| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Pseudomonas syringae pv. syringae B728a | 1.0 | Psyr_0059 | | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal | 1.0 | Psyr_5088 | | regulatory protein, LuxR:Response regulator receiver | 0.41 | 19 |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 1.00 | Psyr_0059 | | HemY, N-terminal:HemY, N-terminal:HemY, N-terminal | 1.00 | Psyr_5088 | | regulatory protein, LuxR:Response regulator receiver | low | > 86 |
| Pseudomonas fluorescens FW300-N2C3 | 0.75 | AO356_12800 | | heme biosynthesis protein HemY | 0.68 | AO356_22615 | | nodulation protein NolW | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.75 | Pf6N2E2_4433 | | Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | 0.38 | Pf6N2E2_1724 | | DNA-binding response regulator, LuxR family | — | — |
| Pseudomonas sp. DMC3 | 0.73 | GFF355 | | Protein HemY | 0.53 | GFF1098 | | Response regulator protein TodT | — | — |
| Pseudomonas sp. RS175 | 0.71 | PFR28_04363 | | Protein HemY | 0.67 | PFR28_02521 | | Response regulator protein TmoT | — | — |
| Pseudomonas simiae WCS417 | 0.71 | PS417_27515 | | heme biosynthesis protein HemY | 0.41 | PS417_10320 | | hypothetical protein | low | > 88 |
| Pseudomonas fluorescens FW300-N1B4 | 0.69 | Pf1N1B4_2188 | | Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | 0.52 | Pf1N1B4_4408 | | two-component response regulator | — | — |
| Pseudomonas sp. SVBP6 | 0.68 | COO64_RS01180 | | heme biosynthesis protein HemY | 0.38 | COO64_RS17310 | | response regulator transcription factor | low | > 93 |
| Pseudomonas fluorescens GW456-L13 | 0.68 | PfGW456L13_859 | | Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | 0.36 | PfGW456L13_3749 | | Nitrogen regulation protein NR(I) | low | > 87 |
| Pseudomonas putida KT2440 | 0.63 | PP_0189 | | putative heme biosynthesis protein | 0.38 | PP_3551 | | DNA-binding response regulator, LuxR family | low | > 96 |
| Pseudomonas sp. BP01 | 0.63 | JOY50_RS18735 | | heme biosynthesis protein HemY | 0.38 | JOY50_RS28135 | | response regulator transcription factor | low | > 84 |
| Pseudomonas segetis P6 | 0.55 | MPMX49_04518 | | Protein HemY | 0.54 | MPMX49_00449 | | Response regulator protein TodT | low | > 75 |
| Pseudomonas sp. S08-1 | 0.46 | OH686_13915 | | Uncharacterized protein EC-HemY in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | 0.50 | OH686_18645 | | Two-component transcriptional response regulator, LuxR family | low | > 80 |
| Pseudomonas aeruginosa PA14 | 0.45 | IKLFDK_27170 | | heme biosynthesis protein HemY | 0.36 | IKLFDK_21605 | | two-component system response regulator BfiR | low | > 100 |
| Marinobacter adhaerens HP15 | 0.27 | HP15_237 | | HemY domain protein | 0.39 | HP15_1053 | | two component transcriptional regulator, LuxR family | low | > 73 |
| Serratia liquefaciens MT49 | 0.15 | IAI46_00680 | | protoheme IX biogenesis protein HemY | 0.29 | IAI46_04860 | | response regulator transcription factor | low | > 86 |
| Enterobacter sp. TBS_079 | 0.15 | MPMX20_04473 | | Protein HemY | 0.25 | MPMX20_01965 | | Response regulator protein TmoT | low | > 85 |
| Burkholderia phytofirmans PsJN | 0.15 | BPHYT_RS05240 | | heme biosynthesis protein HemY | 0.50 | BPHYT_RS11910 | | chemotaxis protein CheY | — | — |
| Pantoea sp. MT58 | 0.14 | IAI47_18440 | | protoheme IX biogenesis protein HemY | 0.40 | IAI47_20275 | | response regulator transcription factor | low | > 76 |
| Pantoea agglomerans CFBP13505 P0401 | 0.14 | PagCFBP13505_RS15420 | | protoheme IX biogenesis protein HemY | 0.39 | PagCFBP13505_RS13785 | | response regulator transcription factor | low | > 74 |
| Paraburkholderia bryophila 376MFSha3.1 | 0.14 | H281DRAFT_00200 | | HemY protein | 0.51 | H281DRAFT_03395 | | two component transcriptional regulator, LuxR family | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.14 | GFF226 | | Uncharacterized protein EC-HemY, likely associated with heme metabolism based on gene clustering with hemC, hemD in Proteobacteria (unrelated to HemY-type PPO in GramPositives) | 0.28 | GFF3576 | | Tetrathionate reductase two-component response regulator | low | > 78 |
| Enterobacter asburiae PDN3 | 0.14 | EX28DRAFT_4471 | | heme biosynthesis-associated TPR protein | 0.38 | EX28DRAFT_3507 | | Response regulator | low | > 76 |
| Paraburkholderia graminis OAS925 | 0.14 | ABIE53_001317 | | HemY protein | 0.54 | ABIE53_001505 | | FixJ family two-component response regulator | low | > 113 |
| Klebsiella michiganensis M5al | 0.14 | BWI76_RS01165 | | protoheme IX biogenesis protein HemY | 0.28 | BWI76_RS14640 | | DNA-binding response regulator | — | — |
| Dechlorosoma suillum PS | 0.13 | Dsui_1599 | | putative enzyme of heme biosynthesis | 0.40 | Dsui_2511 | | response regulator | low | > 51 |
| Paraburkholderia sabiae LMG 24235 | 0.13 | QEN71_RS24940 | | heme biosynthesis protein HemY | 0.53 | QEN71_RS39350 | | response regulator transcription factor | — | — |
| Ralstonia sp. UNC404CL21Col | 0.12 | ABZR87_RS16125 | | heme biosynthesis protein HemY | 0.36 | ABZR87_RS13480 | | response regulator transcription factor | — | — |
| Herbaspirillum seropedicae SmR1 | 0.12 | HSERO_RS14650 | | porphyrin biosynthesis protein | 0.42 | HSERO_RS22535 | | LuxR family transcriptional regulator | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.12 | RALBFv3_RS04235 | | heme biosynthesis protein HemY | 0.36 | RALBFv3_RS01680 | | DNA-binding response regulator | — | — |
| Ralstonia solanacearum UW163 | 0.12 | UW163_RS09435 | | heme biosynthesis protein HemY | 0.36 | UW163_RS14990 | | DNA-binding response regulator | — | — |
| Dickeya dadantii 3937 | 0.12 | DDA3937_RS19935 | | protoheme IX biogenesis protein HemY | 0.67 | DDA3937_RS07235 | | response regulator transcription factor | low | > 74 |
| Ralstonia solanacearum PSI07 | 0.12 | RPSI07_RS13115 | | heme biosynthesis protein HemY | 0.36 | RPSI07_RS15805 | | DNA-binding response regulator | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.12 | RR42_RS15890 | | heme biosynthesis protein HemY | 0.50 | RR42_RS25965 | | LuxR family transcriptional regulator | low | > 128 |
| Shewanella amazonensis SB2B | 0.10 | Sama_3257 | | HemY protein (RefSeq) | 0.32 | Sama_3183 | | response regulator receiver protein (RefSeq) | low | > 62 |
| Shewanella oneidensis MR-1 | 0.09 | SO4316 | | hemY protein, putative (NCBI ptt file) | 0.31 | SO4157 | | DNA-binding response regulator (NCBI ptt file) | low | > 76 |
| Shewanella sp. ANA-3 | 0.09 | Shewana3_0383 | | HemY domain-containing protein (RefSeq) | 0.31 | Shewana3_3697 | | two component LuxR family transcriptional regulator (RefSeq) | low | > 73 |
Not shown: 32 genomes with orthologs for Psyr_0059 only; 22 genomes with orthologs for Psyr_5088 only