Protein Info for BWI76_RS24280 in Klebsiella michiganensis M5al

Annotation: biopolymer transporter ExbB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 243 transmembrane" amino acids 21 to 44 (24 residues), see Phobius details amino acids 132 to 154 (23 residues), see Phobius details amino acids 175 to 198 (24 residues), see Phobius details TIGR02797: tonB-system energizer ExbB" amino acids 11 to 222 (212 residues), 321.3 bits, see alignment E=1.6e-100 PF01618: MotA_ExbB" amino acids 90 to 204 (115 residues), 109.8 bits, see alignment E=4.1e-36

Best Hits

Swiss-Prot: 88% identical to EXBB_SALTI: Biopolymer transport protein ExbB (exbB) from Salmonella typhi

KEGG orthology group: K03561, biopolymer transport protein ExbB (inferred from 97% identity to kpu:KP1_4704)

MetaCyc: 84% identical to Ton complex subunit ExbB (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"MotA/TolQ/ExbB proton channel family protein" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A285B9W2 at UniProt or InterPro

Protein Sequence (243 amino acids)

>BWI76_RS24280 biopolymer transporter ExbB (Klebsiella michiganensis M5al)
MGNNLMQADLSVWGMYHHADIVVKVVMIGLILASVVTWAIFFGKGAEILASKRRLKREQQ
LVAEARSLDQASDIANAFEAKSLTSQLINEAQNELELSAGSEDNEGIKERTGFRLERRVA
AVGRYMGRGNGYLATIGAISPFVGLFGTVWGIMNSFIGIAQTQTTNLAVVAPGIAEALLA
TAIGLFAAIPAVVIYNIFARMIASYKASLGDVAAQVLLLQSRDLDLSASGVKPVRTAQKL
RVG