Experiment set10IT071 for Escherichia coli BW25113

Compare to:

LB Anaerobic with Norfloxacin 0.00000015625 mM

200 most important genes:

  gene name fitness t score description  
b4201 priB -4.6 -3.1 primosomal replication protein N (NCBI) compare
b3035 tolC -3.7 -8.6 outer membrane channel; specific tolerance to colicin E1; segregation of daughter chromosomes (VIMSS) compare
b0463 acrA -3.2 -11.1 multidrug efflux system (NCBI) compare
b0462 acrB -3.2 -16.7 multidrug efflux system protein (NCBI) compare
b1334 fnr -3.0 -2.9 DNA-binding transcriptional dual regulator, global regulator of anaerobic growth (NCBI) compare
b1361 ydaW -2.9 -1.5 orf, hypothetical protein (VIMSS) compare
b2528 iscA -2.7 -2.4 iron-sulfur cluster assembly protein (NCBI) compare
b2509 xseA -2.5 -8.6 exodeoxyribonuclease VII large subunit (NCBI) compare
b3390 aroK -2.4 -2.3 shikimate kinase I (NCBI) compare
b1575 dicB -2.4 -2.2 Qin prophage; cell division inhibition protein (NCBI) compare
b1863 ruvC -2.3 -1.6 Holliday junction resolvase (NCBI) compare
b3163 nlpI -2.3 -4.8 hypothetical protein (NCBI) compare
b1765 ydjA -2.1 -1.5 predicted oxidoreductase (NCBI) compare
b4701 sokX -2.1 -1.4 sok-related sRNA, function unknown (RefSeq) compare
b1286 rnb -2.1 -2.4 exoribonuclease II (NCBI) compare
b3042 b3042 -2.0 -3.7 orf, hypothetical protein (VIMSS) compare
b3792 wzxE -2.0 -6.5 O-antigen translocase (NCBI) compare
b0912 ihfB -2.0 -3.7 integration host factor subunit beta (NCBI) compare
b0990 cspG -2.0 -1.8 DNA-binding transcriptional regulator (NCBI) compare
b0212 gloB -2.0 -2.8 predicted hydroxyacylglutathione hydrolase (NCBI) compare
b0729 sucD -1.9 -3.4 succinyl-CoA synthetase subunit alpha (NCBI) compare
b1882 cheY -1.8 -0.9 chemotaxis regulator transmitting signal to flagellar motor component (NCBI) compare
b3652 recG -1.7 -8.0 ATP-dependent DNA helicase (NCBI) compare
b4238 nrdD -1.7 -11.4 anaerobic ribonucleoside triphosphate reductase (NCBI) compare
b1150 ymfR -1.7 -1.2 e14 prophage; predicted protein (NCBI) compare
b0728 sucC -1.7 -6.0 succinyl-CoA synthetase subunit beta (NCBI) compare
b4237 nrdG -1.7 -6.8 anaerobic ribonucleotide reductase activating protein (NCBI) compare
b4592 yccB -1.6 -2.1 hypothetical protein (RefSeq) compare
b2616 recN -1.6 -8.1 recombination and repair protein (NCBI) compare
b1936 intG -1.6 -1.0 predicted defective phage integrase (pseudogene) (RefSeq) compare
b0902 pflA -1.6 -6.1 pyruvate formate lyase activating enzyme 1 (NCBI) compare
b1861 ruvA -1.5 -1.0 Holliday junction DNA helicase motor protein (NCBI) compare
b1291 sapD -1.4 -1.6 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3868 glnG -1.4 -4.1 fused DNA-binding response regulator in two-component regulatory system with GlnL: response regulator/sigma54 interaction protein (NCBI) compare
b2637 yfjT -1.4 -2.9 CP4-57 prophage; predicted protein (NCBI) compare
b2215 ompC -1.3 -6.5 outer membrane porin protein C (NCBI) compare
b0730 mngR -1.3 -1.2 DNA-binding transcriptional dual regulator, fatty-acyl-binding (NCBI) compare
b4480 hdfR -1.3 -4.5 transcriptional regulator HdfR (NCBI) compare
b4025 pgi -1.2 -5.5 glucose-6-phosphate isomerase (NCBI) compare
b3935 priA -1.2 -2.5 primosome assembly protein PriA (NCBI) compare
b2258 b2258 -1.2 -1.4 putative transport/receptor protein (VIMSS) compare
b4535 yniD -1.2 -1.3 predicted protein (RefSeq) compare
b2567 rnc -1.2 -0.8 ribonuclease III (NCBI) compare
b3813 uvrD -1.2 -8.0 DNA-dependent ATPase I and helicase II (NCBI) compare
b1730 ydjO -1.1 -0.7 predicted protein (RefSeq) compare
b2894 xerD -1.1 -0.7 site-specific tyrosine recombinase XerD (NCBI) compare
b3930 menA -1.1 -8.2 1,4-dihydroxy-2-naphthoate octaprenyltransferase (NCBI) compare
b3838 tatB -1.1 -4.3 sec-independent translocase (NCBI) compare
b4520 ymgF -1.1 -1.4 hypothetical protein (NCBI) compare
b1969 yedW -1.1 -2.8 putative 2-component transcriptional regulator (VIMSS) compare
b3261 fis -1.1 -0.7 DNA-binding protein Fis (NCBI) compare
b1536 ydeI -1.1 -0.7 hypothetical protein (NCBI) compare
b0149 mrcB -1.1 -7.4 penicillin-binding protein 1b (NCBI) compare
b1824 yobF -1.1 -2.5 hypothetical protein (NCBI) compare
b3199 yrbK -1.1 -2.2 hypothetical protein (NCBI) compare
b1663 mdtK -1.1 -4.2 multidrug efflux protein NorM (NCBI) compare
b2433 b2433 -1.1 -2.3 orf, hypothetical protein (VIMSS) compare
b1480 sra -1.1 -1.3 30S ribosomal subunit protein S22 (NCBI) compare
b4695 ykgT -1.1 -1.1 no description compare
b2820 recB -1.1 -0.7 exonuclease V (RecBCD complex), beta subunit (NCBI) compare
b4679 yohP -1.1 -2.2 expressed protein (RefSeq) compare
b0232 yafN -1.1 -0.7 predicted antitoxin of the YafO-YafN toxin-antitoxin system (NCBI) compare
b0487 cueR -1.1 -2.0 DNA-binding transcriptional activator of copper-responsive regulon genes (NCBI) compare
b1951 rcsA -1.0 -0.7 DNA-binding transcriptional activator, co-regulator with RcsB (NCBI) compare
b4435 isrC -1.0 -1.8 unknown RNA (NCBI) compare
b1600 mdtJ -1.0 -1.5 multidrug efflux system transporter (NCBI) compare
b4653 yicT -1.0 -1.9 no description compare
b1306 pspC -1.0 -2.4 DNA-binding transcriptional activator (NCBI) compare
b4191 ulaR -1.0 -2.9 DNA-binding transcriptional dual regulator (NCBI) compare
b1175 minD -1.0 -3.3 membrane ATPase of the MinC-MinD-MinE system (NCBI) compare
b0949 uup -1.0 -5.1 fused predicted transporter subunits of ABC superfamily: ATP-binding components (NCBI) compare
b0783 moaC -1.0 -3.8 molybdenum cofactor biosynthesis protein C (NCBI) compare
b1634 tppB -1.0 -3.7 putative tripeptide transporter permease (NCBI) compare
b1252 tonB -1.0 -2.3 membrane spanning protein in TonB-ExbB-ExbD complex (NCBI) compare
b1984 asnW -1.0 -1.1 tRNA-Asn (NCBI) compare
b1567 intK -1.0 -1.9 Qin prophage; predicted protein (RefSeq) compare
b0145 dksA -1.0 -1.8 DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein (NCBI) compare
b3148 yraN -1.0 -3.0 hypothetical protein (NCBI) compare
b1192 ldcA -1.0 -3.2 L,D-carboxypeptidase A (NCBI) compare
b0799 dinG -1.0 -5.3 ATP-dependent DNA helicase (NCBI) compare
b0765 modC -1.0 -3.4 molybdate transporter subunit (NCBI) compare
b1164 ycgZ -1.0 -1.1 hypothetical protein (NCBI) compare
b1370 insH-5 -1.0 -2.0 Rac prophage; IS5 transposase and trans-activator (NCBI) compare
b1671 ydhX -1.0 -1.8 predicted 4Fe-4S ferridoxin-type protein (RefSeq) compare
b2450 yffS -1.0 -1.4 CPZ-55 prophage; predicted protein (RefSeq) compare
b1961 dcm -1.0 -1.4 DNA cytosine methylase (NCBI) compare
b3870 glnA -0.9 -1.8 glutamine synthetase (NCBI) compare
b0009 mog -0.9 -4.9 molybdenum cofactor biosynthesis protein (NCBI) compare
b3260 dusB -0.9 -3.5 tRNA-dihydrouridine synthase B (NCBI) compare
b1101 ptsG -0.9 -5.0 fused glucose-specific PTS enzymes: IIB component/IIC component (NCBI) compare
b0903 pflB -0.9 -5.3 pyruvate formate lyase I (NCBI) compare
b1726 yniB -0.9 -1.7 predicted inner membrane protein (NCBI) compare
b4640 yoeG -0.9 -1.3 no description compare
b2699 recA -0.9 -0.6 recombinase A (NCBI) compare
b1579 intQ -0.9 -1.7 Qin prophage; predicted defective integrase (RefSeq) compare
b2698 recX -0.9 -1.9 RecA regulator RecX (NCBI) compare
b0014 dnaK -0.9 -1.2 molecular chaperone DnaK (NCBI) compare
b1860 ruvB -0.8 -0.5 Holliday junction DNA helicase B (NCBI) compare
b1551 b1551 -0.8 -0.5 orf, hypothetical protein (VIMSS) compare
b1196 ycgY -0.8 -1.2 hypothetical protein (NCBI) compare
b1877 yecT -0.8 -0.9 orf, hypothetical protein (VIMSS) compare
b2822 recC -0.8 -2.4 exonuclease V (RecBCD complex), gamma chain (NCBI) compare
b4579 yaiX -0.8 -2.7 no description compare
b0364 yaiS -0.8 -1.9 orf, hypothetical protein (VIMSS) compare
b1171 b1171 -0.8 -1.4 orf, hypothetical protein (VIMSS) compare
b0053 surA -0.8 -3.2 peptidyl-prolyl cis-trans isomerase (PPIase) (NCBI) compare
b1493 gadB -0.8 -0.7 glutamate decarboxylase B, PLP-dependent (NCBI) compare
b0781 moaA -0.8 -4.6 molybdenum cofactor biosynthesis protein A (NCBI) compare
b0051 ksgA -0.8 -2.2 dimethyladenosine transferase (NCBI) compare
b2110 yehC -0.8 -0.7 predicted periplasmic pilin chaperone (NCBI) compare
b0785 moaE -0.8 -2.6 molybdopterin synthase, large subunit (NCBI) compare
b2329 aroC -0.8 -3.1 chorismate synthase (NCBI) compare
b3443 yrhA -0.8 -1.0 orf, hypothetical protein (VIMSS) compare
b4494 arpB -0.8 -0.7 no description compare
b4523 yciX -0.8 -2.8 hypothetical protein (RefSeq) compare
b1067 yceH -0.8 -2.6 hypothetical protein (NCBI) compare
b4146 yjeK -0.8 -0.9 predicted lysine aminomutase (NCBI) compare
b0605 ahpC -0.8 -2.1 alkyl hydroperoxide reductase, C22 subunit (NCBI) compare
b1848 yebG -0.8 -1.1 conserved protein regulated by LexA (NCBI) compare
b1409 ynbB -0.8 -0.7 predicted CDP-diglyceride synthase (NCBI) compare
b1742 b1742 -0.8 -1.5 orf, hypothetical protein (VIMSS) compare
b0683 fur -0.7 -0.9 ferric uptake regulator (NCBI) compare
b4603 rseX -0.7 -0.6 sRNA regulating ompA and ompC translation, with Hfq (RefSeq) compare
b2892 recJ -0.7 -4.3 ssDNA exonuclease, 5' --> 3'-specific (NCBI) compare
b4341 yjiS -0.7 -2.4 hypothetical protein (NCBI) compare
b0764 modB -0.7 -2.3 molybdate ABC transporter permease protein (NCBI) compare
b1124 potC -0.7 -2.7 spermidine/putrescine ABC transporter membrane protein (NCBI) compare
b3629 rfaS -0.7 -1.3 lipopolysaccharide core biosynthesis protein (NCBI) compare
b3839 tatC -0.7 -3.4 TatABCE protein translocation system subunit (NCBI) compare
b1346 ydaQ -0.7 -0.9 orf, hypothetical protein (VIMSS) compare
b3764 yifE -0.7 -1.8 hypothetical protein (NCBI) compare
b0499 ylbH -0.7 -2.0 conserved protein, rhs-like (RefSeq) compare
b1497 b1497 -0.7 -0.4 putative enzyme (VIMSS) compare
b1499 ydeO -0.7 -0.3 predicted DNA-binding transcriptional acfivator (NCBI) compare
b3869 glnL -0.7 -4.2 sensory histidine kinase in two-component regulatory system with GlnG (NCBI) compare
b1607 ydgC -0.7 -0.9 conserved inner membrane protein associated with alginate biosynthesis (NCBI) compare
b2111 yehD -0.7 -1.5 predicted fimbrial-like adhesin protein (NCBI) compare
b1309 ycjM -0.7 -2.0 putative polysaccharide hydrolase (VIMSS) compare
b0763 modA -0.7 -1.9 molybdate transporter subunit (NCBI) compare
b2165 yeiN -0.7 -2.7 hypothetical protein (NCBI) compare
b1712 ihfA -0.7 -0.6 integration host factor subunit alpha (NCBI) compare
b3096 yqjB -0.7 -3.4 hypothetical protein (NCBI) compare
b1505 ydeT -0.7 -0.7 hypothetical protein (RefSeq) compare
b4375 prfC -0.7 -1.8 peptide chain release factor 3 (NCBI) compare
b1363 trkG -0.7 -0.4 Rac prophage; potassium transporter subunit (NCBI) compare
b1290 sapF -0.7 -0.9 predicted antimicrobial peptide transporter subunit (NCBI) compare
b1785 yeaI -0.7 -1.2 predicted diguanylate cyclase (NCBI) compare
b3644 yicC -0.7 -2.7 hypothetical protein (NCBI) compare
b3672 ivbL -0.7 -2.3 ilvB operon leader peptide (NCBI) compare
b3928 yiiU -0.7 -3.4 hypothetical protein (NCBI) compare
b0696 kdpC -0.7 -1.6 potassium-transporting ATPase subunit C (NCBI) compare
b1696 ydiP -0.7 -1.3 predicted DNA-binding transcriptional regulator (NCBI) compare
b1545 pinQ -0.7 -0.3 Qin prophage; predicted site-specific recombinase (NCBI) compare
b1302 puuE -0.7 -1.9 GABA aminotransferase, PLP-dependent (NCBI) compare
b1690 ydiM -0.7 -0.8 predicted transporter (NCBI) compare
b2471 yffB -0.7 -2.1 hypothetical protein (NCBI) compare
b2278 nuoL -0.7 -3.9 NADH dehydrogenase subunit L (NCBI) compare
b1531 marA -0.7 -1.2 multiple antibiotic resistance; transcriptional activator of defense systems (VIMSS) compare
b1968 yedV -0.7 -1.2 predicted sensory kinase in two-component regulatory system with YedW (NCBI) compare
b1576 ydfD -0.7 -0.3 Qin prophage; predicted protein (NCBI) compare
b1235 rssB -0.7 -3.3 response regulator of RpoS (NCBI) compare
b2991 hybF -0.7 -2.4 protein involved with the maturation of hydrogenases 1 and 2 (NCBI) compare
b3766 ilvL -0.6 -2.0 ilvG operon leader peptide (NCBI) compare
b1351 racC -0.6 -0.3 Rac prophage; predicted protein (NCBI) compare
b1013 ycdC -0.6 -1.6 predicted DNA-binding transcriptional regulator (NCBI) compare
b1514 lsrC -0.6 -1.4 AI2 transporter (NCBI) compare
b0740 tolB -0.6 -2.0 translocation protein TolB precursor (NCBI) compare
b4389 radA -0.6 -3.7 predicted repair protein (NCBI) compare
b1347 ydaC -0.6 -0.3 Rac prophage; predicted protein (NCBI) compare
b1307 pspD -0.6 -1.1 peripheral inner membrane phage-shock protein (NCBI) compare
b4000 hupA -0.6 -2.1 HU, DNA-binding transcriptional regulator, alpha subunit (NCBI) compare
b0239 frsA -0.6 -3.9 fermentation/respiration switch protein (NCBI) compare
b3626 rfaJ -0.6 -1.5 UDP-D-glucose:(galactosyl)lipopolysaccharide glucosyltransferase (NCBI) compare
b3484 yhhI -0.6 -1.4 predicted transposase (NCBI) compare
b2629 yfjM -0.6 -1.7 CP4-57 prophage; predicted protein (NCBI) compare
b2997 hybO -0.6 -3.1 hydrogenase 2, small subunit (NCBI) compare
b0430 cyoC -0.6 -2.0 cytochrome o ubiquinol oxidase subunit III (NCBI) compare
b3354 yheU -0.6 -2.8 hypothetical protein (NCBI) compare
b2398 yfeC -0.6 -0.9 orf, hypothetical protein (VIMSS) compare
b0989 cspH -0.6 -0.8 stress protein, member of the CspA-family (NCBI) compare
b2553 glnB -0.6 -2.0 regulatory protein P-II for glutamine synthetase (NCBI) compare
b2896 ygfX -0.6 -2.3 hypothetical protein (NCBI) compare
b4100 phnH -0.6 -1.7 carbon-phosphorus lyase complex subunit (NCBI) compare
b0804 ybiX -0.6 -2.3 putative enzyme (VIMSS) compare
b4497 yeeL -0.6 -0.4 no description compare
b4513 kdpF -0.6 -1.1 potassium ion accessory transporter subunit (NCBI) compare
b1109 ndh -0.6 -1.5 respiratory NADH dehydrogenase 2/cupric reductase (NCBI) compare
b0225 yafQ -0.6 -1.6 predicted toxin of the YafQ-DinJ toxin-antitoxin system (NCBI) compare
b1163 ycgF -0.6 -1.8 predicted FAD-binding phosphodiesterase (NCBI) compare
b0761 modE -0.6 -3.0 DNA-binding transcriptional dual regulator (NCBI) compare
b4538 yoeF -0.6 -0.9 hypothetical protein (RefSeq) compare
b4543 ypaA -0.6 -1.5 predicted protein (NCBI) compare
b4239 treC -0.6 -1.0 trehalose-6-P hydrolase (NCBI) compare
b4215 ytfI -0.6 -0.4 hypothetical protein (NCBI) compare
b0968 yccX -0.6 -1.6 predicted acylphosphatase (NCBI) compare
b2494 yfgC -0.6 -3.0 predicted peptidase (NCBI) compare
b0483 ybaQ -0.6 -2.5 orf, hypothetical protein (VIMSS) compare
b1293 sapB -0.6 -0.8 predicted antimicrobial peptide transporter subunit (NCBI) compare
b3247 cafA -0.6 -3.7 bundles of cytoplasmic filaments (VIMSS) compare
b4184 yjfL -0.6 -1.6 conserved inner membrane protein (NCBI) compare


Specific Phenotypes

For 4 genes in this experiment

For stress Norfloxacin in Escherichia coli BW25113

For stress Norfloxacin across organisms