Protein Info for EX28DRAFT_3749 in Enterobacter asburiae PDN3

Annotation: deoxyguanosinetriphosphate triphosphohydrolase, putative

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 504 TIGR01353: putative dGTPase" amino acids 30 to 501 (472 residues), 469.2 bits, see alignment E=7.8e-145 PF01966: HD" amino acids 66 to 134 (69 residues), 30.8 bits, see alignment E=3.2e-11

Best Hits

Swiss-Prot: 91% identical to DGTP_ENT38: Deoxyguanosinetriphosphate triphosphohydrolase (dgt) from Enterobacter sp. (strain 638)

KEGG orthology group: K01129, dGTPase [EC: 3.1.5.1] (inferred from 95% identity to enc:ECL_00964)

MetaCyc: 85% identical to dGTP triphosphohydrolase (Escherichia coli K-12 substr. MG1655)
dGTPase. [EC: 3.1.5.1]

Predicted SEED Role

"Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1)" in subsystem Purine conversions (EC 3.1.5.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.5.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (504 amino acids)

>EX28DRAFT_3749 deoxyguanosinetriphosphate triphosphohydrolase, putative (Enterobacter asburiae PDN3)
MAPIDFRTKINWHRRFRSPQGDKSEHEILRIFESDRGRIVNSPAIRRLQQKTQVFPLERN
AAVRTRLTHSMEVQQVGRYIAKEILSRLKEQRLLEAYGLDELTGPFESIVEMACLMHDIG
NPPFGHFGEAAINDWFKQRLYPSDAVSQPLSDDRCIVRDLRLREGEERLNDLRRKVRQDL
CHFEGNAQGIRLVHSLMRMNLTWAQVGCILKYTRPAWWIGDTPASHSYLMKKPGYYLSEE
AYIERLRKELSLTPNGRFPLTWIMEAADDISYCVADLEDAVEKRIFSVEELYQHLYAAWG
THEKGSLFAQVVENAWEKSRSNTLSRSTEDQFFMYLRVNTLNKLVPYAASRFIDNLPLIF
SGEFNHALLEDDSSFSQLLELYKHVAMRHVFSHPDVEQLELQGYRVISGLLEIYSPLLRL
SVDEFSELVEHERVRRIPIESRLYQKLSTRHRLAYVEAIGKLERNSPEWPVMEYYYRCRL
IQDYISGMTDLYAWDEYRKLMAVE