| | gene | name | fitness | t score | description | |
|---|
| b2838 | lysA | -8.5 | -15.3 | diaminopimelate decarboxylase, PLP-binding (NCBI) | compare |
| b0004 | thrC | -7.6 | -15.5 | threonine synthase (NCBI) | compare |
| b0071 | leuD | -7.5 | -12.3 | isopropylmalate isomerase small subunit (NCBI) | compare |
| b1261 | trpB | -7.3 | -4.7 | tryptophan synthase subunit beta (NCBI) | compare |
| b3774 | ilvC | -6.8 | -26.4 | ketol-acid reductoisomerase (NCBI) | compare |
| b3281 | aroE | -6.6 | -24.5 | dehydroshikimate reductase, NAD(P)-binding (NCBI) | compare |
| b0908 | aroA | -6.6 | -17.5 | 3-phosphoshikimate 1-carboxyvinyltransferase (NCBI) | compare |
| b2784 | relA | -6.5 | -17.4 | (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) | compare |
| b0073 | leuB | -6.5 | -15.8 | 3-isopropylmalate dehydrogenase (VIMSS) | compare |
| b3771 | ilvD | -6.2 | -21.9 | dihydroxy-acid dehydratase (NCBI) | compare |
| b0074 | leuA | -6.1 | -14.7 | 2-isopropylmalate synthase (NCBI) | compare |
| b0386 | proC | -6.0 | -11.5 | pyrroline-5-carboxylate reductase (NCBI) | compare |
| b0523 | purE | -6.0 | -7.9 | phosphoribosylaminoimidazole carboxylase catalytic subunit (NCBI) | compare |
| b2188 | yejM | -5.9 | -13.9 | predicted hydrolase, inner membrane (NCBI) | compare |
| b2025 | hisF | -5.9 | -8.5 | imidazole glycerol phosphate synthase subunit HisF (NCBI) | compare |
| b3389 | aroB | -5.7 | -20.6 | 3-dehydroquinate synthase (NCBI) | compare |
| b3770 | ilvE | -5.7 | -17.4 | branched-chain amino acid aminotransferase (NCBI) | compare |
| b0072 | leuC | -5.7 | -17.5 | isopropylmalate isomerase large subunit (NCBI) | compare |
| b4005 | purD | -5.7 | -15.2 | phosphoribosylamine--glycine ligase (NCBI) | compare |
| b2499 | purM | -5.6 | -8.7 | phosphoribosylaminoimidazole synthetase (NCBI) | compare |
| b0907 | serC | -5.6 | -8.7 | phosphoserine aminotransferase (NCBI) | compare |
| b2476 | purC | -5.5 | -4.1 | phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) | compare |
| b1260 | trpA | -5.4 | -5.5 | tryptophan synthase subunit alpha (NCBI) | compare |
| b0242 | proB | -5.4 | -9.5 | gamma-glutamyl kinase (NCBI) | compare |
| b1693 | aroD | -5.4 | -15.0 | 3-dehydroquinate dehydratase (NCBI) | compare |
| b0243 | proA | -5.3 | -14.8 | gamma-glutamyl phosphate reductase (NCBI) | compare |
| b2913 | serA | -5.3 | -13.8 | D-3-phosphoglycerate dehydrogenase (NCBI) | compare |
| b4006 | purH | -5.2 | -20.4 | bifunctionalphosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (NCBI) | compare |
| b2329 | aroC | -5.2 | -12.3 | chorismate synthase (NCBI) | compare |
| b0145 | dksA | -5.1 | -4.9 | DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) | compare |
| b2557 | purL | -5.0 | -18.9 | phosphoribosylformylglycinamidine synthase (NCBI) | compare |
| b0522 | purK | -5.0 | -12.7 | phosphoribosylaminoimidazole carboxylase (NCBI) | compare |
| b4388 | serB | -4.9 | -9.1 | 3-phosphoserine phosphatase (NCBI) | compare |
| b3772 | ilvA | -4.9 | -18.2 | threonine dehydratase (NCBI) | compare |
| b2600 | tyrA | -4.8 | -9.4 | fused chorismate mutase T/prephenate dehydrogenase (NCBI) | compare |
| b3941 | metF | -4.7 | -15.9 | 5,10-methylenetetrahydrofolate reductase (NCBI) | compare |
| b0002 | thrA | -4.7 | -22.8 | bifunctional aspartokinase I/homeserine dehydrogenase I (NCBI) | compare |
| b2023 | hisH | -4.7 | -9.1 | imidazole glycerol phosphate synthase subunit HisH (NCBI) | compare |
| b2312 | purF | -4.7 | -11.0 | amidophosphoribosyltransferase (NCBI) | compare |
| b0003 | thrB | -4.6 | -10.7 | homoserine kinase (NCBI) | compare |
| b2022 | hisB | -4.5 | -12.9 | imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase (VIMSS) | compare |
| b3960 | argH | -4.4 | -16.5 | argininosuccinate lyase (NCBI) | compare |
| b1192 | ldcA | -4.4 | -10.0 | L,D-carboxypeptidase A (NCBI) | compare |
| b3956 | ppc | -4.4 | -25.5 | phosphoenolpyruvate carboxylase (NCBI) | compare |
| b2020 | hisD | -4.4 | -12.6 | histidinol dehydrogenase (NCBI) | compare |
| b1263 | trpD | -4.3 | -4.3 | bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) | compare |
| b3939 | metB | -4.3 | -20.7 | cystathionine gamma-synthase (NCBI) | compare |
| b0033 | carB | -4.3 | -23.7 | carbamoyl-phosphate synthase large subunit (NCBI) | compare |
| b2021 | hisC | -4.3 | -11.1 | histidinol-phosphate aminotransferase (NCBI) | compare |
| b4245 | pyrB | -4.2 | -14.2 | aspartate carbamoyltransferase catalytic subunit (NCBI) | compare |
| b2501 | ppk | -4.2 | -18.9 | polyphosphate kinase (NCBI) | compare |
| b3172 | argG | -4.2 | -20.1 | argininosuccinate synthase (NCBI) | compare |
| b2830 | nudH | -4.2 | -2.9 | dinucleoside polyphosphate hydrolase (NCBI) | compare |
| b3642 | pyrE | -4.1 | -7.5 | orotate phosphoribosyltransferase (NCBI) | compare |
| b3870 | glnA | -4.1 | -6.3 | glutamine synthetase (NCBI) | compare |
| b0078 | ilvH | -4.1 | -16.1 | acetolactate synthase small subunit (NCBI) | compare |
| b2762 | cysH | -4.0 | -13.3 | phosphoadenosine phosphosulfate reductase (NCBI) | compare |
| b0049 | apaH | -4.0 | -6.4 | diadenosinetetraphosphatase (NCBI) | compare |
| b0077 | ilvI | -4.0 | -17.8 | acetolactate synthase III large subunit (NCBI) | compare |
| b4013 | metA | -4.0 | -7.7 | homoserine O-succinyltransferase (NCBI) | compare |
| b0032 | carA | -4.0 | -12.5 | carbamoyl-phosphate synthase small subunit (NCBI) | compare |
| b1062 | pyrC | -4.0 | -13.8 | dihydroorotase (NCBI) | compare |
| b0726 | sucA | -4.0 | -7.6 | alpha-ketoglutarate decarboxylase (NCBI) | compare |
| b3959 | argB | -4.0 | -21.0 | acetylglutamate kinase (RefSeq) | compare |
| b3957 | argE | -3.9 | -21.3 | acetylornithine deacetylase (NCBI) | compare |
| b2750 | cysC | -3.9 | -9.4 | adenylylsulfate kinase (NCBI) | compare |
| b1262 | trpC | -3.9 | -6.3 | N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase (VIMSS) | compare |
| b2818 | argA | -3.8 | -15.5 | N-acetylglutamate synthase (NCBI) | compare |
| b2024 | hisA | -3.8 | -4.9 | N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'- phosphoribosyl)-4-imidazolecarboxamide isomerase (VIMSS) | compare |
| b3671 | ilvB | -3.7 | -20.6 | acetolactate synthase large subunit (NCBI) | compare |
| b0113 | pdhR | -3.7 | -8.2 | transcriptional regulator of pyruvate dehydrogenase complex (NCBI) | compare |
| b2763 | cysI | -3.7 | -16.7 | sulfite reductase, beta subunit, NAD(P)-binding, heme-binding (NCBI) | compare |
| b0945 | pyrD | -3.7 | -19.7 | dihydroorotate dehydrogenase (NCBI) | compare |
| b2026 | hisI | -3.7 | -9.0 | bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein (NCBI) | compare |
| b1281 | pyrF | -3.7 | -5.2 | orotidine 5'-phosphate decarboxylase (NCBI) | compare |
| b3958 | argC | -3.6 | -18.3 | N-acetyl-gamma-glutamyl-phosphate reductase (NCBI) | compare |
| b2764 | cysJ | -3.6 | -17.9 | sulfite reductase, alpha subunit, flavoprotein (NCBI) | compare |
| b4214 | cysQ | -3.6 | -16.5 | PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase (NCBI) | compare |
| b0439 | lon | -3.5 | -11.4 | DNA-binding ATP-dependent protease La (NCBI) | compare |
| b3008 | metC | -3.5 | -17.5 | cystathionine beta-lyase (NCBI) | compare |
| b2414 | cysK | -3.5 | -16.6 | cysteine synthase A, O-acetylserine sulfhydrolase A subunit (NCBI) | compare |
| b2019 | hisG | -3.4 | -4.2 | ATP phosphoribosyltransferase (NCBI) | compare |
| b0437 | clpP | -3.4 | -8.6 | ATP-dependent Clp protease proteolytic subunit (NCBI) | compare |
| b2752 | cysD | -3.3 | -11.7 | sulfate adenylyltransferase subunit 2 (NCBI) | compare |
| b2479 | gcvR | -3.3 | -9.1 | transcriptional regulation of gcv operon (VIMSS) | compare |
| b0740 | tolB | -3.3 | -8.6 | translocation protein TolB precursor (NCBI) | compare |
| b2839 | lysR | -3.3 | -8.5 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b0737 | tolQ | -3.2 | -6.1 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b1861 | ruvA | -3.2 | -3.2 | Holliday junction DNA helicase motor protein (NCBI) | compare |
| b3773 | ilvY | -3.2 | -12.2 | DNA-binding transcriptional dual regulator (NCBI) | compare |
| b2599 | pheA | -3.2 | -6.8 | fused chorismate mutase P/prephenate dehydratase (NCBI) | compare |
| b3368 | cysG | -3.2 | -22.0 | fused siroheme synthase 1,3-dimethyluroporphyriongen III dehydrogenase and siroheme ferrochelatase/uroporphyrinogen methyltransferase (NCBI) | compare |
| b3916 | pfkA | -3.2 | -6.1 | 6-phosphofructokinase (NCBI) | compare |
| b0889 | lrp | -3.2 | -7.4 | DNA-binding transcriptional dual regulator, leucine-binding (NCBI) | compare |
| b0720 | gltA | -3.1 | -10.6 | citrate synthase (NCBI) | compare |
| b3390 | aroK | -3.1 | -3.5 | shikimate kinase I (NCBI) | compare |
| b0739 | tolA | -3.1 | -7.3 | cell envelope integrity inner membrane protein TolA (NCBI) | compare |
| b2751 | cysN | -3.0 | -12.1 | sulfate adenylyltransferase subunit 1 (NCBI) | compare |
| b0738 | tolR | -2.9 | -6.4 | membrane spanning protein in TolA-TolQ-TolR complex (NCBI) | compare |
| b3619 | rfaD | -2.7 | -7.8 | ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding (NCBI) | compare |
| b2935 | tktA | -2.7 | -3.6 | transketolase 1, thiamin-binding (NCBI) | compare |
| b3204 | ptsN | -2.7 | -10.3 | sugar-specific enzyme IIA component of PTS (NCBI) | compare |
| b0200 | gmhB | -2.6 | -3.5 | hypothetical protein (NCBI) | compare |
| b3650 | spoT | -2.5 | -10.9 | bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase (NCBI) | compare |
| b1264 | trpE | -2.5 | -5.9 | anthranilate synthase component I (NCBI) | compare |
| b4177 | purA | -2.4 | -1.6 | adenylosuccinate synthetase (NCBI) | compare |
| b4171 | miaA | -2.3 | -4.7 | tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) | compare |
| b0683 | fur | -2.3 | -3.1 | ferric uptake regulator (NCBI) | compare |
| b3672 | ivbL | -2.3 | -4.1 | ilvB operon leader peptide (NCBI) | compare |
| b3290 | trkA | -2.3 | -5.3 | potassium transporter peripheral membrane component (NCBI) | compare |
| b2424 | cysU | -2.2 | -6.0 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3398 | yrfF | -2.2 | -8.4 | predicted inner membrane protein (NCBI) | compare |
| b1677 | lpp | -2.2 | -4.5 | murein lipoprotein (NCBI) | compare |
| b0928 | aspC | -2.2 | -11.9 | aspartate aminotransferase, PLP-dependent (NCBI) | compare |
| b0741 | pal | -2.2 | -7.3 | peptidoglycan-associated outer membrane lipoprotein (NCBI) | compare |
| b4025 | pgi | -2.2 | -13.4 | glucose-6-phosphate isomerase (NCBI) | compare |
| b3621 | rfaC | -2.2 | -10.1 | ADP-heptose:LPS heptosyl transferase I (NCBI) | compare |
| b2518 | ndk | -2.2 | -4.6 | nucleoside diphosphate kinase (NCBI) | compare |
| b3035 | tolC | -2.1 | -13.2 | outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) | compare |
| b0630 | lipB | -2.1 | -2.4 | protein of lipoate biosynthesis (VIMSS) | compare |
| b2567 | rnc | -2.1 | -2.4 | ribonuclease III (NCBI) | compare |
| b3741 | gidA | -2.1 | -8.8 | glucose-inhibited division protein A (NCBI) | compare |
| b2422 | cysA | -2.1 | -13.4 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b3781 | trxA | -2.1 | -7.1 | thioredoxin 1 (VIMSS) | compare |
| b2423 | cysW | -2.1 | -9.3 | sulfate/thiosulfate transporter subunit (NCBI) | compare |
| b1860 | ruvB | -2.1 | -1.9 | Holliday junction DNA helicase B (NCBI) | compare |
| b4676 | yoaK | -2.0 | -1.3 | expressed protein (RefSeq) | compare |
| b1712 | ihfA | -2.0 | -3.5 | integration host factor subunit alpha (NCBI) | compare |
| b1290 | sapF | -2.0 | -3.3 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b0767 | ybhE | -1.9 | -7.4 | 6-phosphogluconolactonase (NCBI) | compare |
| b2318 | truA | -1.9 | -5.1 | tRNA pseudouridine synthase A (NCBI) | compare |
| b0912 | ihfB | -1.9 | -7.0 | integration host factor subunit beta (NCBI) | compare |
| b2340 | sixA | -1.9 | -6.8 | phosphohistidine phosphatase (NCBI) | compare |
| b1506 | yneL | -1.9 | -2.9 | predicted transcriptional regulator (NCBI) | compare |
| b3828 | metR | -1.8 | -10.3 | DNA-binding transcriptional activator, homocysteine-binding (NCBI) | compare |
| b3670 | ilvN | -1.8 | -9.2 | acetolactate synthase small subunit (NCBI) | compare |
| b3053 | glnE | -1.8 | -7.4 | fused deadenylyltransferase/adenylyltransferase for glutamine synthetase (NCBI) | compare |
| b3052 | rfaE | -1.8 | -8.1 | fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase (NCBI) | compare |
| b3613 | yibP | -1.8 | -7.3 | putative membrane protein (VIMSS) | compare |
| b3839 | tatC | -1.8 | -8.9 | TatABCE protein translocation system subunit (NCBI) | compare |
| b0890 | ftsK | -1.8 | -8.2 | DNA-binding membrane protein required for chromosome resolution and partitioning (NCBI) | compare |
| b0114 | aceE | -1.8 | -1.7 | pyruvate dehydrogenase subunit E1 (NCBI) | compare |
| b2894 | xerD | -1.8 | -2.3 | site-specific tyrosine recombinase XerD (NCBI) | compare |
| b3247 | cafA | -1.7 | -12.6 | bundles of cytoplasmic filaments (VIMSS) | compare |
| b2846 | yqeH | -1.6 | -1.3 | orf, hypothetical protein (VIMSS) | compare |
| b3236 | mdh | -1.6 | -9.9 | malate dehydrogenase (NCBI) | compare |
| b2853 | ygeI | -1.6 | -0.9 | hypothetical protein (NCBI) | compare |
| b0075 | leuL | -1.6 | -3.2 | leu operon leader peptide (NCBI) | compare |
| b0438 | clpX | -1.6 | -7.9 | ATP-dependent protease ATP-binding subunit (NCBI) | compare |
| b3026 | qseC | -1.5 | -6.0 | sensory histidine kinase in two-component regulatory system with QseB (NCBI) | compare |
| b0222 | lpcA | -1.5 | -4.0 | phosphoheptose isomerase (NCBI) | compare |
| b1292 | sapC | -1.5 | -4.2 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b3849 | trkH | -1.5 | -11.1 | potassium transporter (NCBI) | compare |
| b0142 | folK | -1.5 | -0.7 | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase (NCBI) | compare |
| b3706 | trmE | -1.5 | -6.1 | tRNA modification GTPase (NCBI) | compare |
| b3620 | rfaF | -1.5 | -7.2 | ADP-heptose:LPS heptosyltransferase II (NCBI) | compare |
| b4042 | dgkA | -1.5 | -3.7 | diacylglycerol kinase (NCBI) | compare |
| b0592 | fepB | -1.4 | -10.5 | iron-enterobactin transporter subunit (NCBI) | compare |
| b0585 | fes | -1.4 | -6.0 | enterobactin/ferric enterobactin esterase (NCBI) | compare |
| b2500 | purN | -1.4 | -4.8 | phosphoribosylglycinamide formyltransferase (NCBI) | compare |
| b0755 | gpmA | -1.4 | -7.4 | phosphoglyceromutase (NCBI) | compare |
| b3493 | pitA | -1.3 | -9.2 | phosphate transporter, low-affinity (NCBI) | compare |
| b2911 | ssrS | -1.3 | -2.2 | 6S regulatory RNA (NCBI) | compare |
| b1830 | prc | -1.3 | -7.2 | carboxy-terminal protease for penicillin-binding protein 3 (NCBI) | compare |
| b1176 | minC | -1.3 | -3.9 | septum formation inhibitor (NCBI) | compare |
| b2611 | ypjD | -1.3 | -8.4 | predicted inner membrane protein (RefSeq) | compare |
| b1185 | dsbB | -1.3 | -5.1 | reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) | compare |
| b2313 | cvpA | -1.3 | -4.1 | membrane protein required for colicin V production (NCBI) | compare |
| b2684 | mprA | -1.3 | -4.6 | DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) | compare |
| b2029 | gnd | -1.3 | -8.0 | 6-phosphogluconate dehydrogenase (NCBI) | compare |
| b4481 | rffT | -1.3 | -7.0 | 4-alpha-L-fucosyltransferase (NCBI) | compare |
| b2064 | asmA | -1.2 | -8.0 | predicted assembly protein (NCBI) | compare |
| b0590 | fepD | -1.2 | -7.3 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2822 | recC | -1.2 | -5.9 | exonuclease V (RecBCD complex), gamma chain (NCBI) | compare |
| b0564 | appY | -1.2 | -1.0 | DLP12 prophage; DNA-binding transcriptional activator (NCBI) | compare |
| b3811 | xerC | -1.2 | -2.4 | site-specific tyrosine recombinase XerC (NCBI) | compare |
| b4146 | yjeK | -1.2 | -3.2 | predicted lysine aminomutase (NCBI) | compare |
| b2699 | recA | -1.1 | -2.2 | recombinase A (NCBI) | compare |
| b3169 | nusA | -1.1 | -2.2 | transcription elongation factor NusA (NCBI) | compare |
| b3844 | fre | -1.1 | -7.4 | NAD(P)H-flavin reductase (NCBI) | compare |
| b2425 | cysP | -1.1 | -4.3 | thiosulfate transporter subunit (NCBI) | compare |
| b3237 | argR | -1.1 | -5.1 | arginine repressor (NCBI) | compare |
| b0189 | yaeO | -1.1 | -6.3 | orf, hypothetical protein (VIMSS) | compare |
| b0589 | fepG | -1.1 | -7.2 | iron-enterobactin transporter subunit (NCBI) | compare |
| b2820 | recB | -1.1 | -2.5 | exonuclease V (RecBCD complex), beta subunit (NCBI) | compare |
| b1863 | ruvC | -1.1 | -2.9 | Holliday junction resolvase (NCBI) | compare |
| b4480 | hdfR | -1.1 | -5.8 | transcriptional regulator HdfR (NCBI) | compare |
| b0588 | fepC | -1.1 | -5.0 | iron-enterobactin transporter subunit (NCBI) | compare |
| b1291 | sapD | -1.1 | -2.3 | predicted antimicrobial peptide transporter subunit (NCBI) | compare |
| b1351 | racC | -1.1 | -0.7 | Rac prophage; predicted protein (NCBI) | compare |
| b3405 | ompR | -1.1 | -6.5 | osmolarity response regulator (NCBI) | compare |
| b3860 | dsbA | -1.1 | -7.6 | periplasmic protein disulfide isomerase I (NCBI) | compare |
| b2528 | iscA | -1.0 | -2.8 | iron-sulfur cluster assembly protein (NCBI) | compare |
| b1101 | ptsG | -1.0 | -8.2 | fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) | compare |
| b3630 | rfaP | -1.0 | -8.3 | kinase that phosphorylates core heptose of lipopolysaccharide (NCBI) | compare |
| b3725 | pstB | -1.0 | -1.6 | phosphate transporter subunit (NCBI) | compare |
| b1040 | csgD | -1.0 | -2.0 | DNA-binding transcriptional activator in two-component regulatory system (NCBI) | compare |
| b3842 | rfaH | -1.0 | -5.4 | transcriptional activator RfaH (NCBI) | compare |
| b4390 | nadR | -1.0 | -7.4 | probable nadAB transcriptional regulator (VIMSS) | compare |
| b4048 | yjbM | -1.0 | -2.2 | hypothetical protein (NCBI) | compare |