Experiment set40IT087 for Escherichia coli BW25113

Compare to:

carbon source D-Mannose 0.5mM

200 most important genes:

  gene name fitness t score description  
b1192 ldcA -10.4 -5.1 L,D-carboxypeptidase A (NCBI) compare
b4013 metA -8.7 -3.9 homoserine O-succinyltransferase (NCBI) compare
b0242 proB -8.5 -4.6 gamma-glutamyl kinase (NCBI) compare
b2020 hisD -8.4 -5.0 histidinol dehydrogenase (NCBI) compare
b1261 trpB -8.4 -2.2 tryptophan synthase subunit beta (NCBI) compare
b0074 leuA -8.2 -5.7 2-isopropylmalate synthase (NCBI) compare
b0243 proA -8.1 -5.6 gamma-glutamyl phosphate reductase (NCBI) compare
b3770 ilvE -8.1 -5.6 branched-chain amino acid aminotransferase (NCBI) compare
b3172 argG -8.1 -5.6 argininosuccinate synthase (NCBI) compare
b0032 carA -7.9 -4.3 carbamoyl-phosphate synthase small subunit (NCBI) compare
b0004 thrC -7.9 -5.5 threonine synthase (NCBI) compare
b1817 manX -7.8 -4.2 fused mannose-specific PTS enzymes: IIA component/IIB component (NCBI) conserved
b3956 ppc -7.7 -16.5 phosphoenolpyruvate carboxylase (NCBI) compare
b2021 hisC -7.6 -3.6 histidinol-phosphate aminotransferase (NCBI) compare
b2312 purF -7.4 -4.3 amidophosphoribosyltransferase (NCBI) compare
b0033 carB -7.4 -16.5 carbamoyl-phosphate synthase large subunit (NCBI) compare
b2762 cysH -7.2 -5.0 phosphoadenosine phosphosulfate reductase (NCBI) compare
b1281 pyrF -7.2 -2.6 orotidine 5'-phosphate decarboxylase (NCBI) compare
b4388 serB -7.2 -4.5 3-phosphoserine phosphatase (NCBI) compare
b2763 cysI -7.1 -4.9 sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) compare
b3389 aroB -7.1 -11.9 3-dehydroquinate synthase (NCBI) compare
b1818 manY -7.0 -1.8 mannose-specific enzyme IIC component of PTS (NCBI) compare
b2022 hisB -7.0 -4.5 imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) compare
b3773 ilvY -6.9 -12.2 DNA-binding transcriptional dual regulator (NCBI) compare
b0720 gltA -6.9 -4.5 citrate synthase (NCBI) compare
b2557 purL -6.9 -4.8 phosphoribosylformylglycinamidine synthase (NCBI) compare
b0522 purK -6.9 -4.8 phosphoribosylaminoimidazole carboxylase (NCBI) compare
b0523 purE -6.9 -2.5 phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) compare
b3957 argE -6.8 -13.5 acetylornithine deacetylase (NCBI) compare
b1819 manZ -6.8 -3.2 mannose-specific enzyme IID component of PTS (NCBI) conserved
b2025 hisF -6.7 -2.8 imidazole glycerol phosphate synthase subunit HisF (NCBI) compare
b3772 ilvA -6.7 -14.1 threonine dehydratase (NCBI) compare
b2818 argA -6.7 -9.0 N-acetylglutamate synthase (NCBI) compare
b2814 metZ -6.6 -1.0 tRNA-Met (NCBI) compare
b4006 purH -6.6 -14.8 bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) compare
b0737 tolQ -6.6 -3.4 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0386 proC -6.6 -4.4 pyrroline-5-carboxylate reductase (NCBI) compare
b2499 purM -6.5 -3.5 phosphoribosylaminoimidazole synthetase (NCBI) compare
b4245 pyrB -6.5 -7.7 aspartate carbamoyltransferase catalytic subunit (NCBI) compare
b1693 aroD -6.5 -3.9 3-dehydroquinate dehydratase (NCBI) compare
b2329 aroC -6.4 -4.1 chorismate synthase (NCBI) compare
b1563 relE -6.4 -1.7 Qin prophage; toxin of the RelE-RelB toxin-antitoxin system (NCBI) compare
b4005 purD -6.4 -11.9 phosphoribosylamine--glycine ligase (NCBI) compare
b3774 ilvC -6.4 -16.1 ketol-acid reductoisomerase (NCBI) compare
b0739 tolA -6.3 -4.2 cell envelope integrity inner membrane protein TolA (NCBI) compare
b3642 pyrE -6.2 -3.3 orotate phosphoribosyltransferase (NCBI) compare
b3281 aroE -6.0 -17.4 dehydroshikimate reductase, NAD(P)-binding (NCBI) compare
b3781 trxA -6.0 -3.0 thioredoxin 1 (VIMSS) compare
b0071 leuD -6.0 -6.2 isopropylmalate isomerase small subunit (NCBI) compare
b0072 leuC -6.0 -9.3 isopropylmalate isomerase large subunit (NCBI) compare
b3960 argH -5.9 -13.6 argininosuccinate lyase (NCBI) compare
b3941 metF -5.9 -7.7 5,10-methylenetetrahydrofolate reductase (NCBI) compare
b0001 thrL -5.9 -1.3 thr operon leader peptide (NCBI) compare
b3761 trpT -5.9 -0.9 tRNA-Trp (NCBI) compare
b1920 fliY -5.8 -1.7 cystine transporter subunit (NCBI) compare
b3237 argR -5.8 -5.2 arginine repressor (NCBI) compare
b1865 nudB -5.8 -1.5 dATP pyrophosphohydrolase (NCBI) compare
b0738 tolR -5.7 -3.6 membrane spanning protein in TolA-TolQ-TolR complex (NCBI) compare
b0908 aroA -5.7 -11.4 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) compare
b2024 hisA -5.6 -1.2 N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) compare
b4585 sroB -5.6 -0.8 Novel sRNA, function unknown (RefSeq) compare
b3939 metB -5.5 -8.6 cystathionine gamma-synthase (NCBI) compare
b3771 ilvD -5.5 -11.1 dihydroxy-acid dehydratase (NCBI) compare
b0002 thrA -5.5 -11.7 bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) compare
b0003 thrB -5.4 -6.4 homoserine kinase (NCBI) compare
b2600 tyrA -5.4 -5.4 fused chorismate mutase T/prephenate dehydrogenase (NCBI) compare
b3341 rpsG -5.4 -1.4 30S ribosomal protein S7 (NCBI) compare
b0907 serC -5.4 -4.6 phosphoserine aminotransferase (NCBI) compare
b4431 rprA -5.3 -1.6 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b1103 ycfF -5.3 -1.1 orf, hypothetical protein (VIMSS) compare
b2259 pmrD -5.3 -0.8 polymyxin resistance protein B (VIMSS) compare
b2750 cysC -5.2 -4.1 adenylylsulfate kinase (NCBI) compare
b1595 ynfL -5.2 -1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b2839 lysR -5.2 -4.9 DNA-binding transcriptional dual regulator (NCBI) compare
b2838 lysA -5.1 -7.2 diaminopimelate decarboxylase, PLP-binding (NCBI) compare
b3390 aroK -5.1 -1.9 shikimate kinase I (NCBI) compare
b0740 tolB -5.0 -8.3 translocation protein TolB precursor (NCBI) compare
b1613 manA -5.0 -2.0 mannose-6-phosphate isomerase (VIMSS) compare
b2913 serA -5.0 -6.8 D-3-phosphoglycerate dehydrogenase (NCBI) compare
b0945 pyrD -5.0 -13.1 dihydroorotate dehydrogenase (NCBI) compare
b0817 mntR -5.0 -3.5 DNA-binding transcriptional regulator of mntH (NCBI) compare
b1205 ychH -5.0 -1.0 predicted inner membrane protein (NCBI) compare
b2433 b2433 -4.9 -2.6 orf, hypothetical protein (VIMSS) compare
b0145 dksA -4.9 -2.4 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3958 argC -4.9 -8.6 N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) compare
b2279 nuoK -4.9 -1.5 NADH dehydrogenase subunit K (NCBI) compare
b1434 ydcN -4.9 -1.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b1942 fliJ -4.8 -1.0 flagellar biosynthesis chaperone (NCBI) compare
b1150 ymfR -4.8 -0.7 e14 prophage; predicted protein (NCBI) compare
b1183 umuD -4.8 -1.0 DNA polymerase V, subunit D (NCBI) compare
b1262 trpC -4.8 -5.4 N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) compare
b4699 fnrS -4.7 -0.7 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b0014 dnaK -4.7 -1.6 molecular chaperone DnaK (NCBI) compare
b3613 yibP -4.7 -7.0 putative membrane protein (VIMSS) compare
b2764 cysJ -4.7 -8.0 sulfite reductase, alpha subunit, flavoprotein (NCBI) compare
b3368 cysG -4.6 -12.3 fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) compare
b1550 b1550 -4.6 -1.0 orf, hypothetical protein (VIMSS) compare
b1062 pyrC -4.6 -8.2 dihydroorotase (NCBI) compare
b1524 yneH -4.5 -0.7 predicted glutaminase (NCBI) compare
b4603 rseX -4.5 -0.7 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b0073 leuB -4.5 -6.2 3-isopropylmalate dehydrogenase (VIMSS) compare
b2414 cysK -4.4 -6.4 cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) compare
b1293 sapB -4.3 -1.3 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1260 trpA -4.3 -2.5 tryptophan synthase subunit alpha (NCBI) compare
b3959 argB -4.3 -6.0 acetylglutamate kinase (RefSeq) compare
b1070 flgN -4.2 -0.9 export chaperone for FlgK and FlgL (NCBI) compare
b1361 ydaW -4.2 -0.6 orf, hypothetical protein (VIMSS) compare
b2479 gcvR -4.2 -6.7 transcriptional regulation of gcv operon (VIMSS) compare
b2023 hisH -4.2 -3.6 imidazole glycerol phosphate synthase subunit HisH (NCBI) compare
b2620 smpB -4.2 -1.2 SsrA-binding protein (NCBI) compare
b0683 fur -4.2 -1.1 ferric uptake regulator (NCBI) compare
b2501 ppk -4.2 -9.0 polyphosphate kinase (NCBI) compare
b1861 ruvA -4.1 -1.4 Holliday junction DNA helicase motor protein (NCBI) compare
b2939 yqgB -4.1 -0.8 predicted protein (RefSeq) compare
b2019 hisG -4.0 -2.9 ATP phosphoribosyltransferase (NCBI) compare
b4596 yciZ -4.0 -0.8 hypothetical protein (RefSeq) compare
b0741 pal -3.9 -4.6 peptidoglycan-associated outer membrane lipoprotein (NCBI) compare
b3839 tatC -3.9 -7.9 TatABCE protein translocation system subunit (NCBI) compare
b1291 sapD -3.9 -1.4 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2026 hisI -3.9 -3.6 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) compare
b2576 srmB -3.8 -4.1 ATP-dependent RNA helicase (NCBI) compare
b0439 lon -3.8 -7.3 DNA-binding ATP-dependent protease La (NCBI) compare
b3764 yifE -3.8 -3.7 hypothetical protein (NCBI) compare
b2599 pheA -3.8 -5.0 fused chorismate mutase P/prephenate dehydratase (NCBI) compare
b0627 tatE -3.7 -1.7 twin arginine translocase protein E (NCBI) compare
b1185 dsbB -3.7 -3.3 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2168 fruK -3.7 -0.9 1-phosphofructokinase (NCBI) compare
b1232 purU -3.6 -3.9 formyltetrahydrofolate deformylase (NCBI) compare
b4695 ykgT -3.6 -1.7 no description compare
b0912 ihfB -3.6 -2.2 integration host factor subunit beta (NCBI) compare
b1726 yniB -3.6 -0.9 predicted inner membrane protein (NCBI) compare
b4568 ytjA -3.6 -1.1 predicted protein (RefSeq) compare
b1882 cheY -3.5 -0.5 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3204 ptsN -3.5 -5.6 sugar-specific enzyme IIA component of PTS (NCBI) compare
b3500 gor -3.4 -1.4 glutathione reductase (NCBI) compare
b3026 qseC -3.4 -2.4 sensory histidine kinase in two-component regulatory system with QseB (NCBI) compare
b1600 mdtJ -3.4 -4.3 multidrug efflux system transporter (NCBI) compare
b2579 yfiD -3.3 -2.0 pyruvate formate lyase subunit (NCBI) compare
b2659 b2659 -3.3 -1.9 orf, hypothetical protein (VIMSS) compare
b1259 yciG -3.3 -0.8 orf, hypothetical protein (VIMSS) compare
b0300 ykgA -3.3 -2.2 putative ARAC-type regulatory protein (VIMSS) compare
b2080 b2080 -3.2 -1.1 orf, hypothetical protein (VIMSS) compare
b3190 yrbA -3.2 -3.0 orf, hypothetical protein (VIMSS) compare
b3008 metC -3.2 -5.1 cystathionine beta-lyase (NCBI) compare
b3935 priA -3.2 -2.2 primosome assembly protein PriA (NCBI) compare
b0232 yafN -3.1 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b4503 yafF -3.1 -0.7 no description compare
b3868 glnG -3.1 -4.4 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b0447 ybaO -3.1 -3.0 putative LRP-like transcriptional regulator (VIMSS) compare
b4146 yjeK -3.1 -2.0 predicted lysine aminomutase (NCBI) compare
b1286 rnb -3.1 -2.7 exoribonuclease II (NCBI) compare
b0142 folK -3.0 -0.4 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) compare
b2376 ypdI -3.0 -3.6 predicted lipoprotein involved in colanic acid biosynthesis (NCBI) compare
b4214 cysQ -3.0 -5.9 PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) compare
b4202 rpsR -3.0 -1.2 30S ribosomal protein S18 (NCBI) compare
b4520 ymgF -3.0 -1.1 hypothetical protein (NCBI) compare
b0200 gmhB -3.0 -1.2 hypothetical protein (NCBI) compare
b3790 rffC -2.9 -3.5 TDP-fucosamine acetyltransferase (RefSeq) compare
b3626 rfaJ -2.9 -9.5 UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase (NCBI) compare
b2049 cpsB -2.9 -2.8 mannose-1-phosphate guanyltransferase (NCBI) compare
b1712 ihfA -2.7 -1.0 integration host factor subunit alpha (NCBI) compare
b2476 purC -2.7 -1.9 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b1438 ydcQ -2.7 -1.9 predicted DNA-binding transcriptional regulator (RefSeq) compare
b4402 yjjY -2.7 -0.6 hypothetical protein (NCBI) compare
b0585 fes -2.7 -3.6 enterobactin/ferric enterobactin esterase (NCBI) compare
b1709 btuD -2.6 -0.5 vitamin B12-transporter ATPase (NCBI) compare
b2456 cchB -2.6 -1.9 predicted carboxysome structural protein, ethanolamine utilization protein (NCBI) compare
b3672 ivbL -2.6 -2.5 ilvB operon leader peptide (NCBI) compare
b3916 pfkA -2.6 -1.8 6-phosphofructokinase (NCBI) compare
b3164 pnp -2.5 -2.1 polynucleotide phosphorylase/polyadenylase (RefSeq) compare
b4411 ecnB -2.5 -1.3 entericidin B membrane lipoprotein (NCBI) compare
b0890 ftsK -2.5 -6.7 DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) compare
b2751 cysN -2.5 -4.4 sulfate adenylyltransferase subunit 1 (NCBI) compare
b0888 trxB -2.5 -2.6 thioredoxin reductase, FAD/NAD(P)-binding (NCBI) compare
b1290 sapF -2.5 -1.5 predicted antimicrobial peptide transporter subunit (NCBI) compare
b2699 recA -2.5 -1.2 recombinase A (NCBI) compare
b1125 potB -2.4 -2.3 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b1285 gmr -2.4 -3.1 modulator of Rnase II stability (NCBI) compare
b4541 yehK -2.4 -2.4 hypothetical protein (NCBI) compare
b0564 appY -2.4 -0.5 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b2340 sixA -2.4 -3.0 phosphohistidine phosphatase (NCBI) compare
b1620 malI -2.4 -1.9 DNA-binding transcriptional repressor (NCBI) compare
b2318 truA -2.3 -2.3 tRNA pseudouridine synthase A (NCBI) compare
b0803 ybiI -2.3 -1.4 hypothetical protein (NCBI) compare
b0798 ybiA -2.3 -1.4 hypothetical protein (NCBI) compare
b1692 ydiB -2.3 -2.5 quinate/shikimate 5-dehydrogenase, NAD(P)-binding (NCBI) compare
b2432 yfeY -2.2 -1.2 hypothetical protein (NCBI) compare
b2790 yqcA -2.2 -2.2 flavodoxin (NCBI) compare
b4650 yibS -2.2 -1.5 no description compare
b0630 lipB -2.2 -0.9 protein of lipoate biosynthesis (VIMSS) compare
b2498 upp -2.2 -2.3 uracil phosphoribosyltransferase (VIMSS) compare
b3619 rfaD -2.2 -3.6 ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) compare
b0592 fepB -2.1 -4.7 iron-enterobactin transporter subunit (NCBI) compare
b1332 ynaJ -2.1 -0.4 predicted inner membrane protein (NCBI) compare
b4184 yjfL -2.1 -5.4 conserved inner membrane protein (NCBI) compare
b2807 ygdD -2.1 -2.1 conserved inner membrane protein (NCBI) compare
b0460 hha -2.1 -2.7 modulator of gene expression, with H-NS (NCBI) compare
b4653 yicT -2.1 -1.9 no description compare
b0149 mrcB -2.1 -7.0 penicillin-binding protein 1b (NCBI) compare
b3290 trkA -2.1 -1.4 potassium transporter peripheral membrane component (NCBI) compare


Specific Phenotypes

For 3 genes in this experiment

For carbon source D-Mannose in Escherichia coli BW25113

For carbon source D-Mannose across organisms