Protein Info for EX28DRAFT_1741 in Enterobacter asburiae PDN3

Annotation: phosphotransferase system, cellobiose specific, IIC component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 transmembrane" amino acids 35 to 55 (21 residues), see Phobius details amino acids 86 to 107 (22 residues), see Phobius details amino acids 114 to 133 (20 residues), see Phobius details amino acids 145 to 167 (23 residues), see Phobius details amino acids 187 to 207 (21 residues), see Phobius details amino acids 227 to 267 (41 residues), see Phobius details amino acids 300 to 321 (22 residues), see Phobius details amino acids 341 to 352 (12 residues), see Phobius details amino acids 356 to 381 (26 residues), see Phobius details amino acids 400 to 400 (1 residues), see Phobius details amino acids 405 to 426 (22 residues), see Phobius details TIGR00359: PTS system, cellobiose-specific IIC component" amino acids 12 to 439 (428 residues), 553.8 bits, see alignment E=2.9e-170 TIGR00410: PTS system, lactose/cellobiose family IIC component" amino acids 12 to 439 (428 residues), 553.8 bits, see alignment E=2.9e-170 PF02378: PTS_EIIC" amino acids 30 to 363 (334 residues), 153.6 bits, see alignment E=3.4e-49

Best Hits

Swiss-Prot: 90% identical to PTQC_ECOLI: PTS system N,N'-diacetylchitobiose-specific EIIC component (chbC) from Escherichia coli (strain K12)

KEGG orthology group: K02761, PTS system, cellobiose-specific IIC component (inferred from 98% identity to enc:ECL_02438)

MetaCyc: 90% identical to N,N'-diacetylchitobiose-specific PTS enzyme IIC component (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-155B [EC: 2.7.1.196]

Predicted SEED Role

"PTS system, N,N'-diacetylchitobiose-specific IIC component"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.196

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>EX28DRAFT_1741 phosphotransferase system, cellobiose specific, IIC component (Enterobacter asburiae PDN3)
MSKVIASLEKVLLPFAVKIGKQPHVNAIKNGFIKLMPLTLAGAMFVLINNVFLSFGEGSF
FYSLGIRLDASTIETLNGFKAIGGNVYNGTLGIMSLMAPFFIGMALAEERKVDPLAAGLL
SVAAFMTVTPYSVGEAYAVGANWLGGANIISGIVIGLVVAEMFTFIIRRNWVIRLPDSVP
ASVSRSFSALIPGFIILSIMGIIAWALSHWGTNFHQIIMDSISTPLASMGGVVGWAYVIF
TSLLWFFGVHGSLALAALDSGIMTPWALENVALYQQYGSVDAALAAGKTFHVWAKPMLDS
YIFLGGTGATLGLIIAVFIVSRRADYRQVAKLALPSGIFQINEPILFGLPIIMNPVMFIP
FILIQPLLAAITLTAYYMGIIPPVTNIAPWTMPAGLGAFFNTNGSVAAFLLAIFNLGIAT
LLYMPFVAIANKAATIIDEEESEEDIALSLKF