| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Sphingobium sp. HT1-2 | 1.0 | GFF4764 | | Threonine synthase (EC 4.2.3.1) | 1.0 | GFF2630 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | 0.86 | 5 |
| Sphingomonas koreensis DSMZ 15582 | 0.79 | Ga0059261_1999 | | threonine synthase | 0.77 | Ga0059261_4223 | | 3-isopropylmalate dehydratase, large subunit | 0.98 | 5 |
| Azospirillum sp. SherDot2 | 0.58 | MPMX19_00671 | | Threonine synthase | 0.66 | MPMX19_01998 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Azospirillum brasilense Sp245 | 0.57 | AZOBR_RS10545 | | threonine synthase | 0.66 | AZOBR_RS03545 | | isopropylmalate isomerase | — | — |
| Magnetospirillum magneticum AMB-1 | 0.57 | AMB_RS17140 | | threonine synthase | 0.65 | AMB_RS20560 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Pseudomonas aeruginosa PA14 | 0.55 | IKLFDK_19070 | | threonine synthase | 0.59 | IKLFDK_15880 | | 3-isopropylmalate dehydratase large subunit | low | > 100 |
| Dinoroseobacter shibae DFL-12 | 0.55 | Dshi_1146 | | threonine synthase (RefSeq) | 0.60 | Dshi_0085 | | 3-isopropylmalate dehydratase, large subunit (RefSeq) | — | — |
| Rhodospirillum rubrum S1H | 0.54 | Rru_A3233 | | Threonine synthase (NCBI) | 0.64 | Rru_A1189 | | 3-isopropylmalate dehydratase large subunit region (NCBI) | — | — |
| Pseudomonas stutzeri RCH2 | 0.54 | Psest_3125 | | threonine synthase | 0.60 | Psest_2591 | | 3-isopropylmalate dehydratase, large subunit | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.54 | AO353_04350 | | threonine synthase | 0.61 | AO353_20620 | | isopropylmalate isomerase | — | — |
| Pseudomonas sp. RS175 | 0.54 | PFR28_00334 | | Threonine synthase | 0.60 | PFR28_02824 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.54 | Pf1N1B4_3014 | | Threonine synthase (EC 4.2.3.1) | 0.61 | Pf1N1B4_15 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | — | — |
| Pseudomonas sp. S08-1 | 0.54 | OH686_17765 | | threonine synthase | 0.60 | OH686_04480 | | 3-isopropylmalate dehydratase large subunit | low | > 80 |
| Marinobacter adhaerens HP15 | 0.53 | HP15_765 | | threonine synthase | 0.58 | HP15_1834 | | protein containing 3-isopropylmalate dehydratase, large subunit region domain | — | — |
| Pseudomonas segetis P6 | 0.53 | MPMX49_01578 | | Threonine synthase | 0.59 | MPMX49_03074 | | 3-isopropylmalate dehydratase large subunit | 0.88 | 6 |
| Pseudomonas sp. BP01 | 0.53 | JOY50_RS11715 | thrC | threonine synthase | 0.60 | JOY50_RS16630 | leuC | 3-isopropylmalate dehydratase large subunit | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.53 | PfGW456L13_1724 | | Threonine synthase (EC 4.2.3.1) | 0.61 | PfGW456L13_3948 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | — | — |
| Pseudomonas putida KT2440 | 0.53 | PP_1471 | | Threonine synthase | 0.60 | PP_1985 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.53 | Pf6N2E2_3142 | | Threonine synthase (EC 4.2.3.1) | 0.60 | Pf6N2E2_63 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | — | — |
| Pseudomonas sp. DMC3 | 0.53 | GFF1990 | | Threonine synthase | 0.60 | GFF785 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.53 | AO356_06370 | | threonine synthase | 0.61 | AO356_21400 | | isopropylmalate isomerase | — | — |
| Pseudomonas simiae WCS417 | 0.53 | PS417_22880 | | threonine synthase | 0.61 | PS417_18600 | | isopropylmalate isomerase | — | — |
| Pseudomonas lactucae CFBP13502 | 0.53 | GEMAOFIL_04726 | | Threonine synthase | 0.61 | GEMAOFIL_03948 | | 3-isopropylmalate dehydratase large subunit | low | > 93 |
| Pseudomonas sp. SVBP6 | 0.53 | COO64_RS04940 | thrC | threonine synthase | 0.61 | COO64_RS05665 | leuC | 3-isopropylmalate dehydratase large subunit | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.52 | Psyr_1291 | | L-threonine synthase | 0.60 | Psyr_1983 | | 3-isopropylmalate dehydratase, large subunit | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.52 | Psyr_1291 | | L-threonine synthase | 0.60 | Psyr_1983 | | 3-isopropylmalate dehydratase, large subunit | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.52 | PFLU_RS24545 | | threonine synthase | 0.61 | PFLU_RS20580 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Pseudomonas fluorescens SBW25 | 0.52 | PFLU_RS24545 | | threonine synthase | 0.61 | PFLU_RS20580 | | 3-isopropylmalate dehydratase large subunit | low | > 109 |
| Phaeobacter inhibens DSM 17395 | 0.52 | PGA1_c06310 | | threonine synthase ThrC | 0.61 | PGA1_c29780 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Rhizobium sp. OAE497 | 0.50 | ABIE40_RS04230 | | threonine synthase | 0.60 | ABIE40_RS18380 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Sinorhizobium meliloti 1021 | 0.50 | SMc00077 | | threonine synthase | 0.63 | SMc03823 | | isopropylmalate isomerase large subunit | — | — |
| Bosea sp. OAE506 | 0.50 | ABIE41_RS22985 | | threonine synthase | 0.65 | ABIE41_RS11660 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Xanthobacter sp. DMC5 | 0.49 | GFF1319 | | Threonine synthase | 0.59 | GFF1852 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Rhodopseudomonas palustris CGA009 | 0.49 | TX73_004325 | | threonine synthase | 0.62 | TX73_001245 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Agrobacterium fabrum C58 | 0.49 | Atu0787 | | threonine synthase | 0.62 | Atu2709 | | 3-isopropylmalate dehydratase, large subunit | — | — |
| Caulobacter crescentus NA1000 | 0.48 | CCNA_03510 | | threonine synthase | 0.60 | CCNA_00196 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Caulobacter crescentus NA1000 Δfur | 0.48 | CCNA_03510 | | threonine synthase | 0.60 | CCNA_00196 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Acidovorax sp. GW101-3H11 | 0.36 | Ac3H11_1505 | | Threonine synthase (EC 4.2.3.1) | 0.58 | Ac3H11_1525 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | — | — |
| Variovorax sp. SCN45 | 0.36 | GFF2800 | | Threonine synthase (EC 4.2.3.1) | 0.58 | GFF3890 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | — | — |
| Ralstonia sp. UNC404CL21Col | 0.35 | ABZR87_RS11450 | | threonine synthase | 0.58 | ABZR87_RS14540 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Brevundimonas sp. GW460-12-10-14-LB2 | 0.35 | A4249_RS00020 | | threonine synthase | 0.48 | A4249_RS10005 | | 3-isopropylmalate dehydratase large subunit | 0.99 | 9 |
| Methylophilus sp. DMC18 | 0.35 | GFF1164 | | Threonine synthase | 0.61 | GFF646 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Dechlorosoma suillum PS | 0.35 | Dsui_2904 | | threonine synthase | 0.57 | Dsui_3201 | | 3-isopropylmalate dehydratase, large subunit | — | — |
| Variovorax sp. OAS795 | 0.35 | ABID97_RS10895 | | threonine synthase | 0.59 | ABID97_RS08465 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Ralstonia solanacearum GMI1000 | 0.35 | RS_RS06660 | | threonine synthase | 0.58 | RS_RS10000 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Ralstonia solanacearum UW163 | 0.35 | UW163_RS13325 | | threonine synthase | 0.58 | UW163_RS11105 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.35 | RALBFv3_RS15880 | | threonine synthase | 0.58 | RALBFv3_RS02620 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Ralstonia solanacearum PSI07 | 0.34 | RPSI07_RS17485 | | threonine synthase | 0.58 | RPSI07_RS14695 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.34 | RR42_RS12535 | | threonine synthase | 0.58 | RR42_RS14400 | | isopropylmalate isomerase | — | — |
| Paraburkholderia sabiae LMG 24235 | 0.34 | QEN71_RS22400 | | threonine synthase | 0.57 | QEN71_RS17605 | | 3-isopropylmalate dehydratase large subunit | 0.74 | 48 |
| Paraburkholderia graminis OAS925 | 0.34 | ABIE53_002027 | | threonine synthase | 0.58 | ABIE53_004801 | | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit | — | — |
| Burkholderia phytofirmans PsJN | 0.34 | BPHYT_RS08960 | | threonine synthase | 0.57 | BPHYT_RS33915 | | isopropylmalate isomerase | 0.63 | 58 |
| Herbaspirillum seropedicae SmR1 | 0.34 | HSERO_RS10470 | | threonine synthase | 0.58 | HSERO_RS16515 | | isopropylmalate isomerase | — | — |
| Paraburkholderia bryophila 376MFSha3.1 | 0.34 | H281DRAFT_00811 | | L-threonine synthase | 0.58 | H281DRAFT_06075 | | 3-isopropylmalate dehydratase, large subunit | — | — |
| Castellaniella sp019104865 MT123 | 0.33 | ABCV34_RS02300 | | threonine synthase | 0.60 | ABCV34_RS04290 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.33 | GFF3936 | | Threonine synthase (EC 4.2.3.1) | 0.58 | GFF3363 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | — | — |
| Phocaeicola dorei CL03T12C01 | 0.27 | ABI39_RS10440 | | threonine synthase | 0.51 | ABI39_RS10200 | | 3-isopropylmalate dehydratase large subunit | 0.88 | 4 |
| Phocaeicola vulgatus CL09T03C04 | 0.27 | HMPREF1058_RS14730 | | threonine synthase | 0.50 | HMPREF1058_RS14550 | | 3-isopropylmalate dehydratase large subunit | 0.81 | 30 |
| Bifidobacterium breve UCC2003 | 0.26 | BBR_RS14070 | | threonine synthase (EC 4.2.3.1) (from data) | 0.53 | BBR_RS19630 | | 3-isopropylmalate dehydratase large subunit | low | > 34 |
| Parabacteroides merdae CL09T00C40 | 0.26 | HMPREF1078_RS10395 | | threonine synthase | 0.50 | HMPREF1078_RS16660 | | 3-isopropylmalate dehydratase large subunit | 0.92 | 23 |
| Bacteroides stercoris CC31F | 0.26 | HMPREF1181_RS00050 | | threonine synthase | 0.50 | HMPREF1181_RS14145 | | 3-isopropylmalate dehydratase large subunit | 0.92 | 28 |
| Bacteroides thetaiotaomicron VPI-5482 | 0.26 | BT2401 | | threonine synthase (NCBI ptt file) | 0.50 | BT1860 | | 3-isopropylmalate dehydratase large subunit (NCBI ptt file) | 0.90 | 29 |
| Bacteroides ovatus ATCC 8483 | 0.26 | BACOVA_03023 | | threonine synthase | 0.50 | BACOVA_04603 | | 3-isopropylmalate dehydratase, large subunit | 0.94 | 20 |
| Echinicola vietnamensis KMM 6221, DSM 17526 | 0.25 | Echvi_2002 | | threonine synthase | 0.48 | Echvi_2059 | | 3-isopropylmalate dehydratase, large subunit | 0.73 | 48 |
| Alteromonas macleodii MIT1002 | 0.25 | MIT1002_03084 | | Threonine synthase | 0.57 | MIT1002_00947 | | 3-isopropylmalate dehydratase large subunit | 0.92 | 34 |
| Shewanella sp. ANA-3 | 0.25 | Shewana3_1141 | | threonine synthase (RefSeq) | 0.57 | Shewana3_3759 | | isopropylmalate isomerase large subunit (RefSeq) | 0.93 | 19 |
| Cellulophaga baltica 18 | 0.25 | M666_RS11605 | | threonine synthase | 0.51 | M666_RS15060 | | 3-isopropylmalate dehydratase large subunit | low | > 67 |
| Shewanella oneidensis MR-1 | 0.24 | SO3413 | thrC | threonine synthase (NCBI ptt file) | 0.56 | SO4234 | leuC | 3-isopropylmalate dehydratase, large subunit (NCBI ptt file) | 0.97 | 11 |
| Pantoea agglomerans CFBP13505 P0401 | 0.24 | PagCFBP13505_RS21900 | | threonine synthase | 0.57 | PagCFBP13505_RS12990 | | 3-isopropylmalate dehydratase large subunit | low | > 74 |
| Enterobacter asburiae PDN3 | 0.24 | EX28DRAFT_3616 | | threonine synthase | 0.57 | EX28DRAFT_3668 | | 3-isopropylmalate dehydratase, large subunit | 0.51 | 32 |
| Enterobacter sp. TBS_079 | 0.24 | MPMX20_00712 | | Threonine synthase | 0.57 | MPMX20_00767 | | 3-isopropylmalate dehydratase large subunit 1 | 0.91 | 20 |
| Dickeya dadantii 3937 | 0.24 | DDA3937_RS18405 | | threonine synthase | 0.59 | DDA3937_RS18125 | | 3-isopropylmalate dehydratase large subunit | 0.67 | 72 |
| Dickeya dianthicola 67-19 | 0.24 | HGI48_RS18335 | | threonine synthase | 0.58 | HGI48_RS18065 | | 3-isopropylmalate dehydratase large subunit | 0.81 | 1 |
| Dickeya dianthicola ME23 | 0.24 | DZA65_RS19475 | | threonine synthase | 0.58 | DZA65_RS19210 | | 3-isopropylmalate dehydratase large subunit | 0.71 | 8 |
| Erwinia amylovora T8 | 0.24 | OLJFJH_01485 | | threonine synthase | 0.55 | OLJFJH_01295 | | 3-isopropylmalate dehydratase large subunit | 0.93 | 7 |
| Klebsiella pneumoniae MKP103 | 0.24 | KDGMDA_12520 | | threonine synthase | 0.58 | KDGMDA_12900 | | 3-isopropylmalate dehydratase large subunit 1 | low | > 95 |
| Lysobacter sp. OAE881 | 0.24 | ABIE51_RS17530 | | threonine synthase | 0.48 | ABIE51_RS17575 | | 3-isopropylmalate dehydratase large subunit | 0.92 | 47 |
| Serratia liquefaciens MT49 | 0.24 | IAI46_03040 | | threonine synthase | 0.56 | IAI46_03345 | | 3-isopropylmalate dehydratase large subunit | 0.76 | 34 |
| Pantoea sp. MT58 | 0.24 | IAI47_16205 | | threonine synthase | 0.57 | IAI47_16010 | | 3-isopropylmalate dehydratase large subunit | 0.94 | 8 |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.24 | ABZR88_RS18960 | | threonine synthase | 0.51 | ABZR88_RS11595 | | 3-isopropylmalate dehydratase large subunit | — | — |
| Shewanella loihica PV-4 | 0.24 | Shew_1081 | | threonine synthase (RefSeq) | 0.56 | Shew_3470 | | isopropylmalate isomerase large subunit (RefSeq) | 0.98 | 11 |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.23 | CA265_RS23465 | | threonine synthase | 0.51 | CA265_RS15830 | | 3-isopropylmalate dehydratase large subunit | 0.88 | 5 |
| Rahnella sp. WP5 | 0.23 | EX31_RS03935 | | threonine synthase | 0.58 | EX31_RS03690 | | 3-isopropylmalate dehydratase large subunit | 0.99 | 3 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.23 | GFF1080 | | Threonine synthase (EC 4.2.3.1) | 0.57 | GFF166 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | low | > 78 |
| Erwinia tracheiphila HP pepo 2.2 | 0.23 | IJEDHG_06290 | thrC | threonine synthase | 0.53 | IJEDHG_06005 | leuC | 3-isopropylmalate dehydratase large subunit | — | — |
| Erwinia tracheiphila SCR3 | 0.23 | LU632_RS02620 | thrC | threonine synthase | 0.53 | LU632_RS02870 | leuC | 3-isopropylmalate dehydratase large subunit | — | — |
| Klebsiella michiganensis M5al | 0.23 | BWI76_RS04255 | | threonine synthase | 0.57 | BWI76_RS04670 | | 3-isopropylmalate dehydratase large subunit | 0.93 | 12 |
| Escherichia coli ECRC99 | 0.23 | KEDOAH_17055 | thrC | threonine synthase | 0.57 | KEDOAH_17430 | leuC1 | 3-isopropylmalate dehydratase large subunit 1 | — | — |
| Escherichia coli BL21 | 0.23 | ECD_00004 | | L-threonine synthase | 0.57 | ECD_00074 | | 3-isopropylmalate dehydratase large subunit | 0.95 | 10 |
| Escherichia coli ECRC62 | 0.23 | BNILDI_08170 | thrC | threonine synthase | 0.57 | BNILDI_08540 | leuC1 | 3-isopropylmalate dehydratase large subunit 1 | 0.92 | 13 |
| Escherichia coli Nissle 1917 | 0.23 | ECOLIN_RS00020 | | threonine synthase | 0.57 | ECOLIN_RS00390 | | 3-isopropylmalate dehydratase large subunit | low | > 55 |
| Escherichia fergusonii Becca | 0.23 | EFB2_04039 | | Threonine synthase | 0.58 | EFB2_03973 | | 3-isopropylmalate dehydratase large subunit | low | > 86 |
| Escherichia coli BW25113 | 0.23 | b0004 | thrC | threonine synthase (NCBI) | 0.57 | b0072 | leuC | isopropylmalate isomerase large subunit (NCBI) | 0.89 | 32 |
| Escherichia coli ECRC101 | 0.23 | MCAODC_01615 | thrC | threonine synthase | 0.57 | MCAODC_01240 | leuC1 | 3-isopropylmalate dehydratase large subunit 1 | 0.78 | 36 |
| Escherichia coli ECRC102 | 0.23 | NIAGMN_08950 | thrC | threonine synthase | 0.57 | NIAGMN_08575 | leuC1 | 3-isopropylmalate dehydratase large subunit 1 | 0.96 | 39 |
| Escherichia coli ECRC100 | 0.23 | OKFHMN_11100 | thrC | threonine synthase | 0.57 | OKFHMN_10725 | leuC1 | 3-isopropylmalate dehydratase large subunit 1 | 0.98 | 29 |
| Escherichia coli ECRC98 | 0.23 | JDDGAC_14695 | thrC | threonine synthase | 0.57 | JDDGAC_14320 | leuC1 | 3-isopropylmalate dehydratase large subunit 1 | 0.85 | 21 |
| Escherichia coli ECOR27 | 0.23 | NOLOHH_03430 | thrC | threonine synthase | 0.57 | NOLOHH_03070 | leuC1 | 3-isopropylmalate dehydratase large subunit 1 | 0.98 | 1 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.23 | OHPLBJKB_03656 | | Threonine synthase | 0.57 | OHPLBJKB_03585 | | 3-isopropylmalate dehydratase large subunit | low | > 74 |
| Shewanella amazonensis SB2B | 0.23 | Sama_0907 | | threonine synthase (RefSeq) | 0.55 | Sama_0337 | | isopropylmalate isomerase large subunit (RefSeq) | 0.94 | 15 |
| Escherichia coli ECOR38 | 0.23 | HEPCGN_09105 | thrC | threonine synthase | 0.57 | HEPCGN_08705 | leuC1 | 3-isopropylmalate dehydratase large subunit 1 | 0.90 | 21 |
| Vibrio cholerae E7946 ATCC 55056 | 0.23 | CSW01_11965 | | threonine synthase | 0.54 | CSW01_12605 | | 3-isopropylmalate dehydratase large subunit | low | > 62 |
| Pectobacterium carotovorum WPP14 | 0.23 | HER17_RS02805 | | threonine synthase | 0.58 | HER17_RS03075 | | 3-isopropylmalate dehydratase large subunit | 0.95 | 5 |
| Xanthomonas campestris pv. campestris strain 8004 | 0.22 | Xcc-8004.2954.1 | | Threonine synthase (EC 4.2.3.1) | 0.61 | Xcc-8004.1049.1 | | 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) | 0.79 | 29 |
| Rhodanobacter sp. FW510-T8 | 0.22 | OKGIIK_13570 | thrC | threonine synthase | 0.47 | OKGIIK_13585 | leuC | 3-isopropylmalate dehydratase large subunit | low | > 53 |
| Dyella japonica UNC79MFTsu3.2 | 0.22 | ABZR86_RS15975 | | threonine synthase (EC 4.2.3.1) (from data) | 0.48 | ABZR86_RS15960 | | 3-isopropylmalate dehydratase large subunit | 0.96 | 21 |
| Rhodanobacter sp000427505 FW510-R12 | 0.22 | LRK53_RS03155 | | threonine synthase | 0.50 | LRK53_RS16375 | | 3-isopropylmalate dehydratase large subunit | low | > 59 |
| Rhodanobacter denitrificans FW104-10B01 | 0.21 | LRK54_RS10355 | | threonine synthase | 0.55 | LRK54_RS07375 | | 3-isopropylmalate dehydratase large subunit | low | > 59 |
| Rhodanobacter denitrificans MT42 | 0.20 | LRK55_RS09995 | | threonine synthase | 0.55 | LRK55_RS07105 | | 3-isopropylmalate dehydratase large subunit | low | > 63 |
Not shown: 0 genomes with orthologs for GFF4764 only; 11 genomes with orthologs for GFF2630 only