Protein Info for MPMX19_02522 in Azospirillum sp. SherDot2

Annotation: Translation initiation factor IF-2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 961 PF08364: IF2_assoc" amino acids 30 to 53 (24 residues), 29.1 bits, see alignment (E = 4.2e-10) TIGR00487: translation initiation factor IF-2" amino acids 375 to 959 (585 residues), 813.7 bits, see alignment E=1.1e-248 PF04760: IF2_N" amino acids 383 to 432 (50 residues), 59.2 bits, see alignment 1.2e-19 TIGR00231: small GTP-binding protein domain" amino acids 461 to 611 (151 residues), 109.9 bits, see alignment E=1.1e-35 PF00009: GTP_EFTU" amino acids 463 to 619 (157 residues), 117.7 bits, see alignment E=2.2e-37 PF01926: MMR_HSR1" amino acids 463 to 569 (107 residues), 43.8 bits, see alignment E=1.1e-14 PF00071: Ras" amino acids 464 to 617 (154 residues), 23.3 bits, see alignment E=2e-08 PF22042: EF-G_D2" amino acids 635 to 714 (80 residues), 95.6 bits, see alignment E=7e-31 PF11987: IF-2" amino acids 736 to 851 (116 residues), 147.9 bits, see alignment E=5.4e-47 PF03144: GTP_EFTU_D2" amino acids 882 to 949 (68 residues), 35.8 bits, see alignment 3.9e-12

Best Hits

Swiss-Prot: 66% identical to IF2_MAGSA: Translation initiation factor IF-2 (infB) from Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 94% identity to azl:AZL_028590)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (961 amino acids)

>MPMX19_02522 Translation initiation factor IF-2 (Azospirillum sp. SherDot2)
MTDSNDQDQKKVLHLTGASKGKLESKKPVETQVRQSFSHGRSKAVTVEVKRKRHVEKGAV
PGVADGGAAARQAAQGLPMRGAQGQRPRGGGAPAGRQLTREELESRLRALRGAAAFEEQR
RIDAEEEVARAEARAAEAEARAAQAAEDEAAAPAAPSEAAAPAAAAAPSDAPAPAAPEMP
PIILDADTLRQRELDEMRAIQEEDRKIAAEAERRRKEEEAKRKEAEDAKRRDAEPAPRRD
GARDGARDGAGRDGARPVGARPAGDQRPGGPAARPAADAAPGRPQPGVGAPPARAEEEDD
NRRKGGRGGAPAKAAPARPAAKAPAGADRRKGTKLTVSQALSDDGSDRTRSLAAVRRARE
RERLRQMSRQETAKVTRDVVLPEVITVQELANRMAERGADVIKALMRMGVMATINQTIDA
DTAELLITEFGHRVRRVSESDVEIGLRATEEEGAVLVPRPPVVTIMGHVDHGKTSLLDAL
RQTDVVSGEAGGITQHIGAYQVQLESGAKITFIDTPGHAAFTEMRARGANVTDVVVLVVA
ANDGVMPQTIEAIRHAKAAKVPIIVAINKCDLPDAKPERVRQELLQHELVVEEMGGDVLD
VEVSAKAKRNLSKLEEAILLQAEILELRANPERAAEGVVIEAKLERGRGSVATVLVQRGT
LKVGDVFVTGAEWGRVRALINDRGQNVNEAAPAVPVEVLGLNGTPMAGDDFSVVESEARA
REIAEFRQRKKREAAVAASARGSLQDMFSRIQAGEAKELPVVIKGDVQGSIEAIASSLEK
LTAENTEVKVRVLHNSVGAINESDITLANASNAMIIGFNVRANPQARDLAKRDGVEIRYY
SIIYNVIDDVKAALTGLLSPTLRERFIGYATIREVFNITKVGKVAGCMVTQGTVKRGAGV
RLLRDNVVIHEGTLKTLKRFKDEVKDVREGYECGMAFENYDNIQAGDQIEAFEIDEIARE
L