Protein Info for MPMX19_03460 in Azospirillum sp. SherDot2

Annotation: Signal transduction histidine-protein kinase AtoS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 620 transmembrane" amino acids 20 to 38 (19 residues), see Phobius details amino acids 167 to 186 (20 residues), see Phobius details amino acids 204 to 224 (21 residues), see Phobius details PF13188: PAS_8" amino acids 278 to 321 (44 residues), 22.9 bits, see alignment 1.9e-08 TIGR00229: PAS domain S-box protein" amino acids 278 to 392 (115 residues), 47.2 bits, see alignment E=1.2e-16 PF00989: PAS" amino acids 278 to 383 (106 residues), 57.4 bits, see alignment E=4.2e-19 PF08448: PAS_4" amino acids 281 to 389 (109 residues), 49.1 bits, see alignment E=1.9e-16 PF13426: PAS_9" amino acids 286 to 386 (101 residues), 40 bits, see alignment E=1.2e-13 PF00512: HisKA" amino acids 403 to 464 (62 residues), 55.2 bits, see alignment E=1.8e-18 PF02518: HATPase_c" amino acids 507 to 612 (106 residues), 91.6 bits, see alignment E=1.4e-29

Best Hits

KEGG orthology group: K07710, two-component system, NtrC family, sensor histidine kinase AtoS [EC: 2.7.13.3] (inferred from 64% identity to rpc:RPC_0828)

Predicted SEED Role

"Sensory histidine kinase AtoS" in subsystem Orphan regulatory proteins

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (620 amino acids)

>MPMX19_03460 Signal transduction histidine-protein kinase AtoS (Azospirillum sp. SherDot2)
MWHLDWIRRSLPSTLRGKLLLVSLAVVVLPISLTGYLLEREGRQALVREKSEKLFGLTRL
LDAHLGPGFDSLLTDAGVDAAVAAGDRDAAIRVLSGRLTPFTDMIAGANPGVGVGYYSKA
LNTIITYGPSRDYSATVGTTIPPEHPGWHVLESGKQALESGRQVRGFILNAMLPILRDGG
VIGYIWANELSDDVERQAAAMDRAVLTVSLGGILLGLVLTQVLTRGVGRDIRQIIDGLLR
MRSDLGDAIRPPPGEVGAIAVEVNAMARALLDAKSLTENILHSIADGVIAVDRAGQVTAL
NPAAEAMIGVNATEVIGRPYESLFKPDGRFASPLLDTLKTGRQHVGVALDFPGTRQTLHL
TVSSSVLRDSHGEAIGAVVVLKDLTEQQRLRTQIMRADRLAALGELVAGLAHEVRNPLTS
IRGFMQFLESSDDVAEWQRYAPLIVRQVDSLNRLVTELLEFGRPRPPAFLPVQLNDLIRE
VSLLAGRKSNARIALHPAPDLPLAEADGEALKQVMLNLIINAVQATSETGGIAIATAMAA
DGREAVITVSDDGEGIAPENLDKVFDPFFSTKPQGTGLGLAMAHRIVDAHHGTIAIASVP
GAGTTVTLRIPILHNRAVDA