Protein Info for MMJJ_RS01390 in Methanococcus maripaludis JJ

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 transmembrane" amino acids 20 to 37 (18 residues), see Phobius details amino acids 49 to 74 (26 residues), see Phobius details amino acids 99 to 121 (23 residues), see Phobius details amino acids 140 to 158 (19 residues), see Phobius details amino acids 166 to 189 (24 residues), see Phobius details amino acids 195 to 212 (18 residues), see Phobius details amino acids 240 to 262 (23 residues), see Phobius details amino acids 264 to 266 (3 residues), see Phobius details amino acids 272 to 297 (26 residues), see Phobius details amino acids 317 to 338 (22 residues), see Phobius details amino acids 358 to 380 (23 residues), see Phobius details amino acids 389 to 411 (23 residues), see Phobius details amino acids 417 to 437 (21 residues), see Phobius details PF01554: MatE" amino acids 23 to 184 (162 residues), 95.3 bits, see alignment E=1.6e-31 amino acids 250 to 400 (151 residues), 74.4 bits, see alignment E=4.4e-25 TIGR00797: MATE efflux family protein" amino acids 23 to 418 (396 residues), 185.4 bits, see alignment E=8.1e-59

Best Hits

KEGG orthology group: None (inferred from 99% identity to mmp:MMP0699)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (archaea)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (447 amino acids)

>MMJJ_RS01390 MATE family efflux transporter (Methanococcus maripaludis JJ)
MAYKSEFLGTEDVKKLLVKLSVPAIIGMLIMALYNIVDGFFIGRWVGTAAFTGIALIFPF
QMMIMAFGVTFGIGGSSLLSRKLGEGNLDLARKAGGNAISSVLILSVLITIVGVIFMVPI
LNLLGTSADIFPYAKDYYEIILYGTIFNSYLVAANNLVRAEGMAKIAMFAMVVPAIINII
LDPILIIVFNMGIKGAAIATVLSQIIGVIYIIKHQFGKNTSIKYAMNDFLINLKILKETV
FIGASEFAKLIISSILLILGNNLLGIYGGDIAIAIYGVIMRIAMLLLMPVLGIVQGFQPI
VGYNYGKGQLNRVSESIKLALVGTSGLCLLGFILVMIFPEKFIQIFITDPEVISQGVFAT
RIFFMFSFLIGAQMTIGGLYQSLGKAKPAFIISCARQTLFLMPALIILPLFFGLNGIWFS
FPIGDLLGFTLASGIIFKDRKSLNLSS