Experiment set10IT074 for Escherichia coli BW25113

Compare to:

LB, Anaerobic

200 most detrimental genes:

  gene name fitness t score description  
b1429 tehA +1.8 2.4 potassium-tellurite ethidium and proflavin transporter (NCBI) compare
b1217 chaB +1.7 2.7 cation transport regulator (NCBI) compare
b0564 appY +1.5 1.9 DLP12 prophage; DNA-binding transcriptional activator (NCBI) compare
b3658 selC +1.4 2.3 tRNA-Sec (NCBI) compare
b0464 acrR +1.3 7.4 DNA-binding transcriptional repressor (NCBI) compare
b0247 ykfG +1.3 2.5 CP4-6 prophage; predicted DNA repair protein (NCBI) compare
b4647 mokA +1.2 0.8 no description compare
b4246 pyrL +1.2 3.4 pyrBI operon leader peptide (NCBI) compare
b2289 lrhA +1.1 7.7 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes (NCBI) compare
b2279 nuoK +1.1 1.9 NADH dehydrogenase subunit K (NCBI) compare
b1248 b1248 +1.0 2.9 orf, hypothetical protein (VIMSS) compare
b2096 gatY +0.9 3.5 tagatose-bisphosphate aldolase 1 (VIMSS) compare
b4589 ylcI +0.9 2.2 hypothetical protein (RefSeq) compare
b1518 lsrG +0.9 2.3 autoinducer-2 (AI-2) modifying protein LsrG (NCBI) compare
b1185 dsbB +0.9 2.8 reoxidizes DsbA protein following formation of disulfide bond in P-ring of flagella. (VIMSS) compare
b1842 holE +0.9 1.7 DNA polymerase III, theta subunit (NCBI) compare
b2093 gatB +0.9 3.5 galactitol-specific enzyme IIB component of PTS (NCBI) compare
b1582 ynfA +0.9 2.3 hypothetical protein (NCBI) compare
b1103 ycfF +0.8 1.5 orf, hypothetical protein (VIMSS) compare
b4568 ytjA +0.8 2.3 predicted protein (RefSeq) compare
b4480 hdfR +0.8 3.9 transcriptional regulator HdfR (NCBI) compare
b0018 mokC +0.8 1.5 regulatory protein for HokC, overlaps CDS of hokC (NCBI) compare
b4413 sokC +0.8 1.7 regulatory antisense RNA (NCBI) compare
b2450 yffS +0.8 1.4 CPZ-55 prophage; predicted protein (RefSeq) compare
b2635 ypjK +0.8 2.6 CP4-57 prophage; predicted inner membrane protein (NCBI) compare
b1699 ydiS +0.7 2.7 predicted oxidoreductase with FAD/NAD(P)-binding domain (NCBI) compare
b0641 rlpB +0.7 2.0 minor lipoprotein (NCBI) compare
b2187 yejL +0.7 2.2 hypothetical protein (NCBI) compare
b3891 fdhE +0.7 4.4 formate dehydrogenase accessory protein FdhE (NCBI) compare
b2259 pmrD +0.7 0.8 polymyxin resistance protein B (VIMSS) compare
b1143 ymfI +0.7 1.1 orf, hypothetical protein (VIMSS) compare
b3590 selB +0.7 5.3 selenocysteinyl-tRNA-specific translation factor (NCBI) compare
b1540 ydfH +0.7 1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b2432 yfeY +0.7 1.7 hypothetical protein (NCBI) compare
b2236 yfaE +0.7 1.8 predicted 2Fe-2S cluster-containing protein (NCBI) compare
b0843 ybjH +0.7 1.8 hypothetical protein (NCBI) compare
b4431 rprA +0.7 1.3 Positive regulatory sRNA for RpoS translation; non-essential gene (RefSeq) compare
b2288 nuoA +0.6 1.9 NADH dehydrogenase I chain A (VIMSS) compare
b2317 dedA +0.6 2.5 conserved inner membrane protein (NCBI) compare
b2282 nuoH +0.6 2.0 NADH dehydrogenase subunit H (NCBI) compare
b1853 yebK +0.6 1.8 predicted DNA-binding transcriptional regulator (NCBI) compare
b3119 tdcR +0.6 1.8 threonine dehydratase operon activator protein (VIMSS) compare
b1263 trpD +0.6 1.7 bifunctional indole-3-glycerol-phosphate synthase/anthranilate phosphoribosyltransferase (NCBI) compare
b4158 yjeO +0.6 1.4 conserved inner membrane protein (NCBI) compare
b1266 yciV +0.6 2.1 hypothetical protein (NCBI) compare
b4695 ykgT +0.6 1.3 no description compare
b2953 yggU +0.6 1.5 orf, hypothetical protein (VIMSS) compare
b1804 rnd +0.6 2.4 ribonuclease D (NCBI) compare
b1613 manA +0.6 1.0 mannose-6-phosphate isomerase (VIMSS) compare
b1493 gadB +0.6 0.7 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b2198 ccmD +0.6 1.9 cytochrome c biogenesis protein (NCBI) compare
b2195 ccmG +0.6 1.5 periplasmic thioredoxin of cytochrome c-type biogenesis (NCBI) compare
b4438 cyaR +0.6 1.1 sRNA effector of ompX mRNA instability, cAMP-induced; hfq-dependent (RefSeq) compare
b3761 trpT +0.6 1.2 tRNA-Trp (NCBI) compare
b4241 treR +0.6 4.5 trehalose repressor (NCBI) compare
b1751 ydjY +0.6 1.9 orf, hypothetical protein (VIMSS) compare
b3860 dsbA +0.6 3.7 periplasmic protein disulfide isomerase I (NCBI) compare
b1575 dicB +0.6 0.8 Qin prophage; cell division inhibition protein (NCBI) compare
b2952 yggT +0.6 2.7 predicted inner membrane protein (NCBI) compare
b2911 ssrS +0.6 0.7 6S regulatory RNA (NCBI) compare
b1977 asnT +0.6 1.7 tRNA-Asn (NCBI) compare
b2058 wcaB +0.6 0.7 predicted acyl transferase (NCBI) compare
b1764 selD +0.5 2.1 selenophosphate synthetase (NCBI) compare
b3591 selA +0.5 3.9 selenocysteine synthase (NCBI) compare
b1904 yecR +0.5 1.4 hypothetical protein (NCBI) compare
b1607 ydgC +0.5 0.9 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b4532 yncN +0.5 1.4 orf, hypothetical protein (VIMSS) compare
b1289 ycjD +0.5 1.6 hypothetical protein (NCBI) compare
b0556 rzpD +0.5 1.8 DLP12 prophage; predicted murein endopeptidase (NCBI) compare
b1953 b1953 +0.5 1.3 orf, hypothetical protein (VIMSS) compare
b1247 oppF +0.5 2.0 oligopeptide transporter subunit (NCBI) compare
b1867 yecD +0.5 2.5 orf, hypothetical protein (VIMSS) compare
b2049 cpsB +0.5 2.2 mannose-1-phosphate guanyltransferase (NCBI) compare
b1234 rssA +0.5 2.1 conserved protein (RefSeq) compare
b0775 bioB +0.5 2.4 biotin synthase (NCBI) compare
b4386 lplA +0.5 3.3 lipoate-protein ligase A (NCBI) compare
b0974 hyaC +0.5 1.9 hydrogenase 1, b-type cytochrome subunit (NCBI) compare
b1307 pspD +0.5 1.2 peripheral inner membrane phage-shock protein (NCBI) compare
b2768 ygcP +0.5 1.9 predicted anti-terminator regulatory protein (NCBI) compare
b0195 yaeB +0.5 2.5 hypothetical protein (NCBI) compare
b1680 sufS +0.5 2.4 selenocysteine lyase (NCBI) compare
b0178 hlpA +0.5 1.3 periplasmic chaperone (NCBI) compare
b2954 yggV +0.5 2.4 putative deoxyribonucleotide triphosphate pyrophosphatase (NCBI) compare
b0365 tauA +0.5 2.4 taurine transport system periplasmic protein (VIMSS) compare
b2708 gutQ +0.5 2.5 orf, hypothetical protein (VIMSS) compare
b1282 yciH +0.5 2.2 orf, hypothetical protein (VIMSS) compare
b2476 purC +0.5 1.2 phosphoribosylaminoimidazole-succinocarboxamidesynthase (NCBI) compare
b1630 rsxD +0.5 2.4 electron transport complex protein RnfD (NCBI) compare
b0778 bioD +0.5 1.9 dethiobiotin synthetase (NCBI) compare
b4538 yoeF +0.5 0.9 hypothetical protein (RefSeq) compare
b2156 lysP +0.5 2.9 lysine transporter (NCBI) compare
b2193 narP +0.5 1.8 DNA-binding response regulator in two-component regulatory system with NarQ or NarX (NCBI) compare
b1310 ycjN +0.5 2.4 predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily (NCBI) compare
b2930 yggF +0.5 2.1 predicted hexoseP phosphatase (NCBI) compare
b1567 intK +0.5 1.2 Qin prophage; predicted protein (RefSeq) compare
b1434 ydcN +0.5 1.0 predicted DNA-binding transcriptional regulator (NCBI) compare
b1287 yciW +0.5 1.9 putative oxidoreductase (VIMSS) compare
b1358 ydaT +0.5 0.7 Rac prophage; predicted protein (NCBI) compare
b1812 pabB +0.5 2.1 para-aminobenzoate synthase component I (NCBI) compare
b1474 fdnG +0.5 2.4 formate dehydrogenase-N, alpha subunit, nitrate-inducible (NCBI) compare
b1987 cbl +0.5 2.5 DNA-binding transcriptional activator of cysteine biosynthesis (NCBI) compare
b0548 ninE +0.5 1.8 DLP12 prophage; conserved protein (NCBI) compare
b1443 ydcV +0.5 2.0 predicted spermidine/putrescine transporter subunit (NCBI) compare
b0889 lrp +0.5 1.6 DNA-binding transcriptional dual regulator, leucine-binding (NCBI) compare
b2614 grpE +0.5 1.0 heat shock protein (NCBI) compare
b1931 yedK +0.5 1.9 hypothetical protein (NCBI) compare
b0250 ykfB +0.5 1.5 CP4-6 prophage; predicted protein (NCBI) compare
b4533 ynfO +0.5 0.9 Qin prophage; predicted protein (NCBI) compare
b0336 codB +0.5 2.5 cytosine transporter (NCBI) compare
b0991 ymcE +0.5 1.6 cold shock gene (NCBI) compare
b1609 rstB +0.5 1.5 sensory histidine kinase in two-component regulatory system with RstA (NCBI) compare
b3775 ppiC +0.5 1.9 peptidyl-prolyl cis-trans isomerase C (rotamase C) (NCBI) compare
b1793 yoaF +0.5 1.4 conserved outer membrane protein (NCBI) compare
b3740 gidB +0.4 3.4 glucose-inhibited division protein B (NCBI) compare
b2023 hisH +0.4 2.1 imidazole glycerol phosphate synthase subunit HisH (NCBI) compare
b4301 sgcE +0.4 2.0 ribulose-phosphate 3-epimerase (NCBI) compare
b0487 cueR +0.4 1.3 DNA-binding transcriptional activator of copper-responsive regulon genes (NCBI) compare
b2617 smpA +0.4 1.2 small membrane protein A (VIMSS) compare
b3341 rpsG +0.4 0.6 30S ribosomal protein S7 (NCBI) compare
b0796 ybiH +0.4 1.4 putative transcriptional regulator (VIMSS) compare
b1394 paaG +0.4 1.0 enoyl-CoA hydratase (NCBI) compare
b2467 yffH +0.4 1.9 predicted NUDIX hydrolase (NCBI) compare
b3895 fdhD +0.4 2.1 formate dehydrogenase accessory protein (NCBI) compare
b2285 nuoE +0.4 1.0 NADH dehydrogenase subunit E (NCBI) compare
b0389 yaiA +0.4 1.2 hypothetical protein (NCBI) compare
b1765 ydjA +0.4 0.6 predicted oxidoreductase (NCBI) compare
b1581 rspA +0.4 1.4 predicted dehydratase (NCBI) compare
b4151 frdD +0.4 1.2 fumarate reductase subunit D (NCBI) compare
b1194 ycgR +0.4 1.3 protein involved in flagellar function (NCBI) compare
b2201 ccmA +0.4 2.1 ATP binding protein of heme exporter A (VIMSS) compare
b1278 pgpB +0.4 1.2 phosphatidylglycerophosphatase B (NCBI) compare
b1324 tpx +0.4 1.0 thiol peroxidase (NCBI) compare
b2094 gatA +0.4 2.1 galactitol-specific enzyme IIA component of PTS (NCBI) compare
b1013 ycdC +0.4 1.2 predicted DNA-binding transcriptional regulator (NCBI) compare
b1406 ydbC +0.4 2.3 predicted oxidoreductase, NAD(P)-binding (NCBI) compare
b4633 xisD +0.4 1.6 no description compare
b1593 b1593 +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b0220 ivy +0.4 1.5 inhibitor of vertebrate C-lysozyme (NCBI) compare
b0387 yaiI +0.4 1.5 orf, hypothetical protein (VIMSS) compare
b4450 arcZ +0.4 1.5 sRNA antisense regulator of tpx and sdaA, Hfq-dependent (RefSeq) compare
b1685 ydiH +0.4 0.8 predicted protein (RefSeq) compare
b4609 ryfD +0.4 1.4 Novel sRNA, function unknown (RefSeq) compare
b4157 yjeN +0.4 1.7 hypothetical protein (NCBI) compare
b0578 nfnB +0.4 2.1 dihydropteridine reductase, NAD(P)H-dependent, oxygen-insensitive (NCBI) compare
b2053 gmd +0.4 2.1 GDP-D-mannose dehydratase, NAD(P)-binding (NCBI) compare
b1349 recT +0.4 2.1 Rac prophage; recombination and repair protein (NCBI) compare
b2679 proX +0.4 1.4 glycine betaine transporter subunit (NCBI) compare
b1400 paaY +0.4 1.0 predicted hexapeptide repeat acetyltransferase (NCBI) compare
b3261 fis +0.4 0.7 DNA-binding protein Fis (NCBI) compare
b2800 fucA +0.4 2.3 L-fuculose phosphate aldolase (NCBI) compare
b4071 nrfB +0.4 1.2 formate-dependent nitrite reductase; a penta-haeme cytochrome c (VIMSS) compare
b0101 yacG +0.4 1.3 zinc-binding protein (NCBI) compare
b1296 ycjJ +0.4 1.4 putative amino acid/amine transport protein (VIMSS) compare
b3224 nanT +0.4 2.7 sialic acid transporter (VIMSS) compare
b0682 ybfN +0.4 1.7 predicted lipoprotein (NCBI) compare
b1035 ycdY +0.4 1.7 hypothetical protein (NCBI) compare
b0798 ybiA +0.4 0.9 hypothetical protein (NCBI) compare
b1427 rimL +0.4 0.7 ribosomal-protein-L7/L12-serine acetyltransferase (NCBI) compare
b1777 b1777 +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b0248 yafX +0.4 1.4 CP4-6 prophage; predicted protein (NCBI) compare
b2480 bcp +0.4 1.9 thioredoxin-dependent thiol peroxidase (NCBI) compare
b2674 nrdI +0.4 1.4 hypothetical protein (NCBI) compare
b1522 yneF +0.4 1.7 predicted diguanylate cyclase (NCBI) compare
b0579 ybdF +0.4 1.4 hypothetical protein (NCBI) compare
b4578 insP +0.4 0.7 no description compare
b1161 ycgX +0.4 0.4 hypothetical protein (NCBI) compare
b0632 dacA +0.4 2.3 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) (NCBI) compare
b1591 b1591 +0.4 0.9 putative oxidoreductase component (VIMSS) compare
b2946 yggJ +0.4 2.0 orf, hypothetical protein (VIMSS) compare
b1858 znuC +0.4 1.9 high-affinity zinc transporter ATPase (NCBI) compare
b2095 gatZ +0.4 2.3 D-tagatose 1,6-bisphosphate aldolase 2, subunit (NCBI) compare
b1767 ansA +0.4 1.6 cytoplasmic asparaginase I (NCBI) compare
b1639 ydhA +0.4 1.6 orf, hypothetical protein (VIMSS) compare
b1902 yecI +0.4 1.5 predicted ferritin-like protein (NCBI) compare
b1004 wrbA +0.4 1.7 TrpR binding protein WrbA (NCBI) compare
b2293 yfbT +0.4 0.6 putative phosphatase (VIMSS) compare
b4458 oxyS +0.4 0.6 global regulatory RNA (NCBI) compare
b2300 yfcE +0.4 1.1 orf, hypothetical protein (VIMSS) compare
b1971 yedY +0.4 1.5 hypothetical protein (NCBI) compare
b4403 yjtD +0.4 1.8 predicted rRNA methyltransferase (NCBI) compare
b0212 gloB +0.4 1.1 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b4277 yjgZ +0.4 1.7 KpLE2 phage-like element; predicted protein (NCBI) compare
b1150 ymfR +0.4 0.5 e14 prophage; predicted protein (NCBI) compare
b0225 yafQ +0.4 1.0 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b0951 pqiB +0.4 2.0 paraquat-inducible protein B (NCBI) compare
b4292 fecR +0.4 2.2 KpLE2 phage-like element; transmembrane signal transducer for ferric citrate transport (NCBI) compare
b0814 ompX +0.4 1.3 outer membrane protein X (NCBI) compare
b1283 osmB +0.4 2.2 lipoprotein (NCBI) compare
b4418 sraB +0.4 0.6 unknown RNA (NCBI) compare
b1595 ynfL +0.4 0.9 predicted DNA-binding transcriptional regulator (NCBI) compare
b3573 yiaI +0.4 1.7 predicted hydrogenase, 4Fe-4S ferredoxin-type component (NCBI) compare
b1874 cutC +0.4 0.7 copper homeostasis protein (NCBI) compare
b1135 ymfC +0.4 1.7 orf, hypothetical protein (VIMSS) compare
b4521 ycgI +0.4 1.1 hypothetical protein (NCBI) compare
b4572 ylbE +0.4 1.7 no description compare
b1841 yobA +0.4 0.7 hypothetical protein (NCBI) compare
b0504 ybbS +0.4 1.3 DNA-binding transcriptional activator of the allD operon (NCBI) compare
b3382 yhfY +0.4 1.7 orf, hypothetical protein (VIMSS) compare
b1660 ydhC +0.4 1.3 predicted transporter (NCBI) compare
b0518 fdrA +0.4 2.1 membrane protein FdrA (NCBI) compare


Specific Phenotypes

None in this experiment

For Escherichia coli BW25113 in lb experiments