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Experiment set3IT048 for
Methanococcus maripaludis JJ
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formate McAA riboflavin dropout
200 most detrimental genes:
gene
name
fitness
t score
description
MMJJ
_RS04415
+2.8
12.9
hypothetical protein
compare
MMJJ
_RS04005
+0.9
7.3
acetate--CoA ligase family protein
compare
MMJJ
_RS06505
+0.9
2.4
prephenate dehydratase
compare
MMJJ
_RS08130
+0.9
1.0
translation initiation factor IF-2 subunit gamma
compare
MMJJ
_RS03725
+0.8
2.1
sulfurtransferase TusA family protein
compare
MMJJ
_RS08935
+0.7
1.1
TIGR00288 family NYN domain-containing protein
compare
MMJJ
_RS07025
+0.7
3.3
tRNA (cytidine(56)-2'-O)-methyltransferase
compare
MMJJ
_RS04955
+0.7
4.2
tRNA pseudouridine(54/55) synthase Pus10
compare
MMJJ
_RS07005
+0.6
2.6
transcription factor S
compare
MMJJ
_RS03360
+0.6
1.1
hypothetical protein
compare
MMJJ
_RS06675
+0.6
4.5
TIGR01212 family radical SAM protein
compare
MMJJ
_RS07935
+0.6
0.6
protein fwdD
compare
MMJJ
_RS03410
+0.6
2.2
hypothetical protein
compare
MMJJ
_RS08830
+0.6
3.2
hypothetical protein
compare
MMJJ
_RS08870
+0.6
0.9
2-isopropylmalate synthase
compare
MMJJ
_RS06680
+0.6
3.5
DUF366 family protein
compare
MMJJ
_RS06275
+0.5
2.7
hypothetical protein
compare
MMJJ
_RS06735
+0.5
3.6
cobalt ECF transporter T component CbiQ
compare
MMJJ
_RS06515
+0.5
4.0
ribonuclease III
compare
MMJJ
_RS07235
+0.5
4.4
coenzyme F420 hydrogenase subunit alpha
compare
MMJJ
_RS06950
+0.5
3.5
4-demethylwyosine synthase TYW1
compare
MMJJ
_RS07920
+0.5
3.7
6-carboxytetrahydropterin synthase QueD
compare
MMJJ
_RS07010
+0.5
3.2
preprotein translocase subunit Sec61beta
compare
MMJJ
_RS09365
+0.5
1.6
hypothetical protein
compare
MMJJ
_RS04545
+0.5
1.6
PadR family transcriptional regulator
compare
MMJJ
_RS07225
+0.5
3.0
coenzyme F420 hydrogenase subunit gamma
compare
MMJJ
_RS06190
+0.5
3.6
7-cyano-7-deazaguanine synthase
compare
MMJJ
_RS06460
+0.5
3.0
cytochrome c
compare
MMJJ
_RS04105
+0.5
3.9
prepilin peptidase
compare
MMJJ
_RS06385
+0.5
2.1
hypothetical protein
compare
MMJJ
_RS03905
+0.5
2.4
ATP-binding cassette domain-containing protein
compare
MMJJ
_RS07220
+0.5
3.5
coenzyme F420 hydrogenase subunit beta
compare
MMJJ
_RS06440
+0.5
3.2
DUF4870 domain-containing protein
compare
MMJJ
_RS02125
+0.5
1.7
hypothetical protein
compare
MMJJ
_RS03605
+0.4
1.6
TIGR00297 family protein
compare
MMJJ
_RS06090
+0.4
2.4
hypothetical protein
compare
MMJJ
_RS07240
+0.4
3.8
MBL fold metallo-hydrolase
compare
MMJJ
_RS03775
+0.4
2.4
50S ribosomal protein L15e
compare
MMJJ
_RS06745
+0.4
2.6
energy-coupling factor ABC transporter permease
compare
MMJJ
_RS03250
+0.4
1.4
DUF2116 family Zn-ribbon domain-containing protein
compare
MMJJ
_RS06210
+0.4
2.0
hypothetical protein
compare
MMJJ
_RS05685
+0.4
2.4
class III signal peptide-containing protein
compare
MMJJ
_RS06500
+0.4
2.7
class I SAM-dependent methyltransferase
compare
MMJJ
_RS09145
+0.4
2.6
exodeoxyribonuclease III
compare
MMJJ
_RS00745
+0.4
1.5
hypothetical protein
compare
MMJJ
_RS07750
+0.4
1.3
class III signal peptide-containing protein
compare
MMJJ
_RS05040
+0.4
2.7
7-carboxy-7-deazaguanine synthase QueE
compare
MMJJ
_RS08515
+0.4
1.8
secondary thiamine-phosphate synthase enzyme YjbQ
compare
MMJJ
_RS04375
+0.4
1.6
hypothetical protein
compare
MMJJ
_RS07915
+0.4
2.1
CBS domain-containing protein
compare
MMJJ
_RS05975
+0.4
2.6
sulfurtransferase TusA family protein
compare
MMJJ
_RS06800
+0.4
1.9
prefoldin subunit alpha
compare
MMJJ
_RS05580
+0.4
2.1
methanogenesis marker 9 domain-containing protein
compare
MMJJ
_RS05915
+0.4
1.1
multiprotein bridging factor aMBF1
compare
MMJJ
_RS06580
+0.4
2.5
alanine dehydrogenase
compare
MMJJ
_RS05695
+0.4
1.3
class III signal peptide-containing protein
compare
MMJJ
_RS07445
+0.4
2.4
RlmF-related methyltransferase
compare
MMJJ
_RS06685
+0.4
3.0
S-layer protein
compare
MMJJ
_RS06205
+0.4
2.4
EamA family transporter
compare
MMJJ
_RS07210
+0.4
2.4
AmmeMemoRadiSam system protein B
compare
MMJJ
_RS09405
+0.3
1.4
hypothetical protein
compare
MMJJ
_RS06470
+0.3
2.4
tripartite tricarboxylate transporter permease
compare
MMJJ
_RS06810
+0.3
2.7
L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha
compare
MMJJ
_RS07820
+0.3
2.7
bifunctional hexulose-6-phosphate synthase/ribonuclease regulator
compare
MMJJ
_RS06045
+0.3
2.4
hypothetical protein
compare
MMJJ
_RS04215
+0.3
2.9
DMT family transporter
compare
MMJJ
_RS05400
+0.3
1.6
CoA-binding protein
compare
MMJJ
_RS01855
+0.3
2.6
MBL fold metallo-hydrolase
compare
MMJJ
_RS08305
+0.3
2.0
peroxiredoxin
compare
MMJJ
_RS09050
+0.3
1.8
hypothetical protein
compare
MMJJ
_RS07985
+0.3
1.6
hypothetical protein
compare
MMJJ
_RS06770
+0.3
2.7
hypothetical protein
compare
MMJJ
_RS06585
+0.3
2.2
alanine racemase
compare
MMJJ
_RS06710
+0.3
2.6
TldD/PmbA family protein
compare
MMJJ
_RS07260
+0.3
2.2
PspC domain-containing protein
compare
MMJJ
_RS06055
+0.3
2.4
S-methyl-5-thioribose-1-phosphate isomerase
compare
MMJJ
_RS07450
+0.3
2.3
hypothetical protein
compare
MMJJ
_RS03205
+0.3
1.7
metallophosphoesterase
compare
MMJJ
_RS05335
+0.3
1.9
heavy metal-binding domain-containing protein
compare
MMJJ
_RS06740
+0.3
2.1
energy-coupling factor ABC transporter substrate-binding protein
compare
MMJJ
_RS08225
+0.3
1.4
peptidylprolyl isomerase
compare
MMJJ
_RS07280
+0.3
1.7
phosphomannomutase/phosphoglucomutase
compare
MMJJ
_RS09325
+0.3
1.9
hypothetical protein
compare
MMJJ
_RS03805
+0.3
0.8
hypothetical protein
compare
MMJJ
_RS06640
+0.3
2.1
YfcE family phosphodiesterase
compare
MMJJ
_RS06280
+0.3
2.3
hypothetical protein
compare
MMJJ
_RS08525
+0.3
1.5
peptidylprolyl isomerase
compare
MMJJ
_RS09295
+0.3
0.4
hypothetical protein
compare
MMJJ
_RS07800
+0.3
2.4
AMP-binding protein
compare
MMJJ
_RS07230
+0.3
2.0
coenzyme F420-reducing hydrogenase, FrhD protein
compare
MMJJ
_RS00090
+0.3
2.1
4Fe-4S binding protein
compare
MMJJ
_RS02270
+0.3
1.8
HEPN domain-containing protein
compare
MMJJ
_RS01140
+0.3
1.2
helix-turn-helix domain-containing protein
compare
MMJJ
_RS06535
+0.3
2.4
UPF0104 family protein
compare
MMJJ
_RS01530
+0.3
0.9
YwbE family protein
compare
MMJJ
_RS08285
+0.3
2.1
class I SAM-dependent methyltransferase
compare
MMJJ
_RS07270
+0.3
2.2
ribonuclease HII
compare
MMJJ
_RS01010
+0.3
2.7
right-handed parallel beta-helix repeat-containing protein
compare
MMJJ
_RS07795
+0.3
1.8
cupin domain-containing protein
compare
MMJJ
_RS09230
+0.3
1.2
hypothetical protein
compare
MMJJ
_RS03375
+0.3
1.3
hypothetical protein
compare
MMJJ
_RS07890
+0.3
1.7
pyrimidine dimer DNA glycosylase/endonuclease V
compare
MMJJ
_RS07200
+0.3
2.1
MFS transporter
compare
MMJJ
_RS05410
+0.3
1.6
RecB-family nuclease
compare
MMJJ
_RS00150
+0.3
1.3
DUF2180 family protein
compare
MMJJ
_RS05235
+0.3
2.3
Flp pilus assembly complex ATPase component TadA
compare
MMJJ
_RS09300
+0.3
0.7
hypothetical protein
compare
MMJJ
_RS08100
+0.3
1.5
hypothetical protein
compare
MMJJ
_RS01790
+0.3
2.1
pyridoxamine 5'-phosphate oxidase family protein
compare
MMJJ
_RS04345
+0.3
1.3
DUF2080 family transposase-associated protein
compare
MMJJ
_RS05900
+0.3
2.0
ATP-binding cassette domain-containing protein
compare
MMJJ
_RS00335
+0.3
1.2
chemotaxis protein CheW
compare
MMJJ
_RS07815
+0.3
1.8
2-oxoacid:acceptor oxidoreductase family protein
compare
MMJJ
_RS06590
+0.3
1.9
sodium:alanine symporter family protein
compare
MMJJ
_RS07825
+0.3
1.2
YciI family protein
compare
MMJJ
_RS05605
+0.2
1.1
hypothetical protein
compare
MMJJ
_RS07480
+0.2
2.0
FAD-dependent oxidoreductase
compare
MMJJ
_RS01795
+0.2
1.7
TIGR00266 family protein
compare
MMJJ
_RS05500
+0.2
2.2
hypothetical protein
compare
MMJJ
_RS06765
+0.2
2.0
hypothetical protein
compare
MMJJ
_RS04610
+0.2
1.2
ribosome assembly RNA-binding protein YhbY
compare
MMJJ
_RS03835
+0.2
0.7
DUF504 domain-containing protein
compare
MMJJ
_RS04850
+0.2
1.4
energy-coupling factor transporter transmembrane protein EcfT
compare
MMJJ
_RS07185
+0.2
0.9
DUF371 domain-containing protein
compare
MMJJ
_RS06100
+0.2
1.6
rubrerythrin
compare
MMJJ
_RS07810
+0.2
1.6
3-methyl-2-oxobutanoate dehydrogenase subunit VorB
compare
MMJJ
_RS01300
+0.2
1.6
MarR family transcriptional regulator
compare
MMJJ
_RS08685
+0.2
1.8
phosphate ABC transporter permease subunit PstC
compare
MMJJ
_RS07215
+0.2
1.9
TIGR00341 family protein
compare
MMJJ
_RS06960
+0.2
2.0
CAP domain-containing protein
compare
MMJJ
_RS06235
+0.2
1.9
IGHMBP2 family helicase
compare
MMJJ
_RS08470
+0.2
0.9
ferredoxin family protein
compare
MMJJ
_RS05965
+0.2
1.9
MFS transporter
compare
MMJJ
_RS05690
+0.2
2.1
hypothetical protein
compare
MMJJ
_RS07885
+0.2
1.7
NERD domain-containing protein
compare
MMJJ
_RS06495
+0.2
0.8
hypothetical protein
compare
MMJJ
_RS07385
+0.2
1.7
ribosomal protein S18-alanine N-acetyltransferase
compare
MMJJ
_RS05520
+0.2
1.8
H(2)-dependent methylenetetrahydromethanopterin dehydrogenase-related protein
compare
MMJJ
_RS07760
+0.2
1.3
GNAT family N-acetyltransferase
compare
MMJJ
_RS05385
+0.2
1.6
hypothetical protein
compare
MMJJ
_RS08165
+0.2
1.2
thermonuclease family protein
compare
MMJJ
_RS07205
+0.2
1.3
MTH895/ArsE family thioredoxin-like protein
compare
MMJJ
_RS06120
+0.2
1.5
DUF4013 domain-containing protein
compare
MMJJ
_RS06455
+0.2
1.7
YeeE/YedE family protein
compare
MMJJ
_RS06445
+0.2
1.9
hypothetical protein
compare
MMJJ
_RS08350
+0.2
1.9
heavy metal translocating P-type ATPase
compare
MMJJ
_RS06085
+0.2
1.1
proteasome assembly chaperone family protein
compare
MMJJ
_RS01955
+0.2
1.7
hypothetical protein
compare
MMJJ
_RS07365
+0.2
1.5
CatB-related O-acetyltransferase
compare
MMJJ
_RS02230
+0.2
1.7
hypothetical protein
compare
MMJJ
_RS05585
+0.2
1.6
hypothetical protein
compare
MMJJ
_RS05390
+0.2
1.7
tRNA pseudouridine(13) synthase TruD
compare
MMJJ
_RS04390
+0.2
1.6
rhomboid family intramembrane serine protease
compare
MMJJ
_RS02160
+0.2
1.2
amino acid ABC transporter permease
compare
MMJJ
_RS07695
+0.2
1.7
glycoside hydrolase family 15 protein
compare
MMJJ
_RS05700
+0.2
1.4
metallophosphoesterase
compare
MMJJ
_RS05715
+0.2
1.5
phosphoadenosine phosphosulfate reductase family protein
compare
MMJJ
_RS01670
+0.2
1.0
hypothetical protein
compare
MMJJ
_RS00145
+0.2
1.5
aquaporin family protein
compare
MMJJ
_RS03515
+0.2
1.1
GPR1/FUN34/YaaH family transporter
compare
MMJJ
_RS08270
+0.2
1.7
iron ABC transporter substrate-binding protein
compare
MMJJ
_RS05835
+0.2
1.7
bis-aminopropyl spermidine synthase family protein
compare
MMJJ
_RS06290
+0.2
1.2
DUF749 domain-containing protein
compare
MMJJ
_RS06550
+0.2
1.5
ABC transporter permease
compare
MMJJ
_RS09015
+0.2
1.4
SPFH domain-containing protein
compare
MMJJ
_RS08160
+0.2
1.2
tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO
compare
MMJJ
_RS00900
+0.2
0.9
PC4/YdbC family ssDNA-binding protein
compare
MMJJ
_RS05960
+0.2
1.3
DUF169 domain-containing protein
compare
MMJJ
_RS07860
+0.2
1.0
hypothetical protein
compare
MMJJ
_RS05090
+0.2
0.9
MGMT family protein
compare
MMJJ
_RS03450
+0.2
1.1
hypothetical protein
compare
MMJJ
_RS01430
+0.2
1.3
hypothetical protein
compare
MMJJ
_RS09005
+0.2
1.6
N-6 DNA methylase
compare
MMJJ
_RS02180
+0.2
1.0
DHH family phosphoesterase
compare
MMJJ
_RS07610
+0.2
1.0
DUF2119 domain-containing protein
compare
MMJJ
_RS02165
+0.2
1.2
ABC transporter substrate-binding protein
compare
MMJJ
_RS08485
+0.2
0.9
Lrp/AsnC family transcriptional regulator
compare
MMJJ
_RS09360
+0.2
1.2
hypothetical protein
compare
MMJJ
_RS02895
+0.2
1.2
ATP-binding protein
compare
MMJJ
_RS05525
+0.2
1.1
GTP-binding protein
compare
MMJJ
_RS07255
+0.2
1.6
hypothetical protein
compare
MMJJ
_RS05980
+0.2
1.1
DUF5400 domain-containing protein
compare
MMJJ
_RS05355
+0.2
1.1
DUF2121 domain-containing protein
compare
MMJJ
_RS09330
+0.2
0.9
hypothetical protein
compare
MMJJ
_RS09390
+0.2
0.7
hypothetical protein
compare
MMJJ
_RS08030
+0.2
1.1
hypothetical protein
compare
MMJJ
_RS07905
+0.2
1.2
DUF89 domain-containing protein
compare
MMJJ
_RS05200
+0.2
1.3
TIGR04013 family B12-binding domain/radical SAM domain-containing protein
compare
MMJJ
_RS07830
+0.2
1.2
DUF1786 domain-containing protein
compare
MMJJ
_RS06790
+0.2
1.4
nucleotidyltransferase family protein
compare
MMJJ
_RS09065
+0.2
0.8
hypothetical protein
compare
MMJJ
_RS02965
+0.2
0.9
RimK-like ATPgrasp N-terminal domain-containing protein
compare
MMJJ
_RS05510
+0.2
1.1
archaellum operon transcriptional activator EarA family protein
compare
MMJJ
_RS04635
+0.2
0.7
DUF367 family protein
compare
MMJJ
_RS08745
+0.2
1.3
glycosyltransferase family 9 protein
compare
MMJJ
_RS03755
+0.2
0.9
hypothetical protein
compare
MMJJ
_RS06105
+0.2
1.1
DUF99 family protein
compare
MMJJ
_RS03290
+0.2
1.3
amidohydrolase
compare
MMJJ
_RS06555
+0.2
1.2
ATP-binding cassette domain-containing protein
compare
MMJJ
_RS08045
+0.2
1.2
transporter substrate-binding domain-containing protein
compare
Specific Phenotypes
None in this experiment
For Methanococcus maripaludis JJ in nutrient t1 experiments