Experiment set6S715 for Mycobacterium tuberculosis H37Rv

Compare to:

7H9 with Formaldehyde 0.23 mM

200 most important genes:

  gene name fitness t score description  
Rv0928 -2.9 -4.2 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) compare
Rv1178 -2.8 -4.0 Probable aminotransferase compare
Rv1633 -2.8 -14.9 Probable excinuclease ABC (subunit B-helicase) UvrB compare
Rv3477 -2.6 -1.7 PE family protein PE31 compare
Rv2259 -2.5 -2.7 S-nitrosomycothiol reductase MscR compare
Rv0819 -2.5 -4.9 GCN5-related N-acetyltransferase, MshD compare
Rv1638 -2.4 -6.9 Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA compare
Rv2887 -2.4 -1.8 Probable transcriptional regulatory protein compare
Rv1010 -2.3 -1.6 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) compare
Rv3819 -2.3 -0.9 Unknown protein compare
Rv3569c -2.2 -2.0 4,9-DHSA hydrolase compare
Rv1170 -2.2 -2.9 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) compare
Rv3277 -2.1 -0.9 Probable conserved transmembrane protein compare
Rv3419c -2.1 -1.9 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) compare
Rv1791 -2.0 -2.0 PE family protein PE19 compare
Rv1284 -2.0 -1.0 Beta-carbonic anhydrase compare
Rv3208A -1.9 -1.9 Conserved protein TB9.4 compare
Rv0949 -1.9 -0.8 Probable ATP-dependent DNA helicase II UvrD1 compare
Rv2647 -1.9 -2.1 Hypothetical protein compare
Rv2733c -1.8 -2.5 Conserved hypothetical alanine, arginine-rich protein compare
Rv0930 -1.8 -5.4 Probable phosphate-transport integral membrane ABC transporter PstA1 compare
Rv0472c -1.7 -4.0 Probable transcriptional regulatory protein (possibly TetR-family) compare
Rv3101c -1.7 -2.0 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) compare
Rv1693 -1.7 -1.8 Conserved hypothetical protein compare
Rv2696c -1.7 -2.6 Conserved alanine and glycine and valine rich protein compare
Rv3143 -1.7 -0.7 Probable response regulator compare
Rv3559c -1.6 -1.1 Probable oxidoreductase compare
Rv0609 -1.5 -1.2 Possible toxin VapC28. Contains PIN domain. compare
Rv3874 -1.5 -1.2 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) compare
Rv2869c -1.5 -1.4 Membrane bound metalloprotease compare
Rv2694c -1.5 -3.0 Conserved protein compare
Rv3162c -1.4 -1.5 Possible integral membrane protein compare
Rv0821c -1.4 -2.0 Probable phosphate-transport system transcriptional regulatory protein PhoY2 compare
Rv3046c -1.4 -0.8 Conserved protein compare
Rv1400c -1.4 -0.8 Probable lipase LipH compare
Rv1626 -1.4 -2.9 Probable two-component system transcriptional regulator compare
Rv0208c -1.4 -3.7 Hypothetical methlytransferase (methylase) compare
Rv3136 -1.4 -4.4 PPE family protein PPE51 compare
Rv2044c -1.4 -0.8 Conserved hypothetical protein compare
Rv0242c -1.4 -3.9 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) compare
Rv1420 -1.4 -1.6 Probable excinuclease ABC (subunit C-nuclease) UvrC compare
Rv2912c -1.4 -2.8 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3135 -1.4 -4.7 PPE family protein PPE50 compare
Rv0504c -1.3 -1.4 Conserved protein compare
Rv0758 -1.3 -2.5 Possible two component system response sensor kinase membrane associated PhoR compare
Rv2331A -1.3 -0.9 Hypothetical protein compare
Rv0989c -1.3 -7.0 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) compare
Rv1421 -1.3 -2.2 Conserved protein compare
Rv3478 -1.3 -4.2 PE family protein PPE60 compare
Rv0929 -1.3 -1.8 Phosphate-transport integral membrane ABC transporter PstC2 compare
Rv0019c -1.3 -4.3 Conserved protein with FHA domain, FhaB compare
Rv0757 -1.3 -1.3 Possible two component system response transcriptional positive regulator PhoP compare
Rv0241c -1.2 -2.3 Probable 3-hydroxyacyl-thioester dehydratase HtdX compare
Rv0818 -1.2 -4.0 Transcriptional regulatory protein compare
Rv1908c -1.2 -1.5 Catalase-peroxidase-peroxynitritase T KatG compare
Rv1798 -1.2 -1.1 ESX conserved component EccA5. ESX-5 type VII secretion system protein. compare
Rv3405c -1.2 -1.2 Possible transcriptional regulatory protein compare
Rv3810 -1.2 -2.0 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) compare
Rv1173 -1.2 -2.1 Probable F420 biosynthesis protein FbiC compare
Rv2569c -1.2 -4.1 Conserved hypothetical protein compare
Rv2322c -1.1 -1.2 Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) compare
Rv3855 -1.1 -4.1 Transcriptional regulatory repressor protein (TetR-family) EthR compare
Rv1013 -1.1 -5.3 Putative polyketide synthase Pks16 compare
Rv2691 -1.1 -5.6 TRK system potassium uptake protein CeoB compare
Rv0497 -1.1 -1.2 Probable conserved transmembrane protein compare
Rv1621c -1.1 -3.0 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD compare
Rv0622 -1.1 -2.3 Possible membrane protein compare
Rv2791c -1.1 -2.6 Probable transposase compare
Rv3222c -1.1 -1.0 Conserved hypothetical protein compare
Rv2003c -1.0 -0.9 Conserved hypothetical protein compare
Rv2007c -1.0 -1.3 Ferredoxin FdxA compare
Rv2277c -1.0 -1.6 Possible glycerolphosphodiesterase compare
Rv1148c -1.0 -1.3 Conserved hypothetical protein compare
Rv0674 -1.0 -0.6 Conserved hypothetical protein compare
Rv1821 -1.0 -2.5 Possible preprotein translocase ATPase SecA2 compare
Rv1620c -1.0 -2.2 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC compare
Rv2250c -1.0 -1.7 Possible transcriptional regulatory protein compare
Rv1624c -1.0 -2.2 Probable conserved membrane protein compare
Rv0452 -1.0 -2.1 Possible transcriptional regulatory protein compare
Rv0113 -1.0 -1.1 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) compare
Rv0324 -1.0 -2.0 Possible transcriptional regulatory protein (possibly ArsR-family) compare
Rv0018c -1.0 -2.5 Phosphoserine/threonine phosphatase PstP compare
Rv0323c -1.0 -1.6 Conserved hypothetical protein compare
Rv3311 -1.0 -2.9 Conserved protein compare
Rv0924c -1.0 -3.3 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) compare
Rv3920c -1.0 -0.9 Conserved protein similar to jag protein compare
Rv3223c -0.9 -2.6 Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE) compare
Rv1411c -0.9 -2.2 Conserved lipoprotein LprG compare
Rv1946c -0.9 -1.9 Possible lipoprotein compare
Rv1745c -0.9 -2.0 Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) compare
Rv3123 -0.9 -1.6 Hypothetical protein compare
Rv2709 -0.9 -2.8 Probable conserved transmembrane protein compare
Rv3770B -0.9 -1.6 Probable remnant of a transposase compare
Rv0009 -0.9 -0.7 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) compare
Rv0876c -0.9 -1.5 Possible conserved transmembrane protein compare
Rv1657 -0.9 -1.5 Probable arginine repressor ArgR (AHRC) compare
Rv3193c -0.9 -1.3 Probable conserved transmembrane protein compare
Rv0092 -0.9 -3.0 Cation transporter P-type ATPase a CtpA compare
Rv1398c -0.9 -1.4 Possible antitoxin VapB10 compare
Rv3139 -0.9 -2.9 Probable acyl-CoA dehydrogenase FadE24 compare
Rv3723 -0.9 -2.0 Probable conserved transmembrane protein compare
Rv1566c -0.9 -1.9 Possible Inv protein compare
Rv3081 -0.9 -0.8 Conserved hypothetical protein compare
Rv0017c -0.9 -2.8 Probable cell division protein RodA compare
Rv3102c -0.9 -1.9 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) compare
Rv1836c -0.9 -1.7 Conserved protein compare
Rv0983 -0.9 -3.0 Probable serine protease PepD (serine proteinase) (MTB32B) compare
Rv1049 -0.8 -1.4 Probable transcriptional repressor protein compare
Rv1410c -0.8 -3.7 Aminoglycosides/tetracycline-transport integral membrane protein compare
Rv0377 -0.8 -3.0 Probable transcriptional regulatory protein (probably LysR-family) compare
Rv0933 -0.8 -1.0 Phosphate-transport ATP-binding protein ABC transporter PstB compare
Rv2384 -0.8 -1.2 Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase compare
Rv0820 -0.8 -1.8 Probable phosphate-transport ATP-binding protein ABC transporter PhoT compare
Rv2500c -0.8 -0.8 Possible acyl-CoA dehydrogenase FadE19 (MMGC) compare
Rv0016c -0.8 -3.3 Probable penicillin-binding protein PbpA compare
Rv2680 -0.8 -0.8 Conserved protein compare
Rv3358 -0.8 -2.3 Toxin RelK compare
Rv2171 -0.8 -1.5 Probable conserved lipoprotein LppM compare
Rv2468c -0.8 -2.8 Conserved protein compare
Rv2567 -0.8 -2.7 Conserved hypothetical alanine and leucine rich protein compare
Rv1889c -0.8 -1.9 Conserved hypothetical protein compare
Rv3610c -0.8 -1.5 Membrane-bound protease FtsH (cell division protein) compare
Rv2382c -0.8 -0.8 Polyketide synthetase MbtC (polyketide synthase) compare
Rv0474 -0.8 -3.7 Probable transcriptional regulatory protein compare
Rv2772c -0.8 -0.8 Probable conserved transmembrane protein compare
Rv1691 -0.7 -1.2 Conserved hypothetical protein compare
Rv2028c -0.7 -1.4 Universal stress protein family protein compare
Rv1127c -0.7 -0.8 Probable pyruvate, phosphate dikinase PpdK compare
Rv2782c -0.7 -1.7 Probable zinc protease PepR compare
Rv0043c -0.7 -1.0 Probable transcriptional regulatory protein (probably GntR-family) compare
Rv1962A -0.7 -0.8 Possible antitoxin VapB35 compare
Rv3576 -0.7 -1.6 Possible conserved lipoprotein LppH compare
Rv3364c -0.7 -1.1 Conserved protein compare
Rv3488 -0.7 -1.0 Conserved hypothetical protein compare
Rv3675 -0.7 -1.9 Possible membrane protein compare
Rv0418 -0.7 -2.4 Probable lipoprotein aminopeptidase LpqL compare
Rv1259 -0.7 -0.7 Probable uracil DNA glycosylase, UdgB compare
Rv0927c -0.7 -1.2 Probable short-chain type dehydrogenase/reductase compare
Rv0399c -0.7 -1.7 Possible conserved lipoprotein LpqK compare
Rv3481c -0.7 -1.2 Probable integral membrane protein compare
Rv2708c -0.7 -2.1 Conserved hypothetical protein compare
Rv2863 -0.7 -2.3 Possible toxin VapC23 compare
Rv2793c -0.7 -0.5 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) compare
Rv0689c -0.7 -2.1 Hypothetical protein compare
Rv3919c -0.7 -1.8 Probable glucose-inhibited division protein B Gid compare
Rv1031 -0.7 -2.1 Probable potassium-transporting ATPase C chain KdpC (potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (potassium binding and translocating subunit C) compare
Rv3666c -0.7 -2.1 Probable periplasmic dipeptide-binding lipoprotein DppA compare
Rv2009 -0.7 -0.9 Antitoxin VapB15 compare
Rv2344c -0.7 -2.5 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) compare
Rv1021 -0.7 -1.1 Conserved protein compare
Rv1683 -0.7 -2.6 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase. compare
Rv2752c -0.7 -2.2 Conserved hypothetical protein compare
Rv3188 -0.7 -1.1 Conserved hypothetical protein compare
Rv3726 -0.7 -0.6 Possible dehydrogenase compare
Rv2260 -0.7 -1.0 Conserved hypothetical protein compare
Rv1020 -0.7 -3.6 Probable transcription-repair coupling factor Mfd (TRCF) compare
Rv0353 -0.7 -2.0 Probable heat shock protein transcriptional repressor HspR (MerR family) compare
Rv0145 -0.7 -2.3 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv1925 -0.7 -3.0 Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) compare
Rv0428c -0.6 -3.1 GCN5-related N-acetyltransferase compare
Rv2088 -0.6 -0.8 Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J) compare
Rv1335 -0.6 -1.7 Sulfur carrier protein CysO compare
Rv2583c -0.6 -1.7 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) compare
Rv0782 -0.6 -1.7 Probable protease II PtrBb [second part] (oligopeptidase B) compare
Rv2732c -0.6 -1.6 Probable conserved transmembrane protein compare
Rv0309 -0.6 -2.1 Possible conserved exported protein compare
Rv3010c -0.6 -2.4 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) compare
Rv3570c -0.6 -2.6 Possible oxidoreductase. Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase. compare
Rv0995 -0.6 -0.9 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) compare
Rv1100 -0.6 -1.9 Conserved protein compare
Rv3399 -0.6 -2.8 Possible S-adenosylmethionine-dependent methyltransferase compare
Rv3543c -0.6 -3.0 Probable acyl-CoA dehydrogenase FadE29 compare
Rv3262 -0.6 -1.4 Probable F420 biosynthesis protein FbiB compare
Rv0793 -0.6 -3.1 Possible monooxygenase compare
Rv3033 -0.6 -0.4 Unknown protein compare
Rv2618 -0.6 -2.4 Conserved hypothetical protein compare
Rv0653c -0.6 -2.4 Possible transcriptional regulatory protein (probably TetR-family) compare
Rv0398c -0.6 -1.5 Possible secreted protein compare
Rv3600c -0.6 -2.4 Conserved protein compare
Rv2173 -0.6 -1.9 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) compare
Rv1180 -0.6 -1.7 Probable polyketide beta-ketoacyl synthase Pks3 compare
Rv1159A -0.6 -1.0 Unknown protein compare
Rv3256c -0.6 -0.9 Conserved protein compare
Rv3803c -0.6 -3.0 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) compare
Rv2784c -0.6 -1.7 Probable lipoprotein LppU compare
Rv0188 -0.6 -0.7 Probable conserved transmembrane protein compare
Rv0959 -0.6 -0.5 Conserved hypothetical protein compare
Rv3910 -0.6 -0.9 Probable conserved transmembrane protein compare
Rv2506 -0.6 -1.4 Probable transcriptional regulatory protein (probably TetR-family) compare
Rv3862c -0.6 -2.3 Possible transcriptional regulatory protein WhiB-like WhiB6 compare
Rv0866 -0.6 -2.7 Probable molybdenum cofactor biosynthesis protein E2 MoaE2 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2) compare
Rv3667 -0.6 -2.7 Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase) compare
Rv0343 -0.6 -1.8 Isoniazid inductible gene protein IniC compare
Rv1377c -0.6 -2.3 Putative transferase compare
Rv0905 -0.6 -1.3 Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) compare
Rv2434c -0.6 -1.8 Probable conserved transmembrane protein compare
Rv0379 -0.6 -0.4 Possible protein transport protein SecE2 compare
Rv3066 -0.6 -2.1 Probable transcriptional regulatory protein (probably DeoR-family) compare
Rv2224c -0.6 -3.9 Probable carboxylesterase CaeA compare
Rv1450c -0.5 -0.9 PE-PGRS family protein PE_PGRS27 compare


Specific Phenotypes

For 2 genes in this experiment

For stress Formaldehyde in Mycobacterium tuberculosis H37Rv

For stress Formaldehyde across organisms