Experiment set8IT014 for Escherichia coli BW25113

Compare to:

LB Aerobic with Zinc Pyrithione 0.00000125 mM

200 most important genes:

  gene name fitness t score description  
b3292 zntR -2.4 -1.7 zinc-responsive transcriptional regulator (NCBI) compare
b1865 nudB -2.4 -2.1 dATP pyrophosphohydrolase (NCBI) compare
b3469 zntA -2.2 -3.7 zinc, cobalt and lead efflux system (NCBI) compare
b3341 rpsG -2.1 -1.9 30S ribosomal protein S7 (NCBI) compare
b1293 sapB -2.1 -1.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b0142 folK -2.1 -1.2 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b0726 sucA -2.0 -4.0 alpha-ketoglutarate decarboxylase (NCBI) compare
b1231 tyrT -2.0 -1.6 tRNA-Tyr (NCBI) compare
b1861 ruvA -1.9 -1.7 Holliday junction DNA helicase motor protein (NCBI) compare
b2279 nuoK -1.8 -2.2 NADH dehydrogenase subunit K (NCBI) compare
b0738 tolR -1.7 -2.7 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0053 surA -1.7 -3.5 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b0730 mngR -1.7 -1.1 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b1480 sra -1.7 -1.7 30S ribosomal subunit protein S22 (NCBI) compare
b1575 dicB -1.6 -1.9 Qin prophage; cell division inhibition protein (NCBI) compare
b2168 fruK -1.6 -1.9 1-phosphofructokinase (NCBI) compare
b2318 truA -1.6 -2.7 tRNA pseudouridine synthase A (NCBI) compare
b1291 sapD -1.5 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2258 b2258 -1.5 -1.8 putative transport/receptor protein (VIMSS) compare
b3390 aroK -1.5 -1.4 shikimate kinase I (NCBI) compare
b4202 rpsR -1.5 -1.0 30S ribosomal protein S18 (NCBI) compare
b1506 yneL -1.5 -1.5 predicted transcriptional regulator (NCBI) compare
b3500 gor -1.5 -1.6 glutathione reductase (NCBI) compare
b3962 udhA -1.4 -5.2 putative oxidoreductase (VIMSS) compare
b4503 yafF -1.4 -0.9 no description compare
b1523 yneG -1.4 -2.7 hypothetical protein (NCBI) compare
b3052 rfaE -1.4 -4.1 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) compare
b3649 rpoZ -1.4 -2.6 DNA-directed RNA polymerase subunit omega (NCBI) compare
b2282 nuoH -1.3 -2.8 NADH dehydrogenase subunit H (NCBI) compare
b1290 sapF -1.3 -1.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1677 lpp -1.3 -1.4 murein lipoprotein (NCBI) compare
b3619 rfaD -1.3 -2.2 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b3229 sspA -1.2 -1.7 stringent starvation protein A (NCBI) compare
b2432 yfeY -1.2 -1.9 hypothetical protein (NCBI) compare
b0505 allA -1.2 -3.5 ureidoglycolate hydrolase (NCBI) compare
b1686 ydiI -1.2 -2.2 hypothetical protein (NCBI) compare
b3761 trpT -1.2 -1.9 tRNA-Trp (NCBI) compare
b1370 insH-5 -1.2 -2.1 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b1286 rnb -1.2 -2.0 exoribonuclease II (NCBI) compare
b0989 cspH -1.2 -1.7 stress protein, member of the CspA-family (NCBI) compare
b0688 pgm -1.1 -2.3 phosphoglucomutase (NCBI) compare
b3620 rfaF -1.1 -3.6 ADP-heptose:LPS heptosyltransferase II (NCBI) compare
b2363 yfdT -1.1 -1.7 CPS-53 (KpLE1) prophage; predicted protein (NCBI) compare
b4598 yncL -1.1 -2.5 hypothetical protein (RefSeq) compare
b1882 cheY -1.1 -0.8 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b2814 metZ -1.1 -1.7 tRNA-Met (NCBI) compare
b3621 rfaC -1.1 -3.4 ADP-heptose:LPS heptosyl transferase I (NCBI) compare
b0439 lon -1.1 -3.4 DNA-binding ATP-dependent protease La (NCBI) compare
b0407 yajC -1.1 -2.2 preprotein translocase subunit YajC (NCBI) compare
b1863 ruvC -1.1 -1.6 Holliday junction resolvase (NCBI) compare
b3405 ompR -1.1 -4.8 osmolarity response regulator (NCBI) compare
b1482 osmC -1.1 -1.8 osmotically inducible, stress-inducible membrane protein (NCBI) compare
b0990 cspG -1.0 -0.6 DNA-binding transcriptional regulator (NCBI) compare
b4596 yciZ -1.0 -1.7 hypothetical protein (RefSeq) compare
b1105 ycfM -1.0 -3.5 predicted outer membrane lipoprotein (NCBI) compare
b3414 gntY -1.0 -3.6 predicted gluconate transport associated protein (NCBI) compare
b2376 ypdI -1.0 -2.0 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b2830 nudH -1.0 -0.9 dinucleoside polyphosphate hydrolase (NCBI) compare
b3029 ygiN -1.0 -1.4 quinol monooxygenase (NCBI) compare
b1765 ydjA -1.0 -1.1 predicted oxidoreductase (NCBI) compare
b4676 yoaK -1.0 -0.7 expressed protein (RefSeq) compare
b4529 ydbJ -1.0 -1.1 hypothetical protein (NCBI) compare
b4413 sokC -1.0 -1.7 regulatory antisense RNA (NCBI) compare
b2479 gcvR -0.9 -3.2 transcriptional regulation of gcv operon (VIMSS) compare
b1348 lar -0.9 -1.5 Rac prophage; restriction alleviation protein (NCBI) compare
b1503 ydeR -0.9 -1.9 predicted fimbrial-like adhesin protein (NCBI) compare
b1531 marA -0.9 -2.4 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b3026 qseC -0.9 -2.2 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b4640 yoeG -0.9 -1.3 no description compare
b0125 hpt -0.9 -3.6 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b1762 b1762 -0.9 -1.5 orf, hypothetical protein (VIMSS) compare
b2288 nuoA -0.9 -1.5 NADH dehydrogenase I chain A (VIMSS) compare
b1536 ydeI -0.9 -0.6 hypothetical protein (NCBI) compare
b0149 mrcB -0.9 -6.5 penicillin-binding protein 1b (NCBI) compare
b2808 gcvA -0.9 -2.5 DNA-binding transcriptional dual regulator (NCBI) compare
b0683 fur -0.9 -1.1 ferric uptake regulator (NCBI) compare
b3844 fre -0.9 -3.6 NAD(P)H-flavin reductase (NCBI) compare
b2688 gshA -0.9 -4.0 glutamate--cysteine ligase (NCBI) compare
b1951 rcsA -0.9 -0.6 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b3839 tatC -0.9 -4.0 TatABCE protein translocation system subunit (NCBI) compare
b1505 ydeT -0.9 -0.9 hypothetical protein (RefSeq) compare
b3181 greA -0.9 -2.9 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b1877 yecT -0.8 -1.1 orf, hypothetical protein (VIMSS) compare
b1773 ydjI -0.8 -0.7 predicted aldolase (NCBI) compare
b3630 rfaP -0.8 -4.5 kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) compare
b4519 icdC -0.8 -2.6 no description compare
b0200 gmhB -0.8 -0.5 hypothetical protein (NCBI) compare
b1684 sufA -0.8 -1.8 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b1258 yciF -0.8 -0.5 hypothetical protein (NCBI) compare
b1690 ydiM -0.8 -0.7 predicted transporter (NCBI) compare
b2445 yffN -0.8 -1.7 CPZ-55 prophage; predicted protein (RefSeq) compare
b1309 ycjM -0.8 -1.9 putative polysaccharide hydrolase (VIMSS) compare
b1502 ydeQ -0.8 -1.0 predicted fimbrial-like adhesin protein (NCBI) compare
b0706 ybfD -0.8 -1.0 hypothetical protein (NCBI) compare
b1691 ydiN -0.8 -1.4 predicted transporter (RefSeq) compare
b3706 trmE -0.8 -1.7 tRNA modification GTPase (NCBI) compare
b1576 ydfD -0.8 -0.4 Qin prophage; predicted protein (NCBI) compare
b1008 ycdI -0.7 -2.2 hypothetical protein (NCBI) compare
b1454 yncG -0.7 -1.4 predicted enzyme (NCBI) compare
b0429 cyoD -0.7 -2.6 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b3204 ptsN -0.7 -2.6 sugar-specific enzyme IIA component of PTS (NCBI) compare
b3652 recG -0.7 -4.2 ATP-dependent DNA helicase (NCBI) compare
b3183 obgE -0.7 -0.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b0957 ompA -0.7 -1.9 outer membrane protein A (3a;II*;G;d) (NCBI) compare
b4178 yjeB -0.7 -2.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1742 b1742 -0.7 -1.5 orf, hypothetical protein (VIMSS) compare
b3631 rfaG -0.7 -5.2 glucosyltransferase I (NCBI) compare
b1917 yecC -0.7 -2.0 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b1192 ldcA -0.7 -2.6 L,D-carboxypeptidase A (NCBI) compare
b0685 ybfE -0.7 -1.6 orf, hypothetical protein (VIMSS) compare
b1622 malY -0.7 -2.7 bifunctional beta-cystathionase, PLP-dependent/ regulator of maltose regulon (NCBI) compare
b1377 ompN -0.7 -2.6 outer membrane pore protein N, non-specific (NCBI) compare
b4603 rseX -0.7 -0.5 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b1860 ruvB -0.7 -0.7 Holliday junction DNA helicase B (NCBI) compare
b1130 phoP -0.7 -0.4 DNA-binding response regulator in two-component regulatory system with PhoQ (NCBI) compare
b0484 copA -0.7 -5.1 copper transporter (NCBI) compare
b1785 yeaI -0.7 -1.1 predicted diguanylate cyclase (NCBI) compare
b0605 ahpC -0.7 -2.1 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b0890 ftsK -0.7 -1.3 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b2569 lepA -0.7 -1.5 GTP-binding protein LepA (NCBI) compare
b0836 yliH -0.7 -1.9 hypothetical protein (NCBI) compare
b1409 ynbB -0.7 -0.4 predicted CDP-diglyceride synthase (NCBI) compare
b1040 csgD -0.7 -0.7 DNA-binding transcriptional activator in two-component regulatory system (NCBI) compare
b4585 sroB -0.7 -1.0 Novel sRNA, function unknown (RefSeq) compare
b4701 sokX -0.7 -0.7 sok-related sRNA, function unknown (RefSeq) compare
b1579 intQ -0.7 -1.3 Qin prophage; predicted defective integrase (RefSeq) compare
b4407 thiS -0.7 -1.2 sulfur carrier protein ThiS (NCBI) compare
b0088 murD -0.7 -1.3 UDP-N-acetylmuramoyl-L-alanyl-D-glutamatesynthetase (NCBI) compare
b1839 yebY -0.7 -1.6 hypothetical protein (NCBI) compare
b2512 yfgL -0.7 -2.7 protein assembly complex, lipoprotein component (NCBI) compare
b2450 yffS -0.7 -1.3 CPZ-55 prophage; predicted protein (RefSeq) compare
b1182 hlyE -0.7 -0.4 hemolysin E (VIMSS) compare
b3742 mioC -0.7 -1.9 flavodoxin (NCBI) compare
b1648 b1648 -0.7 -1.2 orf, hypothetical protein (VIMSS) compare
b4181 yjfI -0.7 -1.4 hypothetical protein (NCBI) compare
b0406 tgt -0.7 -3.1 queuine tRNA-ribosyltransferase (NCBI) compare
b4595 yciY -0.7 -1.2 hypothetical protein (RefSeq) compare
b0741 pal -0.7 -1.6 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b2111 yehD -0.7 -1.3 predicted fimbrial-like adhesin protein (NCBI) compare
b4179 vacB -0.7 -2.4 putative enzyme (VIMSS) compare
b1165 ymgA -0.6 -0.4 hypothetical protein (NCBI) compare
b0340 cynS -0.6 -1.8 cyanate hydratase (NCBI) compare
b0778 bioD -0.6 -2.1 dethiobiotin synthetase (NCBI) compare
b3035 tolC -0.6 -3.6 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0737 tolQ -0.6 -1.0 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b3613 yibP -0.6 -1.2 putative membrane protein (VIMSS) compare
b2297 pta -0.6 -0.4 phosphate acetyltransferase (NCBI) compare
b1671 ydhX -0.6 -1.6 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b4527 b1354 -0.6 -2.3 orf, hypothetical protein (VIMSS) compare
b2330 yfcB -0.6 -0.7 putative adenine-specific methylase (VIMSS) compare
b1735 chbR -0.6 -1.3 DNA-binding transcriptional dual regulator (NCBI) compare
b3629 rfaS -0.6 -1.1 lipopolysaccharide core biosynthesis protein (NCBI) compare
b4497 yeeL -0.6 -0.5 no description compare
b0722 sdhD -0.6 -2.2 succinate dehydrogenase cytochrome b556 small membrane subunit (NCBI) compare
b1025 ycdT -0.6 -0.7 predicted diguanylate cyclase (NCBI) compare
b3237 argR -0.6 -1.9 arginine repressor (NCBI) compare
b1567 intK -0.6 -1.2 Qin prophage; predicted protein (RefSeq) compare
b1347 ydaC -0.6 -0.3 Rac prophage; predicted protein (NCBI) compare
b1168 b1168 -0.6 -1.5 putative proteases (VIMSS) compare
b0648 ybeU -0.6 -2.9 predicted tRNA ligase (NCBI) compare
b2252 ais -0.6 -1.6 hypothetical protein (NCBI) compare
b1351 racC -0.6 -0.3 Rac prophage; predicted protein (NCBI) compare
b4208 cycA -0.6 -3.8 D-alanine/D-serine/glycine transporter (NCBI) compare
b1363 trkG -0.6 -0.3 Rac prophage; potassium transporter subunit (NCBI) compare
b1551 b1551 -0.6 -0.3 orf, hypothetical protein (VIMSS) compare
b2457 cchA -0.6 -1.9 detox protein (VIMSS) compare
b1497 b1497 -0.6 -0.3 putative enzyme (VIMSS) compare
b1499 ydeO -0.6 -0.3 predicted DNA-binding transcriptional acfivator (NCBI) compare
b3636 rpmG -0.6 -0.8 50S ribosomal protein L33 (NCBI) compare
b3766 ilvL -0.6 -1.7 ilvG operon leader peptide (NCBI) compare
b2061 wzb -0.6 -1.4 protein-tyrosine phosphatase (NCBI) compare
b2504 yfgG -0.6 -0.5 Negative regulator of nickel and cobalt uptake (YfgG) (from data) compare
b2915 yqfE -0.6 -1.6 hypothetical protein (RefSeq) compare
b1689 b1689 -0.6 -1.4 orf, hypothetical protein (VIMSS) compare
b2906 visC -0.6 -2.6 hypothetical protein (NCBI) compare
b3979 thrT -0.6 -0.3 tRNA-Thr (NCBI) compare
b4438 cyaR -0.6 -1.4 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b1545 pinQ -0.6 -0.3 Qin prophage; predicted site-specific recombinase (NCBI) compare
b1969 yedW -0.6 -1.3 putative 2-component transcriptional regulator (VIMSS) compare
b0934 ycbM -0.6 -1.6 putative transport system permease protein (VIMSS) compare
b0677 nagA -0.6 -2.4 N-acetylglucosamine-6-phosphate deacetylase (NCBI) compare
b2283 nuoG -0.6 -2.7 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2784 relA -0.6 -3.7 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b0237 pepD -0.6 -3.0 aminoacyl-histidine dipeptidase (peptidase D) (NCBI) compare
b4561 insM -0.6 -2.1 transposase (RefSeq) compare
b0678 nagB -0.6 -2.2 glucosamine-6-phosphate deaminase (NCBI) compare
b3563 yiaB -0.6 -1.5 orf, hypothetical protein (VIMSS) compare
b2085 b2085 -0.6 -1.4 orf, hypothetical protein (VIMSS) compare
b3842 rfaH -0.6 -2.2 transcriptional activator RfaH (NCBI) compare
b3169 nusA -0.6 -1.2 transcription elongation factor NusA (NCBI) compare
b2286 nuoC -0.5 -2.2 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b2369 evgA -0.5 -1.1 DNA-binding response regulator in two-component regulatory system with EvgS (NCBI) compare
b2055 wcaE -0.5 -0.3 predicted glycosyl transferase (NCBI) compare
b1257 yciE -0.5 -0.3 hypothetical protein (NCBI) compare
b2565 recO -0.5 -2.4 DNA repair protein RecO (NCBI) compare
b1159 mcrA -0.5 -0.4 e14 prophage; 5-methylcytosine-specific restriction endonuclease B (NCBI) compare
b4552 yrhC -0.5 -0.3 no description compare
b3803 hemX -0.5 -3.8 predicted uroporphyrinogen III methylase (NCBI) compare
b4234 yjgA -0.5 -2.1 hypothetical protein (NCBI) compare
b2340 sixA -0.5 -1.9 phosphohistidine phosphatase (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in stress experiments

For stress Zinc Pyrithione across organisms