Protein Info for BWI76_RS18925 in Klebsiella michiganensis M5al

Annotation: histidinol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 434 PF00815: Histidinol_dh" amino acids 29 to 427 (399 residues), 542.1 bits, see alignment E=4.9e-167 TIGR00069: histidinol dehydrogenase" amino acids 36 to 426 (391 residues), 528.2 bits, see alignment E=7.9e-163

Best Hits

Swiss-Prot: 88% identical to HISX_ECOL6: Histidinol dehydrogenase (hisD) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 94% identity to kpu:KP1_3680)

MetaCyc: 88% identical to histidinal/histidinol dehydrogenase (Escherichia coli K-12 substr. MG1655)
Histidinol dehydrogenase. [EC: 1.1.1.23]

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B685 at UniProt or InterPro

Protein Sequence (434 amino acids)

>BWI76_RS18925 histidinol dehydrogenase (Klebsiella michiganensis M5al)
MSFNTIIDWNGCSAEQQQQLLTRPAISASGSISKTVSEILTNVKDNGDAALREYSAKFDK
TDVKALKVSDEEIAAAGARLSDELKQAMAVAVKNIETFHNAQQLQAVDVETLPGVRCQQV
TRPIASVGLYIPGGSAPLFSTVLMLATPARIAGCQQVVLCSPPPIADEILYAAQLCGVRN
IFNVGGAQAIAALAFGTESVAKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL
VIADSGATPDFVASDLLSQAEHGPDSQVILLTPDSEMATRVAQAVERQLAALSRAETARG
ALSASRIIVARDIAQCVAISNQYGPEHLIIQTRNARELVDGITSAGSVFLGDWSPESAGD
YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSRDGFAALASTIEILAAAERLDAHK
NAVTLRVAALKEQA