Experiment set10IT076 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Phenazine ethosulfate 0.000125 mM

200 most detrimental genes:

  gene name fitness t score description  
b1185 dsbB +2.8 8.3 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b2113 mrp +2.5 12.9 putative ATPase (VIMSS) compare
b1764 selD +2.3 14.3 selenophosphate synthetase (NCBI) compare
b2279 nuoK +2.3 4.6 NADH dehydrogenase subunit K (NCBI) compare
b2688 gshA +2.2 13.5 glutamate--cysteine ligase (NCBI) compare
b3860 dsbA +2.2 14.5 periplasmic protein disulfide isomerase I (NCBI) compare
b3893 fdoH +2.2 17.9 formate dehydrogenase-O, Fe-S subunit (NCBI) compare
b3591 selA +2.2 19.6 selenocysteine synthase (NCBI) compare
b3892 fdoI +2.2 15.9 formate dehydrogenase-O, cytochrome b556 subunit (NCBI) compare
b3590 selB +2.2 18.7 selenocysteinyl-tRNA-specific translation factor (NCBI) compare
b3894 fdoG +2.2 19.6 formate dehydrogenase-O, large subunit (NCBI) compare
b2618 b2618 +2.2 6.2 orf, hypothetical protein (VIMSS) compare
b1627 rsxA +2.1 6.7 Na(+)-translocating NADH-quinone reductase subunit E (NCBI) compare
b3169 nusA +2.1 5.7 transcription elongation factor NusA (NCBI) compare
b3806 cyaA +2.1 9.6 adenylate cyclase (NCBI) compare
b3891 fdhE +2.0 16.0 formate dehydrogenase accessory protein FdhE (NCBI) compare
b3895 fdhD +2.0 14.3 formate dehydrogenase accessory protein (NCBI) compare
b1630 rsxD +2.0 9.9 electron transport complex protein RnfD (NCBI) compare
b3844 fre +2.0 13.2 NAD(P)H-flavin reductase (NCBI) compare
b1632 rsxE +1.9 9.6 NADH-ubiquinone oxidoreductase (NCBI) compare
b2214 yojL +1.9 10.6 predicted thiamine biosynthesis lipoprotein (NCBI) compare
b0464 acrR +1.9 14.7 DNA-binding transcriptional repressor (NCBI) compare
b2947 gshB +1.9 8.6 glutathione synthetase (NCBI) compare
b3658 selC +1.8 4.7 tRNA-Sec (NCBI) compare
b3977 tyrU +1.8 1.8 tRNA-Tyr (NCBI) compare
b0683 fur +1.7 3.7 ferric uptake regulator (NCBI) compare
b0764 modB +1.6 7.6 molybdate ABC transporter permease protein (NCBI) compare
b0439 lon +1.5 7.7 DNA-binding ATP-dependent protease La (NCBI) compare
b0765 modC +1.5 8.6 molybdate transporter subunit (NCBI) compare
b0763 modA +1.5 8.9 molybdate transporter subunit (NCBI) compare
b1628 rsxB +1.5 3.6 electron transport complex protein RnfB (NCBI) compare
b3414 gntY +1.5 7.8 predicted gluconate transport associated protein (NCBI) compare
b1629 rsxC +1.5 7.0 electron transport complex protein RnfC (NCBI) compare
b2283 nuoG +1.5 9.0 NADH:ubiquinone oxidoreductase, chain G (RefSeq) compare
b2377 yfdY +1.4 3.6 predicted inner membrane protein (NCBI) compare
b4538 yoeF +1.4 2.1 hypothetical protein (RefSeq) compare
b4221 ytfN +1.4 12.2 hypothetical protein (NCBI) compare
b4220 ytfM +1.3 10.9 predicted outer membrane protein and surface antigen (NCBI) compare
b0726 sucA +1.3 5.5 alpha-ketoglutarate decarboxylase (NCBI) compare
b0015 dnaJ +1.3 7.8 chaperone Hsp40, co-chaperone with DnaK (NCBI) compare
b0858 ybjO +1.3 3.6 predicted inner membrane protein (NCBI) compare
b0125 hpt +1.3 5.5 hypoxanthine phosphoribosyltransferase (VIMSS) compare
b2286 nuoC +1.3 7.3 NADH:ubiquinone oxidoreductase, chain C,D (RefSeq) compare
b2570 rseC +1.3 6.5 RseC protein involved in reduction of the SoxR iron-sulfur cluster (NCBI) compare
b2934 cmtB +1.3 1.2 predicted mannitol-specific enzyme IIA component of PTS (NCBI) compare
b0826 moeB +1.3 7.9 molybdopterin biosynthesis protein MoeB (NCBI) compare
b0827 moeA +1.2 6.9 molybdopterin biosynthesis protein (NCBI) compare
b1882 cheY +1.2 0.7 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b2531 iscR +1.2 1.9 DNA-binding transcriptional repressor (NCBI) compare
b0798 ybiA +1.2 3.4 hypothetical protein (NCBI) compare
b0783 moaC +1.2 5.2 molybdenum cofactor biosynthesis protein C (NCBI) compare
b2285 nuoE +1.2 3.0 NADH dehydrogenase subunit E (NCBI) compare
b0784 moaD +1.1 2.4 molybdopterin synthase, small subunit (NCBI) compare
b1252 tonB +1.1 4.1 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2277 nuoM +1.1 6.0 NADH dehydrogenase subunit M (NCBI) compare
b2642 yfjW +1.1 0.8 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b1279 yciS +1.1 1.2 conserved inner membrane protein (NCBI) compare
b0781 moaA +1.1 6.8 molybdenum cofactor biosynthesis protein A (NCBI) compare
b2278 nuoL +1.1 7.1 NADH dehydrogenase subunit L (NCBI) compare
b2684 mprA +1.0 4.2 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux (NCBI) compare
b2282 nuoH +1.0 3.1 NADH dehydrogenase subunit H (NCBI) compare
b1263 trpD +1.0 2.2 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b2698 recX +1.0 3.0 RecA regulator RecX (NCBI) compare
b4241 treR +1.0 6.9 trehalose repressor (NCBI) compare
b3807 cyaY +1.0 4.8 frataxin-like protein (NCBI) compare
b1382 ynbE +1.0 1.6 predicted lipoprotein (NCBI) compare
b4596 yciZ +1.0 1.8 hypothetical protein (RefSeq) compare
b1524 yneH +1.0 0.8 predicted glutaminase (NCBI) compare
b2276 nuoN +1.0 3.4 NADH:ubiquinone oxidoreductase, membrane subunit N (RefSeq) compare
b0009 mog +1.0 6.1 molybdenum cofactor biosynthesis protein (NCBI) compare
b1553 ydfP +1.0 2.7 Qin prophage; conserved protein (NCBI) compare
b4171 miaA +1.0 2.9 tRNA delta(2)-isopentenylpyrophosphate transferase (NCBI) compare
b2708 gutQ +1.0 2.7 orf, hypothetical protein (VIMSS) compare
b1475 fdnH +0.9 3.4 formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible (NCBI) compare
b2951 yggS +0.9 3.5 predicted enzyme (NCBI) compare
b3006 exbB +0.9 6.0 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b2083 yegZ +0.9 1.2 orf, hypothetical protein (VIMSS) compare
b0785 moaE +0.9 4.9 molybdopterin synthase, large subunit (NCBI) compare
b1346 ydaQ +0.9 0.7 orf, hypothetical protein (VIMSS) compare
b4407 thiS +0.9 2.3 sulfur carrier protein ThiS (NCBI) compare
b2093 gatB +0.9 3.5 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b2614 grpE +0.9 1.5 heat shock protein (NCBI) compare
b2939 yqgB +0.9 1.2 predicted protein (RefSeq) compare
b2617 smpA +0.9 2.2 small membrane protein A (VIMSS) compare
b0429 cyoD +0.9 3.6 cytochrome o ubiquinol oxidase subunit IV (NCBI) compare
b2281 nuoI +0.9 2.6 NADH dehydrogenase subunit I (NCBI) compare
b1684 sufA +0.9 1.8 iron-sulfur cluster assembly scaffold protein (NCBI) compare
b2208 napF +0.9 2.9 ferredoxin-type protein, predicted role in electron transfer to periplasmic nitrate reductase (NapA) (NCBI) compare
b3836 b3836 +0.9 3.8 orf, hypothetical protein (VIMSS) compare
b1134 ymfB +0.9 2.1 bifunctional thiamin pyrimidine pyrophosphate hydrolase/ thiamin pyrophosphate hydrolase (NCBI) compare
b1486 ddpB +0.9 2.0 D-ala-D-ala transporter subunit (NCBI) compare
b0720 gltA +0.8 4.3 citrate synthase (NCBI) compare
b4418 sraB +0.8 1.2 unknown RNA (NCBI) compare
b1305 pspB +0.8 1.6 phage shock protein B (NCBI) compare
b2080 b2080 +0.8 1.6 orf, hypothetical protein (VIMSS) compare
b4699 fnrS +0.8 0.7 FNR-activated anaerobic sRNA antisense regulator down regulates cydDC, metE, sodA, sodB, Hfq-dependent; mediates negative FNR regulation (RefSeq) compare
b1095 fabF +0.8 3.9 3-oxoacyl-(acyl carrier protein) synthase (NCBI) compare
b1917 yecC +0.8 2.6 predicted transporter subunit: ATP-binding component of ABC superfamily (NCBI) compare
b3181 greA +0.8 2.5 transcription elongation factor: cleaves 3' nucleotide of paused mRNA (VIMSS) compare
b0418 pgpA +0.8 3.2 phosphatidylglycerophosphatase A (NCBI) compare
b1777 b1777 +0.8 2.1 orf, hypothetical protein (VIMSS) compare
b1959 yedA +0.8 2.2 predicted inner membrane protein (NCBI) compare
b0678 nagB +0.8 3.5 glucosamine-6-phosphate deaminase (NCBI) compare
b0724 sdhB +0.8 3.5 succinate dehydrogenase, FeS subunit (NCBI) compare
b1516 lsrB +0.8 2.0 AI2 transporter (NCBI) compare
b2419 yfeK +0.8 1.4 hypothetical protein (NCBI) compare
b0641 rlpB +0.8 0.8 minor lipoprotein (NCBI) compare
b2811 ygdK +0.7 2.7 predicted Fe-S metabolism protein (NCBI) compare
b2518 ndk +0.7 1.5 nucleoside diphosphate kinase (NCBI) compare
b1890 motA +0.7 1.8 flagellar motor protein MotA (NCBI) compare
b1699 ydiS +0.7 1.7 predicted oxidoreductase with FAD/NAD(P)-binding domain (NCBI) compare
b0430 cyoC +0.7 2.5 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b2284 nuoF +0.7 2.8 NADH:ubiquinone oxidoreductase, chain F (NCBI) compare
b3029 ygiN +0.7 2.2 quinol monooxygenase (NCBI) compare
b0926 ycbK +0.7 2.9 hypothetical protein (NCBI) compare
b2229 b2229 +0.7 2.0 orf, hypothetical protein (VIMSS) compare
b2288 nuoA +0.7 2.3 NADH dehydrogenase I chain A (VIMSS) compare
b1853 yebK +0.7 1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b3857 mobA +0.7 4.5 molybdopterin-guanine dinucleotide biosynthesis protein A (NCBI) compare
b1090 plsX +0.7 2.4 glycerolphosphate auxotrophy in plsB background (VIMSS) compare
b1677 lpp +0.7 1.7 murein lipoprotein (NCBI) compare
b1253 yciA +0.7 2.1 predicted hydrolase (NCBI) compare
b3493 pitA +0.7 4.3 phosphate transporter, low-affinity (NCBI) compare
b2448 yffQ +0.7 1.5 CPZ-55 prophage; predicted protein (RefSeq) compare
b2953 yggU +0.7 1.7 orf, hypothetical protein (VIMSS) compare
b1433 b1433 +0.7 1.9 putative membrane transport protein (VIMSS) compare
b2906 visC +0.7 3.9 hypothetical protein (NCBI) compare
b3257 yhdT +0.7 1.7 conserved inner membrane protein (NCBI) compare
b0840 deoR +0.7 2.1 DNA-binding transcriptional repressor (NCBI) compare
b2725 hycA +0.7 2.2 regulator of the transcriptional regulator FhlA (NCBI) compare
b3365 nirB +0.7 5.1 nitrite reductase, large subunit, NAD(P)H-binding (NCBI) compare
b0428 cyoE +0.7 3.6 protoheme IX farnesyltransferase (NCBI) compare
b2340 sixA +0.7 2.4 phosphohistidine phosphatase (NCBI) compare
b1577 ydfE +0.7 3.4 Qin prophage; predicted protein (RefSeq) compare
b2905 gcvT +0.7 3.7 glycine cleavage system aminomethyltransferase T (NCBI) compare
b0249 ykfF +0.7 2.0 CP4-6 prophage; predicted protein (NCBI) compare
b1412 azoR +0.7 1.6 acyl carrier protein phosphodiesterase (NCBI) compare
b1615 uidC +0.7 2.2 membrane-associated protein (VIMSS) compare
b1751 ydjY +0.7 2.2 orf, hypothetical protein (VIMSS) compare
b3611 yibN +0.7 2.4 predicted rhodanese-related sulfurtransferase (NCBI) compare
b2188 yejM +0.7 3.9 predicted hydrolase, inner membrane (NCBI) compare
b0920 ycbC +0.7 1.8 conserved inner membrane protein (NCBI) compare
b3341 rpsG +0.7 0.9 30S ribosomal protein S7 (NCBI) compare
b1806 yeaY +0.6 2.0 predicted lipoprotein (NCBI) compare
b3221 yhcH +0.6 2.8 hypothetical protein (NCBI) compare
b3151 yraQ +0.6 3.4 predicted permease (NCBI) compare
b3199 yrbK +0.6 1.1 hypothetical protein (NCBI) compare
b2280 nuoJ +0.6 2.8 NADH dehydrogenase subunit J (NCBI) compare
b3205 yhbJ +0.6 1.7 hypothetical protein (NCBI) compare
b0431 cyoB +0.6 4.1 cytochrome o ubiquinol oxidase subunit I (NCBI) compare
b0767 ybhE +0.6 2.4 6-phosphogluconolactonase (NCBI) compare
b2240 glpT +0.6 4.0 sn-glycerol-3-phosphate transporter (NCBI) compare
b1296 ycjJ +0.6 1.7 putative amino acid/amine transport protein (VIMSS) compare
b4533 ynfO +0.6 1.1 Qin prophage; predicted protein (NCBI) compare
b0723 sdhA +0.6 4.1 succinate dehydrogenase flavoprotein subunit (NCBI) compare
b4406 yaeP +0.6 1.0 hypothetical protein (NCBI) compare
b0987 ymcD +0.6 2.2 orf, hypothetical protein (VIMSS) compare
b2683 ygaH +0.6 2.7 predicted inner membrane protein (NCBI) compare
b3698 yidB +0.6 1.7 orf, hypothetical protein (VIMSS) compare
b3033 yqiB +0.6 1.7 predicted dehydrogenase (NCBI) compare
b4385 yjjJ +0.6 4.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b1467 narY +0.6 2.7 nitrate reductase 2 (NRZ), beta subunit (NCBI) compare
b0191 yaeJ +0.6 2.1 hypothetical protein (NCBI) compare
b1200 b1200 +0.6 2.6 putative dihydroxyacetone kinase (EC 2.7.1.2) (VIMSS) compare
b1587 ynfE +0.6 2.5 oxidoreductase subunit (NCBI) compare
b2597 yfiA +0.6 1.1 cold shock protein associated with 30S ribosomal subunit (NCBI) compare
b0432 cyoA +0.6 4.1 cytochrome o ubiquinol oxidase subunit II (NCBI) compare
b2587 kgtP +0.6 3.3 alpha-ketoglutarate transporter (NCBI) compare
b0427 yajR +0.6 3.6 putative transport protein (VIMSS) compare
b1633 nth +0.6 2.3 DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III) (NCBI) compare
b1680 sufS +0.6 3.2 selenocysteine lyase (NCBI) compare
b2586 yfiM +0.6 2.0 predicted protein (RefSeq) compare
b3522 yhjD +0.6 3.5 conserved inner membrane protein (NCBI) compare
b1809 b1809 +0.6 2.6 orf, hypothetical protein (VIMSS) compare
b1390 paaC +0.6 1.1 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation (NCBI) compare
b1418 cybB +0.6 1.9 cytochrome b(561) (VIMSS) compare
b3057 bacA +0.6 3.0 undecaprenyl pyrophosphate phosphatase (NCBI) compare
b1841 yobA +0.6 1.0 hypothetical protein (NCBI) compare
b1846 yebE +0.6 2.0 hypothetical protein (NCBI) compare
b2937 speB +0.6 2.8 agmatinase (NCBI) compare
b3775 ppiC +0.6 2.5 peptidyl-prolyl cis-trans isomerase C (rotamase C) (NCBI) compare
b0714 nei +0.6 2.7 endonuclease VIII/ 5-formyluracil/5-hydroxymethyluracil DNA glycosylase (NCBI) compare
b0862 artQ +0.6 1.3 arginine transporter subunit (NCBI) compare
b4634 ylcF +0.6 3.0 no description compare
b0114 aceE +0.6 1.0 pyruvate dehydrogenase subunit E1 (NCBI) compare
b4649 ysaD +0.6 1.3 no description compare
b3780 rhlB +0.6 3.8 ATP-dependent RNA helicase (NCBI) compare
b2195 ccmG +0.6 1.4 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b1270 btuR +0.6 2.0 cob(I)yrinic acid a,c-diamide adenosyltransferase (NCBI) compare
b2293 yfbT +0.6 0.9 putative phosphatase (VIMSS) compare
b1434 ydcN +0.6 0.7 predicted DNA-binding transcriptional regulator (NCBI) compare
b1427 rimL +0.6 1.3 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b1679 sufE +0.6 1.8 cysteine desufuration protein SufE (NCBI) compare
b2047 wcaJ +0.6 1.6 predicted UDP-glucose lipid carrier transferase (NCBI) compare
b3425 glpE +0.6 2.4 thiosulfate sulfurtransferase (NCBI) compare
b0880 cspD +0.6 1.0 cold shock protein homolog (NCBI) compare
b2510 b2510 +0.6 1.8 orf, hypothetical protein (VIMSS) compare
b0146 sfsA +0.6 3.3 sugar fermentation stimulation protein A (NCBI) compare
b4394 yjjX +0.6 1.7 orf, hypothetical protein (VIMSS) compare
b2058 wcaB +0.6 0.5 predicted acyl transferase (NCBI) compare


Specific Phenotypes

For 15 genes in this experiment

For stress Phenazine ethosulfate in Escherichia coli BW25113

For stress Phenazine ethosulfate across organisms