothetical protein (VIMSS) compare
b0212 gloB -1.1 -2.1 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b1575 dicB -1.1 -1.0 Qin prophage; cell division inhibition protein (NCBI) compare
b4045 yjbJ -1.1 -2.4 predicted stress response protein (NCBI) compare
b1125 potB -1.1 -3.4 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b4152 frdC -1.1 -3.1 fumarate reductase subunit C (NCBI) compare
b0407 yajC -1.1 -1.4 preprotein translocase subunit YajC (NCBI) compare
b3912 cpxR -1.1 -4.4 DNA-binding response regulator in two-component regulatory system with CpxA (NCBI) compare
b2506 yfgI -1.1 -2.1 hypothetical protein (NCBI) compare
b1064 grxB -1.1 -4.3 glutaredoxin 2 (Grx2) (NCBI) compare
b1361 ydaW -1.1 -0.4 orf, hypothetical protein (VIMSS) compare
b2264 menD -1.1 -4.5 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase (NCBI) compare
b3002 yqhA -1.1 -1.9 hypothetical protein (NCBI) compare
b2937 speB -1.1 -4.7 agmatinase (NCBI) compare
b3466 yhhL -1.1 -3.0 conserved inner membrane protein (NCBI) compare
b4701 sokX -1.1 -0.6 sok-related sRNA, function unknown (RefSeq) compare
b2859 ygeO -1.1 -1.5 hypothetical protein (RefSeq) compare
b4180 rlmB -1.1 -5.1 23S rRNA (Gm2251)-methyltransferase (NCBI) compare
b3932 hslV -1.1 -5.2 ATP-dependent protease peptidase subunit (NCBI) compare
b1905 ftn -1.1 -5.4 ferritin iron storage protein (cytoplasmic) (NCBI) compare
b4171 miaA -1.1 -1.9 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b4702 mgtL -1.1 -1.5 regulatory leader peptide for mgtA (NCBI) compare


Specific Phenotypes

For 22 genes in this experiment

For stress Nitrofurantoin in Escherichia coli BW25113

For stress Nitrofurantoin across organisms