| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Sphingobium sp. HT1-2 | 1.0 | GFF78 | | Putative oxidoreductase | 1.0 | GFF309 | | '16S rRNA (cytidine(1402)-2'-O)-methyltransferase (EC 2.1.1.198)' transl_table=11 | low | > 95 |
| Sphingomonas koreensis DSMZ 15582 | 0.54 | Ga0059261_3625 | | Short-chain dehydrogenases of various substrate specificities | 0.72 | Ga0059261_2755 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 68 |
| Rhizobium sp. OAE497 | 0.42 | ABIE40_RS06265 | | SDR family NAD(P)-dependent oxidoreductase | 0.40 | ABIE40_RS01370 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | 0.61 | 57 |
| Caulobacter crescentus NA1000 | 0.42 | CCNA_01728 | | short chain dehydrogenase | 0.42 | CCNA_00143 | | ribosomal RNA small subunit methyltransferase I | low | > 66 |
| Caulobacter crescentus NA1000 Δfur | 0.42 | CCNA_01728 | | short chain dehydrogenase | 0.42 | CCNA_00143 | | ribosomal RNA small subunit methyltransferase I | low | > 67 |
| Brevundimonas sp. GW460-12-10-14-LB2 | 0.41 | A4249_RS03730 | | SDR family NAD(P)-dependent oxidoreductase | 0.38 | A4249_RS13300 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | — | — |
| Agrobacterium fabrum C58 | 0.41 | Atu1074 | | NAD/NADP dependent oxidoreductase | 0.38 | Atu0302 | | tetrapyrrole methylase family protein | low | > 89 |
| Sinorhizobium meliloti 1021 | 0.40 | SMc00553 | | oxidoreductase | 0.45 | SMc00416 | | hypothetical protein | — | — |
| Azospirillum brasilense Sp245 | 0.40 | AZOBR_RS08305 | | oxidoreductase | 0.49 | AZOBR_RS02155 | | 16S rRNA methyltransferase | low | > 97 |
| Rhodopseudomonas palustris CGA009 | 0.39 | TX73_015995 | | SDR family NAD(P)-dependent oxidoreductase | 0.44 | TX73_001680 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | — | — |
| Azospirillum sp. SherDot2 | 0.39 | MPMX19_00907 | | putative oxidoreductase YciK | 0.49 | MPMX19_02471 | | Ribosomal RNA small subunit methyltransferase I | low | > 112 |
| Rhodospirillum rubrum S1H | 0.38 | Rru_A0403 | | Short-chain dehydrogenase/reductase SDR (NCBI) | 0.42 | Rru_A3693 | | Protein of unknown function UPF0011 (NCBI) | — | — |
| Xanthobacter sp. DMC5 | 0.37 | GFF1874 | | putative oxidoreductase YciK | 0.41 | GFF2243 | | Ribosomal RNA small subunit methyltransferase I | — | — |
| Magnetospirillum magneticum AMB-1 | 0.36 | AMB_RS10540 | | KR domain-containing protein | 0.43 | AMB_RS22780 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 64 |
| Bosea sp. OAE506 | 0.36 | ABIE41_RS17815 | | SDR family NAD(P)-dependent oxidoreductase | 0.42 | ABIE41_RS03315 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 77 |
| Dinoroseobacter shibae DFL-12 | 0.31 | Dshi_2135 | | short-chain dehydrogenase/reductase SDR (RefSeq) | 0.39 | Dshi_2831 | | Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase (RefSeq) | — | — |
| Alteromonas macleodii MIT1002 | 0.30 | MIT1002_01965 | | putative oxidoreductase YciK | 0.37 | MIT1002_03113 | | Ribosomal RNA small subunit methyltransferase I | low | > 70 |
| Kangiella aquimarina DSM 16071 | 0.30 | B158DRAFT_2314 | | Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) | 0.37 | B158DRAFT_2109 | | probable S-adenosylmethionine-dependent methyltransferase, YraL family | low | > 40 |
| Vibrio cholerae E7946 ATCC 55056 | 0.27 | CSW01_05390 | | YciK family oxidoreductase | 0.38 | CSW01_03090 | | rRNA (cytidine-2'-O-)-methyltransferase | low | > 62 |
| Shewanella loihica PV-4 | 0.27 | Shew_2409 | | short chain dehydrogenase (RefSeq) | 0.38 | Shew_0228 | | uroporphyrin-III C/tetrapyrrole methyltransferase (RefSeq) | low | > 60 |
| Pseudomonas fluorescens FW300-N2E3 | 0.27 | AO353_02105 | | 3-oxoacyl-ACP reductase | 0.34 | AO353_15290 | | methyltransferase | — | — |
| Pseudomonas fluorescens SBW25 | 0.27 | PFLU_RS08060 | | YciK family oxidoreductase | 0.32 | PFLU_RS04655 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 109 |
| Pseudomonas fluorescens SBW25-INTG | 0.27 | PFLU_RS08060 | | YciK family oxidoreductase | 0.32 | PFLU_RS04655 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 109 |
| Pseudomonas putida KT2440 | 0.26 | PP_1763 | | putative oxidoreductase | 0.34 | PP_1326 | | 16S rRNA 2'-O-ribose C1402 methyltransferase | low | > 96 |
| Pseudomonas simiae WCS417 | 0.26 | PS417_08090 | | 3-oxoacyl-ACP reductase | 0.33 | PS417_04590 | | methyltransferase | low | > 88 |
| Pseudomonas orientalis W4I3 | 0.26 | QF045_RS10810 | | YciK family oxidoreductase | 0.33 | QF045_RS07580 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 93 |
| Pseudomonas lactucae CFBP13502 | 0.26 | GEMAOFIL_01754 | | putative oxidoreductase YciK | 0.34 | GEMAOFIL_01121 | | Ribosomal RNA small subunit methyltransferase I | low | > 96 |
| Pseudomonas stutzeri RCH2 | 0.26 | Psest_2000 | | Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) | 0.32 | Psest_3270 | | probable S-adenosylmethionine-dependent methyltransferase, YraL family | low | > 67 |
| Pseudomonas fluorescens FW300-N2C3 | 0.26 | AO356_03500 | | 3-oxoacyl-ACP reductase | 0.35 | AO356_17110 | | methyltransferase | low | > 104 |
| Enterobacter asburiae PDN3 | 0.26 | EX28DRAFT_0942 | | Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) | 0.33 | EX28DRAFT_3195 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 76 |
| Shewanella oneidensis MR-1 | 0.26 | SO2935 | | oxidoreductase, short-chain dehydrogenase/reductase family (NCBI ptt file) | 0.38 | SO0301 | | hypothetical methyltransferase (NCBI ptt file) | low | > 76 |
| Pseudomonas fluorescens GW456-L13 | 0.26 | PfGW456L13_2169 | | Oxidoreductase, short chain dehydrogenase/reductase family | 0.33 | PfGW456L13_1643 | | rRNA small subunit methyltransferase I | low | > 87 |
| Shewanella amazonensis SB2B | 0.26 | Sama_2121 | | short chain dehydrogenase (RefSeq) | 0.37 | Sama_3353 | | hypothetical protein (RefSeq) | low | > 62 |
| Pseudomonas sp. S08-1 | 0.26 | OH686_20835 | | Oxidoreductase, short-chain dehydrogenase/reductase family | 0.31 | OH686_08340 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | 0.68 | 73 |
| Acinetobacter baumannii LAC-4 | 0.26 | RR41_RS18735 | | YciK family oxidoreductase | 0.36 | RR41_RS09275 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 55 |
| Pseudomonas segetis P6 | 0.26 | MPMX49_02906 | | putative oxidoreductase YciK | 0.36 | MPMX49_03819 | | Ribosomal RNA small subunit methyltransferase I | low | > 75 |
| Pseudomonas fluorescens FW300-N1B4 | 0.26 | Pf1N1B4_358 | | Oxidoreductase, short chain dehydrogenase/reductase family | 0.33 | Pf1N1B4_953 | | rRNA small subunit methyltransferase I | — | — |
| Pseudomonas sp. DMC3 | 0.26 | GFF4684 | | putative oxidoreductase YciK | 0.34 | GFF4428 | | Ribosomal RNA small subunit methyltransferase I | low | > 89 |
| Marinobacter adhaerens HP15 | 0.25 | HP15_1225 | | oxidoreductase, short chain dehydrogenase/reductase family | 0.40 | HP15_554 | | tetrapyrrole methylase family protein | low | > 73 |
| Pseudomonas sp. RS175 | 0.25 | PFR28_00899 | | putative oxidoreductase YciK | 0.33 | PFR28_03597 | | Ribosomal RNA small subunit methyltransferase I | — | — |
| Pseudomonas sp. BP01 | 0.25 | JOY50_RS16170 | | YciK family oxidoreductase | 0.33 | JOY50_RS15165 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 84 |
| Pseudomonas aeruginosa PUPa3 | 0.25 | DQ20_RS34470 | | YciK family oxidoreductase | 0.33 | DQ20_RS56825 | rsmI;go_function=rRNA | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 101 |
| Pseudomonas fluorescens FW300-N2E2 | 0.25 | Pf6N2E2_2527 | | Oxidoreductase, short chain dehydrogenase/reductase family | 0.33 | Pf6N2E2_5346 | | rRNA small subunit methyltransferase I | low | > 103 |
| Pseudomonas aeruginosa MRSN321 | 0.25 | DY961_RS01075 | | YciK family oxidoreductase | 0.34 | DY961_RS24365 | rsmI;go_function=rRNA | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 100 |
| Pseudomonas aeruginosa PA14 | 0.25 | IKLFDK_16125 | | YciK family oxidoreductase | 0.34 | IKLFDK_01980 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | — | — |
| Acinetobacter radioresistens SK82 | 0.25 | MPMX26_00032 | | putative oxidoreductase YciK | 0.36 | MPMX26_02282 | | Ribosomal RNA small subunit methyltransferase I | low | > 36 |
| Shewanella sp. ANA-3 | 0.25 | Shewana3_1528 | | short chain dehydrogenase (RefSeq) | 0.39 | Shewana3_3879 | | hypothetical protein (RefSeq) | low | > 73 |
| Dickeya dianthicola 67-19 | 0.25 | HGI48_RS10510 | | YciK family oxidoreductase | 0.35 | HGI48_RS01610 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 71 |
| Pseudomonas sp. SVBP6 | 0.25 | COO64_RS06780 | | YciK family oxidoreductase | 0.34 | COO64_RS11845 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 93 |
| Escherichia fergusonii Becca | 0.25 | EFB2_02656 | | putative oxidoreductase YciK | 0.36 | EFB2_00677 | | Ribosomal RNA small subunit methyltransferase I | low | > 86 |
| Escherichia coli Nissle 1917 | 0.25 | ECOLIN_RS07645 | | YciK family oxidoreductase | 0.36 | ECOLIN_RS18085 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.25 | Psyr_3652 | | Short-chain dehydrogenase/reductase SDR | 0.35 | Psyr_4112 | | Protein of unknown function UPF0011 | low | > 86 |
| Pseudomonas syringae pv. syringae B728a | 0.25 | Psyr_3652 | | Short-chain dehydrogenase/reductase SDR | 0.35 | Psyr_4112 | | Protein of unknown function UPF0011 | low | > 86 |
| Dickeya dadantii 3937 | 0.24 | DDA3937_RS10510 | | YciK family oxidoreductase | 0.35 | DDA3937_RS01715 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 74 |
| Klebsiella michiganensis M5al | 0.24 | BWI76_RS11905 | | NAD(P)-dependent oxidoreductase | 0.32 | BWI76_RS24910 | | rRNA (cytidine-2'-O-)-methyltransferase | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.24 | PagCFBP13505_RS06965 | | YciK family oxidoreductase | 0.33 | PagCFBP13505_RS11450 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 74 |
| Escherichia coli BL21 | 0.24 | ECD_01247 | | putative EmrKY-TolC system oxoacyl-(acyl carrier protein) reductase | 0.36 | ECD_03013 | | 16S rRNA C1402 2'-O-ribose methyltransferase, SAM-dependent | low | > 61 |
| Escherichia coli ECOR27 | 0.24 | NOLOHH_20285 | yciK | YciK family oxidoreductase | 0.35 | NOLOHH_10035 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 76 |
| Dickeya dianthicola ME23 | 0.24 | DZA65_RS10990 | | YciK family oxidoreductase | 0.35 | DZA65_RS01685 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 75 |
| Pectobacterium carotovorum WPP14 | 0.24 | HER17_RS10890 | | YciK family oxidoreductase | 0.34 | HER17_RS19860 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 75 |
| Escherichia coli BW25113 | 0.24 | b1271 | yciK | short chain dehydrogenase (NCBI) | 0.36 | b3146 | yraL | predicted methyltransferase (NCBI) | low | > 76 |
| Enterobacter sp. TBS_079 | 0.24 | MPMX20_02505 | | putative oxidoreductase YciK | 0.32 | MPMX20_04050 | | Ribosomal RNA small subunit methyltransferase I | low | > 85 |
| Escherichia coli ECRC101 | 0.24 | MCAODC_15645 | yciK | YciK family oxidoreductase | 0.36 | MCAODC_08755 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 87 |
| Escherichia coli ECRC98 | 0.24 | JDDGAC_05165 | yciK | YciK family oxidoreductase | 0.36 | JDDGAC_21860 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 87 |
| Escherichia coli ECOR38 | 0.24 | HEPCGN_25580 | yciK | YciK family oxidoreductase | 0.36 | HEPCGN_17110 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 88 |
| Escherichia coli ECRC100 | 0.24 | OKFHMN_02620 | yciK | YciK family oxidoreductase | 0.36 | OKFHMN_18235 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 79 |
| Escherichia coli ECRC62 | 0.24 | BNILDI_18435 | yciK | YciK family oxidoreductase | 0.35 | BNILDI_01495 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 75 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.24 | OHPLBJKB_02413 | | putative oxidoreductase YciK | 0.36 | OHPLBJKB_00555 | | Ribosomal RNA small subunit methyltransferase I | low | > 74 |
| Escherichia coli ECRC99 | 0.24 | KEDOAH_26145 | yciK | YciK family oxidoreductase | 0.36 | KEDOAH_09915 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | — | — |
| Escherichia coli ECRC102 | 0.24 | NIAGMN_26790 | yciK | YciK family oxidoreductase | 0.36 | NIAGMN_15995 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 80 |
| Pantoea sp. MT58 | 0.24 | IAI47_09220 | | YciK family oxidoreductase | 0.32 | IAI47_02850 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 76 |
| Serratia liquefaciens MT49 | 0.23 | IAI46_13985 | | YciK family oxidoreductase | 0.30 | IAI46_22295 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 87 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.23 | GFF2717 | | YciK-like oxidoreductase | 0.33 | GFF1521 | | rRNA small subunit methyltransferase I | low | > 78 |
| Phaeobacter inhibens DSM 17395 | 0.23 | PGA1_c10780 | | putative short chain dehydrogenase | 0.31 | PGA1_c26730 | | probable S-adenosylmethionine-dependent methyltransferase, YraL family | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.23 | IJEDHG_23560 | | YciK family oxidoreductase | 0.34 | IJEDHG_06680 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 61 |
| Erwinia tracheiphila SCR3 | 0.23 | LU632_RS12725 | | YciK family oxidoreductase | 0.34 | LU632_RS02230 | rsmI | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 73 |
| Erwinia amylovora T8 | 0.22 | OLJFJH_13515 | | YciK family oxidoreductase | 0.35 | OLJFJH_02280 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 58 |
| Rahnella sp. WP5 | 0.22 | EX31_RS09910 | | YciK family oxidoreductase | 0.35 | EX31_RS12550 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 89 |
| Lysobacter sp. OAE881 | 0.19 | ABIE51_RS15375 | | SDR family NAD(P)-dependent oxidoreductase | 0.38 | ABIE51_RS04695 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 62 |
| Dyella japonica UNC79MFTsu3.2 | 0.19 | ABZR86_RS09815 | | SDR family NAD(P)-dependent oxidoreductase | 0.36 | ABZR86_RS11380 | | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | low | > 74 |
Not shown: 0 genomes with orthologs for GFF78 only; 30 genomes with orthologs for GFF309 only