Protein Info for MPMX19_00187 in Azospirillum sp. SherDot2

Annotation: Methionine aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00500: methionine aminopeptidase, type I
  • amino acids 1 to 235 (235 residues), 301.7 bits, E=2e-94
• PF00557: Peptidase_M24
  • amino acids 1 to 226 (226 residues), 175.2 bits, E=7.8e-56

Best Hits

Swiss-Prot: 63% identical to MAP1_RICPR: Methionine aminopeptidase (map) from Rickettsia prowazekii (strain Madrid E)

KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 97% identity to azl:AZL_025320)

MetaCyc: 54% identical to methionine aminopeptidase (Escherichia coli K-12 substr. MG1655)
Methionyl aminopeptidase. [EC: 3.4.11.18]

Predicted SEED Role

"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)

MetaCyc Pathways

• Arg/N-end rule pathway (eukaryotic) (8/14 steps found)
• Ac/N-end rule pathway (6/21 steps found)

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.18

Use Curated BLAST to search for 3.4.11.18

Protein Sequence (248 amino acids)

>MPMX19_00187 Methionine aminopeptidase (Azospirillum sp. SherDot2)
MRKAGRLAALALDYIVPYVQPGVTTGELDRLLEQFIRDHGGIPAPLGYRGFPRANCISVN
HVVCHGIPGDKRLVDGDILNIDVTPIVDGWYGDSSRMYLCGDVGVKARKLVDVTYDALMI
GIAAVKPGATLGDIGHAIQTFAESHRFSVVRDFCGHGVGRVFHEPPSVLHYGKPGEGLVL
REGMIFTIEPMINTGRPDVKILGDGWTAVTKDKSLSAQFEHSIGVTADGAEIFTLSPAGY
TKPPYPVE