Negative cofitness for Pf6N2E2_4136 from Pseudomonas fluorescens FW300-N2E2

Aromatic ring-cleaving dioxygenase
SEED: Aromatic ring-cleaving dioxygenase
KEGG: DOPA 4,5-dioxygenase

Computing cofitness values with 388 experiments...

Genes with the strongest negative cofitness:

Rank	Hit	Name	Description	Cofit
1	Pf6N2E2_4754		Protein rarD	-0.38
2	Pf6N2E2_156		Carbon storage regulator	-0.36
3	Pf6N2E2_4795		Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY	-0.32
4	Pf6N2E2_5925		Transglutaminase-like enzymes, putative cysteine proteases	-0.32
5	Pf6N2E2_4432		Uroporphyrinogen-III synthase (EC 4.2.1.75)	-0.30
6	Pf6N2E2_4433		Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives)	-0.30
7	Pf6N2E2_3807		Histidine utilization repressor	-0.29
8	Pf6N2E2_3521		Sensor histidine kinase/response regulator	-0.29
9	Pf6N2E2_3192		tRNA:Cm32/Um32 methyltransferase	-0.29
10	Pf6N2E2_3151		Glutamate synthase [NADPH] small chain (EC 1.4.1.13)	-0.28
11	Pf6N2E2_4802		Thiosulfate sulfurtransferase GlpE (EC 2.8.1.1)	-0.28
12	Pf6N2E2_5132		NADH dehydrogenase (EC 1.6.99.3)	-0.28
13	Pf6N2E2_4262		GTP cyclohydrolase I (EC 3.5.4.16) type 2	-0.28
14	Pf6N2E2_5448		hypothetical protein	-0.28
15	Pf6N2E2_3918		D-cysteine desulfhydrase (EC 4.4.1.15)	-0.27
16	Pf6N2E2_5274		FolM Alternative dihydrofolate reductase 1	-0.27
17	Pf6N2E2_4803		Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC 3.6.1.41)	-0.27
18	Pf6N2E2_3917		High-affinity choline uptake protein BetT	-0.27
19	Pf6N2E2_5037		Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)	-0.27
20	Pf6N2E2_2278		Transcription-repair coupling factor	-0.26

Or look for positive cofitness