| | gene | name | fitness | t score | description | |
|---|
| b1260 | trpA | -9.2 | -6.3 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0523 | purE | -7.2 | -5.0 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b0907 | serC | -6.7 | -10.3 | phosphoserine aminotransferase (NCBI) | compare |
| b3941 | metF | -6.4 | -13.6 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b2913 | serA | -6.3 | -4.3 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b1261 | trpB | -6.2 | -4.2 | tryptophan synthase subunit beta (NCBI) | compare |
| b4388 | serB | -6.0 | -9.9 | 3-phosphoserine phosphatase (NCBI) | compare |
| b1192 | ldcA | -6.0 | -4.1 | L,D-carboxypeptidase A (NCBI) | compare |
| b2020 | hisD | -5.9 | -10.6 | histidinol dehydrogenase (NCBI) | compare |
| b2022 | hisB | -5.8 | -11.2 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b2021 | hisC | -5.7 | -3.9 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b3829 | metE | -5.7 | -20.9 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (NCBI) | compare |
| b2476 | purC | -5.6 | -3.6 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b3770 | ilvE | -5.6 | -12.0 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b2024 | hisA | -5.6 | -3.2 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b3771 | ilvD | -5.4 | -14.3 | dihydroxy-acid dehydratase (NCBI) | compare |
| b3389 | aroB | -5.3 | -17.7 | 3-dehydroquinate synthase (NCBI) | compare |
| b3172 | argG | -5.3 | -14.9 | argininosuccinate synthase (NCBI) | compare |
| b3281 | aroE | -5.3 | -21.8 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b4006 | purH | -5.3 | -14.5 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2025 | hisF | -5.3 | -6.3 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b1693 | aroD | -5.3 | -11.7 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0423 | thiI | -5.2 | -8.0 | thiamine biosynthesis protein ThiI (NCBI) | compare |
| b0004 | thrC | -5.2 | -9.9 | threonine synthase (NCBI) | compare |
| b2312 | purF | -5.2 | -9.6 | amidophosphoribosyltransferase (NCBI) | compare |
| b0242 | proB | -5.1 | -8.5 | gamma-glutamyl kinase (NCBI) | compare |
| b0243 | proA | -5.1 | -11.9 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2329 | aroC | -5.1 | -6.0 | chorismate synthase (NCBI) | compare |
| b3774 | ilvC | -5.0 | -19.5 | ketol-acid reductoisomerase (NCBI) | compare |
| b0386 | proC | -5.0 | -10.2 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b2557 | purL | -5.0 | -11.6 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b2023 | hisH | -5.0 | -7.6 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b4005 | purD | -4.9 | -12.3 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b0145 | dksA | -4.9 | -3.4 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b0522 | purK | -4.9 | -8.8 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b1062 | pyrC | -4.9 | -10.9 | dihydroorotase (NCBI) | compare |
| b0908 | aroA | -4.9 | -10.4 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b3828 | metR | -4.8 | -12.4 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b2026 | hisI | -4.7 | -12.2 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b3960 | argH | -4.7 | -13.8 | argininosuccinate lyase (NCBI) | compare |
| b0033 | carB | -4.6 | -20.1 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2499 | purM | -4.5 | -8.0 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0003 | thrB | -4.5 | -9.5 | homoserine kinase (NCBI) | compare |
| b2414 | cysK | -4.4 | -13.0 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b0585 | fes | -4.3 | -9.1 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b4054 | tyrB | -4.3 | -14.4 | tyrosine aminotransferase, tyrosine-repressible, PLP-dependent (NCBI) | compare |
| b4214 | cysQ | -4.2 | -17.5 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b2019 | hisG | -4.1 | -4.5 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0032 | carA | -4.1 | -9.0 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b2838 | lysA | -4.0 | -15.7 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b3642 | pyrE | -4.0 | -4.8 | orotate phosphoribosyltransferase (NCBI) | compare |
| b2600 | tyrA | -4.0 | -9.7 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b3204 | ptsN | -3.9 | -9.2 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0928 | aspC | -3.9 | -11.6 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0945 | pyrD | -3.8 | -15.3 | dihydroorotate dehydrogenase (NCBI) | compare |
| b4245 | pyrB | -3.8 | -15.0 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2762 | cysH | -3.7 | -11.1 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0078 | ilvH | -3.7 | -12.8 | acetolactate synthase small subunit (NCBI) | compare |
| b0118 | acnB | -3.7 | -5.0 | aconitate hydratase (NCBI) | compare |
| b0002 | thrA | -3.7 | -16.0 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2501 | ppk | -3.7 | -15.1 | polyphosphate kinase (NCBI) | compare |
| b0049 | apaH | -3.6 | -8.4 | diadenosinetetraphosphatase (NCBI) | compare |
| b2764 | cysJ | -3.6 | -13.4 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b0439 | lon | -3.6 | -7.6 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3916 | pfkA | -3.6 | -4.9 | 6-phosphofructokinase (NCBI) | compare |
| b2763 | cysI | -3.6 | -13.5 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b1281 | pyrF | -3.5 | -3.4 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b0077 | ilvI | -3.5 | -14.9 | acetolactate synthase III large subunit (NCBI) | compare |
| b3956 | ppc | -3.4 | -20.7 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b0142 | folK | -3.4 | -1.4 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b2320 | pdxB | -3.4 | -12.4 | erythronate-4-phosphate dehydrogenase (NCBI) | compare |
| b3414 | gntY | -3.3 | -9.1 | predicted gluconate transport associated protein (NCBI) | compare |
| b2564 | pdxJ | -3.3 | -6.7 | pyridoxal phosphate biosynthetic protein (NCBI) | compare |
| b1865 | nudB | -3.3 | -2.7 | dATP pyrophosphohydrolase (NCBI) | compare |
| b0590 | fepD | -3.3 | -9.9 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2750 | cysC | -3.3 | -9.2 | adenylylsulfate kinase (NCBI) | compare |
| b3741 | gidA | -3.2 | -11.7 | glucose-inhibited division protein A (NCBI) | compare |
| b3993 | thiE | -3.2 | -10.5 | thiamine-phosphate pyrophosphorylase (NCBI) | compare |
| b3870 | glnA | -3.2 | -3.1 | glutamine synthetase (NCBI) | compare |
| b0588 | fepC | -3.2 | -11.6 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3959 | argB | -3.2 | -13.2 | acetylglutamate kinase (RefSeq) | compare |
| b3169 | nusA | -3.1 | -6.1 | transcription elongation factor NusA (NCBI) | compare |
| b0592 | fepB | -3.1 | -12.5 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2818 | argA | -3.1 | -11.6 | N-acetylglutamate synthase (NCBI) | compare |
| b0589 | fepG | -3.1 | -10.6 | iron-enterobactin transporter subunit (NCBI) | compare |
| b3992 | thiF | -3.1 | -12.9 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3991 | thiG | -3.1 | -12.0 | thiamin biosynthesis, thiazole moiety (VIMSS) | compare |
| b3958 | argC | -3.0 | -15.8 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b2103 | thiD | -3.0 | -9.6 | phosphomethylpyrimidine kinase (NCBI) | compare |
| b3368 | cysG | -2.9 | -16.6 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b3052 | rfaE | -2.9 | -9.6 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b3772 | ilvA | -2.9 | -16.1 | threonine dehydratase (NCBI) | compare |
| b3008 | metC | -2.9 | -14.3 | cystathionine beta-lyase (NCBI) | compare |
| b3957 | argE | -2.9 | -14.0 | acetylornithine deacetylase (NCBI) | compare |
| b3990 | thiH | -2.9 | -11.9 | thiamine biosynthesis protein ThiH (NCBI) | compare |
| b4177 | purA | -2.9 | -2.8 | adenylosuccinate synthetase (NCBI) | compare |
| b0113 | pdhR | -2.8 | -4.2 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b0052 | pdxA | -2.7 | -11.6 | 4-hydroxythreonine-4-phosphate dehydrogenase (NCBI) | compare |
| b1860 | ruvB | -2.7 | -3.6 | Holliday junction DNA helicase B (NCBI) | compare |
| b2784 | relA | -2.7 | -11.4 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b3811 | xerC | -2.7 | -5.4 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b3621 | rfaC | -2.7 | -8.6 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b1262 | trpC | -2.6 | -5.1 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b3290 | trkA | -2.6 | -5.8 | potassium transporter peripheral membrane component (NCBI) | compare |
| b0437 | clpP | -2.6 | -12.2 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b3706 | trmE | -2.6 | -9.7 | tRNA modification GTPase (NCBI) | compare |
| b0750 | nadA | -2.6 | -5.2 | quinolinate synthetase (NCBI) | compare |
| b2894 | xerD | -2.6 | -3.0 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3619 | rfaD | -2.5 | -7.6 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b2599 | pheA | -2.5 | -6.8 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b3994 | thiC | -2.4 | -13.5 | thiamine biosynthesis protein ThiC (NCBI) | compare |
| b2830 | nudH | -2.4 | -3.6 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b2820 | recB | -2.4 | -3.6 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b1685 | ydiH | -2.4 | -0.9 | predicted protein (RefSeq) | compare |
| b2752 | cysD | -2.4 | -8.3 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b2751 | cysN | -2.3 | -11.1 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b1084 | rne | -2.3 | -7.5 | fused ribonucleaseE: endoribonuclease/RNA-binding protein/RNA degradosome binding protein (NCBI) | compare |
| b0890 | ftsK | -2.3 | -10.3 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b3483 | yhhH | -2.3 | -2.8 | orf, hypothetical protein (VIMSS) | compare |
| b2029 | gnd | -2.3 | -11.1 | 6-phosphogluconate dehydrogenase (NCBI) | compare |
| b3387 | dam | -2.3 | -15.1 | DNA adenine methylase (NCBI) | compare |
| b0889 | lrp | -2.3 | -3.7 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b2500 | purN | -2.2 | -6.3 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b2839 | lysR | -2.2 | -7.0 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b3725 | pstB | -2.2 | -4.6 | phosphate transporter subunit (NCBI) | compare |
| b1273 | yciN | -2.2 | -3.0 | hypothetical protein (NCBI) | compare |
| b4407 | thiS | -2.2 | -2.0 | sulfur carrier protein ThiS (NCBI) | compare |
| b0726 | sucA | -2.2 | -4.9 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b3939 | metB | -2.1 | -12.2 | cystathionine gamma-synthase (NCBI) | compare |
| b0073 | leuB | -2.1 | -10.9 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b4171 | miaA | -2.1 | -9.2 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b3620 | rfaF | -2.1 | -6.1 | ADP-heptose:LPS heptosyltransferase II (NCBI) | compare |
| b0222 | lpcA | -2.0 | -3.3 | phosphoheptose isomerase (NCBI) | compare |
| b2528 | iscA | -2.0 | -3.2 | iron-sulfur cluster assembly protein (NCBI) | compare |
| b3650 | spoT | -2.0 | -6.3 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b3849 | trkH | -1.9 | -12.7 | potassium transporter (NCBI) | compare |
| b4025 | pgi | -1.9 | -10.5 | glucose-6-phosphate isomerase (NCBI) | compare |
| b0200 | gmhB | -1.9 | -3.1 | hypothetical protein (NCBI) | compare |
| b3844 | fre | -1.9 | -7.5 | NAD(P)H-flavin reductase (NCBI) | compare |
| b4246 | pyrL | -1.9 | -2.2 | pyrBI operon leader peptide (NCBI) | compare |
| b1630 | rsxD | -1.9 | -7.5 | electron transport complex protein RnfD (NCBI) | compare |
| b0683 | fur | -1.8 | -1.9 | ferric uptake regulator (NCBI) | compare |
| b2188 | yejM | -1.8 | -9.1 | predicted hydrolase, inner membrane (NCBI) | compare |
| b3386 | rpe | -1.8 | -2.4 | ribulose-phosphate 3-epimerase (NCBI) | compare |
| b3390 | aroK | -1.8 | -4.0 | shikimate kinase I (NCBI) | compare |
| b1628 | rsxB | -1.8 | -4.8 | electron transport complex protein RnfB (NCBI) | compare |
| b0074 | leuA | -1.8 | -10.9 | 2-isopropylmalate synthase (NCBI) | compare |
| b1263 | trpD | -1.8 | -2.1 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b1712 | ihfA | -1.8 | -3.3 | integration host factor subunit alpha (NCBI) | compare |
| b0071 | leuD | -1.7 | -7.7 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b1291 | sapD | -1.7 | -3.3 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b1863 | ruvC | -1.7 | -4.6 | Holliday junction resolvase (NCBI) | compare |
| b3671 | ilvB | -1.7 | -11.0 | acetolactate synthase large subunit (NCBI) | compare |
| b2423 | cysW | -1.7 | -5.3 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2424 | cysU | -1.6 | -3.4 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1292 | sapC | -1.6 | -2.9 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b1857 | yebL | -1.6 | -7.0 | putative adhesin (VIMSS) | compare |
| b0072 | leuC | -1.6 | -10.0 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b2422 | cysA | -1.5 | -7.9 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b2822 | recC | -1.5 | -7.2 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b1426 | ydcH | -1.5 | -1.7 | orf, hypothetical protein (VIMSS) | compare |
| b3672 | ivbL | -1.5 | -5.9 | ilvB operon leader peptide (NCBI) | compare |
| b0658 | ybeX | -1.5 | -8.7 | predicteed ion transport (NCBI) | compare |
| b2935 | tktA | -1.5 | -4.3 | transketolase 1, thiamin-binding (NCBI) | compare |
| b1627 | rsxA | -1.4 | -6.3 | Na(+)-translocating NADH-quinone reductase subunit E (NCBI) | compare |
| b2618 | b2618 | -1.4 | -2.7 | orf, hypothetical protein (VIMSS) | compare |
| b3769 | ilvM | -1.4 | -2.6 | acetolactate synthase II, small subunit (NCBI) | compare |
| b1859 | znuB | -1.4 | -6.3 | high-affinity zinc transporter membrane component (NCBI) | compare |
| b2683 | ygaH | -1.4 | -5.3 | predicted inner membrane protein (NCBI) | compare |
| b3766 | ilvL | -1.4 | -3.7 | ilvG operon leader peptide (NCBI) | compare |
| b0109 | nadC | -1.3 | -7.5 | nicotinate-nucleotide pyrophosphorylase (NCBI) | compare |
| b0542 | renD | -1.3 | -2.2 | orf, hypothetical protein (VIMSS) | compare |
| b0053 | surA | -1.3 | -5.6 | peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) | compare |
| b4480 | hdfR | -1.3 | -5.9 | transcriptional regulator HdfR (NCBI) | compare |
| b3121 | yhaC | -1.3 | -2.2 | hypothetical protein (NCBI) | compare |
| b2214 | yojL | -1.3 | -6.5 | predicted thiamine biosynthesis lipoprotein (NCBI) | compare |
| b2574 | nadB | -1.3 | -7.4 | L-aspartate oxidase (NCBI) | compare |
| b3652 | recG | -1.3 | -9.1 | ATP-dependent DNA helicase (NCBI) | compare |
| b0500 | ybbD | -1.3 | -1.4 | hypothetical protein (RefSeq) | compare |
| b3609 | secB | -1.3 | -3.7 | export protein SecB (NCBI) | compare |
| b2236 | yfaE | -1.3 | -4.6 | predicted 2Fe-2S cluster-containing protein (NCBI) | compare |
| b1632 | rsxE | -1.3 | -7.0 | NADH-ubiquinone oxidoreductase (NCBI) | compare |
| b3773 | ilvY | -1.3 | -7.9 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2340 | sixA | -1.2 | -3.6 | phosphohistidine phosphatase (NCBI) | compare |
| b3359 | argD | -1.2 | -9.9 | bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase (NCBI) | compare |
| b1858 | znuC | -1.2 | -4.8 | high-affinity zinc transporter ATPase (NCBI) | compare |
| b0737 | tolQ | -1.2 | -3.7 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3649 | rpoZ | -1.2 | -2.5 | DNA-directed RNA polymerase subunit omega (NCBI) | compare |
| b4013 | metA | -1.2 | -4.2 | homoserine O-succinyltransferase (NCBI) | compare |
| b2684 | mprA | -1.2 | -3.4 | DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) | compare |
| b1533 | ydeD | -1.2 | -2.7 | orf, hypothetical protein (VIMSS) | compare |
| b1545 | pinQ | -1.2 | -2.0 | Qin prophage; predicted site-specific recombinase (NCBI) | compare |
| b0912 | ihfB | -1.2 | -4.2 | integration host factor subunit beta (NCBI) | compare |
| b3778 | rep | -1.1 | -7.9 | DNA helicase and single-stranded DNA-dependent ATPase (NCBI) | compare |
| b3630 | rfaP | -1.1 | -8.6 | kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) | compare |
| b1251 | yciI | -1.1 | -3.2 | orf, hypothetical protein (VIMSS) | compare |
| b4243 | yjgF | -1.1 | -5.1 | orf, hypothetical protein (VIMSS) | compare |
| b1861 | ruvA | -1.1 | -2.2 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b3005 | exbD | -1.1 | -5.2 | membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) | compare |
| b1290 | sapF | -1.1 | -2.7 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |