Experiment set1IT031 for Escherichia coli BW25113

Compare to:

Sodium D-Lactate carbon source

200 most detrimental genes:

  gene name fitness t score description  
b3341 rpsG +2.2 4.8 30S ribosomal protein S7 (NCBI) compare
b3753 rbsR +2.2 16.3 DNA-binding transcriptional repressor of ribose metabolism (NCBI) compare
b2741 rpoS +2.1 11.2 RNA polymerase sigma factor (NCBI) compare
b1422 ydcI +1.8 8.2 putative transcriptional regulator LYSR-type (VIMSS) conserved
b4373 rimI +1.7 5.2 ribosomal-protein-alanine N-acetyltransferase (NCBI) compare
b3199 yrbK +1.6 5.5 hypothetical protein (NCBI) compare
b1085 b1085 +1.4 3.4 orf, hypothetical protein (VIMSS) compare
b1824 yobF +1.4 6.3 hypothetical protein (NCBI) compare
b3929 rraA +1.4 8.3 ribonuclease activity regulator protein RraA (NCBI) compare
b1823 cspC +1.4 3.1 stress protein, member of the CspA-family (NCBI) compare
b0240 crl +1.4 6.8 DNA-binding transcriptional regulator (NCBI) compare
b4450 arcZ +1.3 2.8 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b1095 fabF +1.2 8.0 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b2229 b2229 +1.2 1.8 orf, hypothetical protein (VIMSS) compare
b2314 dedD +1.2 4.9 putative lipoprotein (VIMSS) compare
b3261 fis +1.1 4.1 DNA-binding protein Fis (NCBI) compare
b0232 yafN +1.1 1.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0920 ycbC +1.1 5.0 conserved inner membrane protein (NCBI) compare
b4172 hfq +1.1 2.7 RNA-binding protein Hfq (NCBI) compare
b4000 hupA +1.0 6.1 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b2784 relA +1.0 7.9 (p)ppGpp synthetase I/GTP pyrophosphokinase (NCBI) compare
b3229 sspA +1.0 5.0 stringent starvation protein A (NCBI) compare
b2829 ptsP +1.0 7.6 fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein (NCBI) compare
b2007 yeeX +1.0 2.4 conserved protein (RefSeq) compare
b0382 yaiB +1.0 6.4 hypothetical protein (NCBI) compare
b2446 yffO +1.0 2.5 CPZ-55 prophage; predicted protein (NCBI) compare
b2058 wcaB +1.0 1.3 predicted acyl transferase (NCBI) compare
b4071 nrfB +0.9 1.9 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b1066 rimJ +0.9 4.6 ribosomal-protein-S5-alanine N-acetyltransferase (NCBI) compare
b0059 hepA +0.9 7.0 ATP-dependent helicase HepA (NCBI) compare
b3494 yhiO +0.9 4.3 universal stress protein UspB (NCBI) compare
b2317 dedA +0.9 2.6 conserved inner membrane protein (NCBI) compare
b3740 gidB +0.8 5.7 glucose-inhibited division protein B (NCBI) compare
b0015 dnaJ +0.8 5.3 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b3933 ftsN +0.8 6.4 essential cell division protein (NCBI) compare
b1332 ynaJ +0.8 1.8 predicted inner membrane protein (NCBI) compare
b4627 ykfL +0.8 3.6 no description compare
b1725 yniA +0.8 3.7 predicted phosphotransferase/kinase (NCBI) compare
b3752 rbsK +0.8 4.0 ribokinase (NCBI) compare
b3181 greA +0.8 3.4 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b4406 yaeP +0.8 1.5 hypothetical protein (NCBI) compare
b3636 rpmG +0.8 1.9 50S ribosomal protein L33 (NCBI) compare
b0014 dnaK +0.8 2.0 molecular chaperone DnaK (NCBI) compare
b2814 metZ +0.8 1.5 tRNA-Met (NCBI) compare
b1104 ycfL +0.8 2.4 hypothetical protein (NCBI) compare
b1667 ydhR +0.7 2.4 hypothetical protein (NCBI) compare
b1400 paaY +0.7 1.9 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b4049 dusA +0.7 5.1 tRNA-dihydrouridine synthase A (RefSeq) compare
b2911 ssrS +0.7 1.5 6S regulatory RNA (NCBI) compare
b3183 obgE +0.7 1.8 GTPase involved in cell partioning and DNA repair (NCBI) compare
b2377 yfdY +0.7 2.5 predicted inner membrane protein (NCBI) compare
b3133 agaV +0.7 2.4 PTS system, cytoplasmic, N-acetylgalactosamine-specific IIB component 2 (EIIB-AGA) (VIMSS) compare
b3157 yhbT +0.7 2.8 predicted lipid carrier protein (NCBI) compare
b0784 moaD +0.7 2.5 molybdopterin synthase, small subunit (NCBI) compare
b1831 proQ +0.7 1.7 putative solute/DNA competence effector (NCBI) compare
b0051 ksgA +0.7 3.5 dimethyladenosine transferase (NCBI) compare
b1959 yedA +0.7 2.8 predicted inner membrane protein (NCBI) compare
b0050 apaG +0.7 4.0 hypothetical protein (NCBI) compare
b0955 ycbZ +0.7 4.0 predicted peptidase (NCBI) compare
b1222 narX +0.7 3.1 sensory histidine kinase in two-component regulatory system with NarL (NCBI) compare
b0765 modC +0.7 2.7 molybdate transporter subunit (NCBI) compare
b0191 yaeJ +0.7 2.2 hypothetical protein (NCBI) compare
b1148 ymfM +0.7 2.2 e14 prophage; predicted protein (NCBI) compare
b3769 ilvM +0.7 2.3 acetolactate synthase II, small subunit (NCBI) compare
b3644 yicC +0.7 3.1 hypothetical protein (NCBI) compare
b1944 fliL +0.6 3.4 flagellar basal body-associated protein FliL (NCBI) compare
b1960 vsr +0.6 2.6 DNA mismatch endonuclease of very short patch repair (NCBI) compare
b0953 rmf +0.6 1.9 ribosome modulation factor (NCBI) compare
b1399 paaX +0.6 1.9 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive (NCBI) compare
b2183 rsuA +0.6 2.5 16S rRNA pseudouridylate 516 synthase (NCBI) compare
b2435 amiA +0.6 2.4 N-acetylmuramoyl-l-alanine amidase I (NCBI) compare
b4402 yjjY +0.6 0.9 hypothetical protein (NCBI) compare
b4568 ytjA +0.6 1.3 predicted protein (RefSeq) compare
b3198 kdsC +0.6 1.7 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (NCBI) compare
b4570 lomR +0.6 1.2 no description compare
b2393 nupC +0.6 3.6 nucleoside (except guanosine) transporter (NCBI) compare
b0549 ybcO +0.6 1.7 DLP12 prophage; predicted protein (NCBI) compare
b1841 yobA +0.6 1.0 hypothetical protein (NCBI) compare
b0225 yafQ +0.6 2.4 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0643 ybeL +0.6 3.4 hypothetical protein (NCBI) compare
b0503 ybbB +0.6 1.4 tRNA 2-selenouridine synthase, selenophosphate-dependent (NCBI) compare
b1758 b1758 +0.6 0.9 putative cytochrome oxidase (VIMSS) compare
b1143 ymfI +0.6 1.4 orf, hypothetical protein (VIMSS) compare
b4546 ypeB +0.6 0.9 hypothetical protein (NCBI) compare
b0018 mokC +0.6 0.9 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b1380 ldhA +0.6 1.0 D-lactate dehydrogenase (NCBI) compare
b2576 srmB +0.6 2.6 ATP-dependent RNA helicase (NCBI) compare
b4578 insP +0.6 1.9 no description compare
b2666 yqaE +0.6 1.4 predicted membrane protein (NCBI) compare
b4458 oxyS +0.6 0.8 global regulatory RNA (NCBI) compare
b0852 rimK +0.6 2.4 ribosomal protein S6 modification protein (NCBI) compare
b0082 mraW +0.6 2.3 S-adenosyl-methyltransferase (NCBI) compare
b1518 lsrG +0.6 1.5 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b4390 nadR +0.6 4.1 probable nadAB transcriptional regulator (VIMSS) compare
b1757 b1757 +0.6 2.2 putative thiosulfate sulfur transferase (VIMSS) compare
b4294 insA-7 +0.6 1.1 KpLE2 phage-like element; IS1 repressor protein InsA (NCBI) compare
b4653 yicT +0.6 1.6 no description compare
b4443 gcvB +0.6 1.1 GcvB sRNA gene divergent from gcvA (RefSeq) compare
b2910 zapA +0.6 2.0 protein that localizes to the cytokinetic ring (NCBI) compare
b4371 rsmC +0.6 2.8 16S ribosomal RNA m2G1207 methyltransferase (NCBI) compare
b2051 wcaH +0.5 0.9 GDP-mannose mannosyl hydrolase (VIMSS) compare
b1640 ydhH +0.5 1.6 anhydro-N-acetylmuramic acid kinase (NCBI) compare
b0865 ybjP +0.5 2.2 predicted lipoprotein (NCBI) compare
b2823 ppdC +0.5 2.1 hypothetical protein (NCBI) compare
b4477 dgoA +0.5 2.6 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (NCBI) compare
b2080 b2080 +0.5 1.0 orf, hypothetical protein (VIMSS) compare
b1512 lsrR +0.5 2.2 lsr operon transcriptional repressor (NCBI) compare
b2209 eco +0.5 1.6 ecotin precursor (NCBI) compare
b1329 b1329 +0.5 3.4 putative transport periplasmic protein (VIMSS) compare
b1200 b1200 +0.5 3.0 putative dihydroxyacetone kinase (EC 2.7.1.2) (VIMSS) compare
b2262 menB +0.5 0.9 naphthoate synthase (NCBI) compare
b4595 yciY +0.5 1.3 hypothetical protein (RefSeq) compare
b0785 moaE +0.5 2.3 molybdopterin synthase, large subunit (NCBI) compare
b2291 yfbR +0.5 2.1 hypothetical protein (NCBI) compare
b1523 yneG +0.5 1.5 hypothetical protein (NCBI) compare
b3119 tdcR +0.5 1.6 threonine dehydratase operon activator protein (VIMSS) compare
b1847 yebF +0.5 1.1 predicted protein (RefSeq) compare
b3238 yhcN +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b1259 yciG +0.5 1.1 orf, hypothetical protein (VIMSS) compare
b1698 ydiR +0.5 2.1 predicted electron transfer flavoprotein, FAD-binding (NCBI) compare
b4631 ykgQ +0.5 1.0 no description compare
b0790 ybhP +0.5 2.9 predicted DNase (NCBI) compare
b1566 flxA +0.5 2.4 Qin prophage; predicted protein (NCBI) compare
b3500 gor +0.5 0.8 glutathione reductase (NCBI) compare
b0866 ybjQ +0.5 0.7 hypothetical protein (NCBI) compare
b2915 yqfE +0.5 1.3 hypothetical protein (RefSeq) compare
b1074 flgC +0.5 1.0 flagellar basal-body rod protein C (NCBI) compare
b0870 ltaE +0.5 1.3 L-allo-threonine aldolase, PLP-dependent (NCBI) compare
b2042 galF +0.5 3.4 predicted subunit with GalU (NCBI) compare
b1914 uvrY +0.5 2.3 response regulator (NCBI) compare
b4174 hflK +0.5 3.7 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b2809 b2809 +0.5 1.5 orf, hypothetical protein (VIMSS) compare
b4097 phnK +0.5 1.5 carbon-phosphorus lyase complex subunit (NCBI) compare
b2141 yohJ +0.5 1.8 hypothetical protein (NCBI) compare
b2012 yeeD +0.5 1.8 hypothetical protein (NCBI) compare
b2123 yehR +0.5 0.8 orf, hypothetical protein (VIMSS) compare
b1253 yciA +0.5 1.2 predicted hydrolase (NCBI) compare
b4695 ykgT +0.5 0.7 no description compare
b1918 yecS +0.5 1.2 predicted transporter subunit: membrane component of ABC superfamily (NCBI) compare
b2535 csiE +0.5 3.8 orf, hypothetical protein (VIMSS) compare
b0607 uspG +0.5 2.6 universal stress protein UP12 (NCBI) compare
b1822 rrmA +0.5 1.4 23S rRNA m1G745 methyltransferase (NCBI) compare
b0967 yccW +0.5 2.7 predicted methyltransferase (RefSeq) compare
b1223 narK +0.5 2.2 nitrate/nitrite transporter (NCBI) compare
b4511 ybdZ +0.5 1.8 hypothetical protein (NCBI) compare
b0610 rnk +0.5 1.6 nucleoside diphosphate kinase regulator (NCBI) compare
b2944 sprT +0.5 2.0 hypothetical protein (NCBI) compare
b1475 fdnH +0.5 2.6 formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible (NCBI) compare
b2959 yggL +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b4195 ulaC +0.5 1.9 L-ascorbate-specific enzyme IIA component of PTS (NCBI) compare
b2101 yegW +0.5 1.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b2004 yeeU +0.5 1.7 CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system (NCBI) compare
b4675 yoaJ +0.5 1.6 expressed protein (RefSeq) compare
b2571 rseB +0.5 2.9 periplasmic negative regulator of sigmaE (NCBI) compare
b1686 ydiI +0.5 1.7 hypothetical protein (NCBI) compare
b4699 fnrS +0.5 0.7 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b2905 gcvT +0.5 3.0 glycine cleavage system aminomethyltransferase T (NCBI) compare
b1648 b1648 +0.5 0.9 orf, hypothetical protein (VIMSS) compare
b2904 gcvH +0.4 1.5 glycine cleavage system protein H (NCBI) compare
b1343 dbpA +0.4 2.1 ATP-dependent RNA helicase, specific for 23S rRNA (NCBI) compare
b1838 pphA +0.4 2.5 protein phosphatase 1 modulates phosphoproteins, signals protein misfolding (VIMSS) compare
b2811 ygdK +0.4 1.7 predicted Fe-S metabolism protein (NCBI) compare
b1926 fliT +0.4 1.7 predicted chaperone (NCBI) compare
b2057 wcaC +0.4 1.6 predicted glycosyl transferase (NCBI) compare
b2704 srlB +0.4 1.6 glucitol/sorbitol-specific enzyme IIA component of PTS (NCBI) compare
b0487 cueR +0.4 2.0 DNA-binding transcriptional activator of copper-responsive regulon genes (NCBI) compare
b1743 spy +0.4 1.2 envelope stress induced periplasmic protein (NCBI) compare
b1372 b1372 +0.4 2.2 putative membrane protein (VIMSS) compare
b3095 yqjA +0.4 2.5 conserved inner membrane protein (NCBI) compare
b1802 yeaW +0.4 2.2 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b3206 npr +0.4 1.8 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) (NCBI) compare
b2448 yffQ +0.4 2.1 CPZ-55 prophage; predicted protein (RefSeq) compare
b1562 hokD +0.4 1.1 Qin prophage; small toxic polypeptide (NCBI) compare
b1548 nohA +0.4 1.1 Qin prophage; predicted packaging protein (RefSeq) compare
b4548 ypjJ +0.4 2.1 hypothetical protein (NCBI) compare
b4175 hflC +0.4 3.0 modulator for HflB protease specific for phage lambda cII repressor (NCBI) compare
b1067 yceH +0.4 1.1 hypothetical protein (NCBI) compare
b3718 yieK +0.4 1.9 hypothetical protein (NCBI) compare
b0458 ylaC +0.4 2.6 orf, hypothetical protein (VIMSS) compare
b1848 yebG +0.4 0.6 conserved protein regulated by LexA (NCBI) compare
b3888 yiiD +0.4 3.0 predicted acetyltransferase (NCBI) compare
b2151 galS +0.4 2.0 DNA-binding transcriptional repressor (NCBI) compare
b2597 yfiA +0.4 0.8 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b0550 rusA +0.4 1.2 DLP12 prophage; endonuclease RUS (NCBI) compare
b1191 b1191 +0.4 2.3 orf, hypothetical protein (VIMSS) compare
b0468 ybaN +0.4 1.8 conserved inner membrane protein (NCBI) compare
b4545 ypdJ +0.4 1.5 no description compare
b2510 b2510 +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b2786 barA +0.4 3.8 hybrid sensory histidine kinase, in two-component regulatory system with UvrY (NCBI) compare
b2199 ccmC +0.4 1.7 heme exporter subunit (NCBI) compare
b2474 ypfI +0.4 2.9 predicted hydrolase (NCBI) compare
b1842 holE +0.4 1.0 DNA polymerase III, theta subunit (NCBI) compare
b3778 rep +0.4 2.9 DNA helicase and single-stranded DNA-dependent ATPase (NCBI) compare
b2248 yfaX +0.4 1.4 predicted DNA-binding transcriptional regulator (NCBI) compare
b4515 ybgT +0.4 0.7 hypothetical protein (NCBI) compare
b3293 yhdN +0.4 1.4 hypothetical protein (NCBI) compare
b4609 ryfD +0.4 1.3 Novel sRNA, function unknown (RefSeq) compare
b2665 ygaU +0.4 1.3 hypothetical protein (NCBI) compare
b0711 ybgJ +0.4 1.9 predicted enzyme subunit (NCBI) compare
b3248 yhdE +0.4 2.8 Maf-like protein (NCBI) compare


Specific Phenotypes

For 10 genes in this experiment

For carbon source Sodium D-Lactate in Escherichia coli BW25113

For carbon source Sodium D-Lactate across organisms