| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_09720 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 1.0 | CSW01_11560 | | riboflavin biosynthesis protein RibD | 0.80 | 13 |
| Rahnella sp. WP5 | 0.69 | EX31_RS22835 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | EX31_RS22125 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Klebsiella michiganensis M5al | 0.68 | BWI76_RS07100 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.52 | BWI76_RS06350 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase | — | — |
| Serratia liquefaciens MT49 | 0.68 | IAI46_05400 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | IAI46_04895 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Klebsiella pneumoniae MKP103 | 0.68 | KDGMDA_15035 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | KDGMDA_14440 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Enterobacter asburiae PDN3 | 0.68 | EX28DRAFT_2449 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.53 | EX28DRAFT_2556 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) | — | — |
| Pantoea sp. MT58 | 0.68 | IAI47_14320 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | IAI47_14770 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Shewanella amazonensis SB2B | 0.68 | Sama_1222 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.48 | Sama_1016 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase., 5-amino-6-(5-phosphoribosylamino)uracil reductase (RefSeq) | — | — |
| Enterobacter sp. TBS_079 | 0.68 | MPMX20_01107 | | Bifunctional protein FolD protein | 0.51 | MPMX20_01006 | | Riboflavin biosynthesis protein RibD | — | — |
| Escherichia coli BW25113 | 0.68 | b0529 | folD | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase (NCBI) | 0.53 | b0414 | ribD | fused diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (NCBI) | — | — |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.68 | OHPLBJKB_03152 | | Bifunctional protein FolD protein | 0.53 | OHPLBJKB_03262 | | Riboflavin biosynthesis protein RibD | — | — |
| Escherichia coli ECRC102 | 0.68 | NIAGMN_05860 | | Bifunctional protein FolD | 0.51 | NIAGMN_06510 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Escherichia coli ECRC98 | 0.68 | JDDGAC_11455 | | Bifunctional protein FolD | 0.51 | JDDGAC_12110 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Shewanella sp. ANA-3 | 0.68 | Shewana3_2663 | | methenyltetrahydrofolate cyclohydrolase (RefSeq) | 0.50 | Shewana3_1096 | | 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase (RefSeq) | — | — |
| Escherichia fergusonii Becca | 0.68 | EFB2_03532 | | Bifunctional protein FolD protein | 0.51 | EFB2_03643 | | Riboflavin biosynthesis protein RibD | — | — |
| Escherichia coli ECRC101 | 0.68 | MCAODC_27025 | | Bifunctional protein FolD | 0.51 | MCAODC_27680 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Escherichia coli ECOR27 | 0.68 | NOLOHH_00795 | | Bifunctional protein FolD | 0.53 | NOLOHH_01400 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.68 | GFF4447 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.48 | GFF4318 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Pantoea agglomerans CFBP13505 P0401 | 0.68 | PagCFBP13505_RS10890 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.54 | PagCFBP13505_RS10425 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Escherichia coli ECRC100 | 0.68 | OKFHMN_07805 | | Bifunctional protein FolD | 0.51 | OKFHMN_08455 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Escherichia coli Nissle 1917 | 0.68 | ECOLIN_RS03065 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.51 | ECOLIN_RS02505 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Escherichia coli ECRC99 | 0.68 | KEDOAH_20165 | | Bifunctional protein FolD | 0.51 | KEDOAH_19510 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Escherichia coli BL21 | 0.68 | ECD_00479 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.53 | ECD_00362 | | fused diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase | — | — |
| Escherichia coli ECOR38 | 0.67 | HEPCGN_06445 | | Bifunctional protein FolD | 0.52 | HEPCGN_07080 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Escherichia coli ECRC62 | 0.67 | BNILDI_22225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.53 | BNILDI_22815 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Erwinia amylovora T8 | 0.67 | OLJFJH_17600 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.54 | OLJFJH_18090 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Dickeya dadantii 3937 | 0.67 | DDA3937_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.50 | DDA3937_RS05505 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pectobacterium carotovorum WPP14 | 0.67 | HER17_RS06505 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.55 | HER17_RS15960 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Shewanella loihica PV-4 | 0.67 | Shew_2510 | | methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.52 | Shew_1187 | | riboflavin biosynthesis protein RibD (RefSeq) | — | — |
| Alteromonas macleodii MIT1002 | 0.66 | MIT1002_02770 | | hypothetical protein | 0.44 | MIT1002_02700 | | Riboflavin biosynthesis protein RibD | — | — |
| Dickeya dianthicola 67-19 | 0.66 | HGI48_RS15155 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.50 | HGI48_RS05565 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Shewanella oneidensis MR-1 | 0.66 | SO1792 | folD | methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase (NCBI ptt file) | 0.50 | SO3469 | ribD | riboflavin biosynthesis protein RibD (NCBI ptt file) | — | — |
| Erwinia tracheiphila SCR3 | 0.66 | LU632_RS15195 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.51 | LU632_RS18595 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Erwinia tracheiphila HP pepo 2.2 | 0.66 | IJEDHG_00975 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.51 | IJEDHG_25995 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Dickeya dianthicola ME23 | 0.66 | DZA65_RS15960 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.50 | DZA65_RS05890 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas simiae WCS417 | 0.62 | PS417_17265 | | methenyltetrahydrofolate cyclohydrolase | 0.44 | PS417_25265 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase | — | — |
| Pseudomonas sp. S08-1 | 0.62 | OH686_03670 | | Methenyltetrahydrofolate cyclohydrolase / Methylenetetrahydrofolate dehydrogenase (NADP+) | 0.46 | OH686_15695 | | riboflavin biosynthesis protein RibD | — | — |
| Pseudomonas aeruginosa PUPa3 | 0.62 | DQ20_RS54755 | folD;go_function=methylenetetrahydrofolate | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | DQ20_RS47900 | ribD;go_function=5-amino-6-(5-phosphoribosylamino)uracil | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas aeruginosa PA14 | 0.62 | IKLFDK_08690 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | IKLFDK_20910 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas orientalis W4I3 | 0.62 | QF045_RS18930 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.46 | QF045_RS27230 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas aeruginosa MRSN321 | 0.62 | DY961_RS20675 | folD;go_function=methylenetetrahydrofolate | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | DY961_RS27745 | ribD;go_function=5-amino-6-(5-phosphoribosylamino)uracil | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas fluorescens GW456-L13 | 0.62 | PfGW456L13_2550 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.47 | PfGW456L13_1313 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Pseudomonas sp. RS175 | 0.61 | PFR28_01223 | | Bifunctional protein FolD protein | 0.48 | PFR28_03949 | | Riboflavin biosynthesis protein RibD | — | — |
| Pseudomonas fluorescens FW300-N2C3 | 0.61 | AO356_01775 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.48 | AO356_14930 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase | — | — |
| Marinobacter adhaerens HP15 | 0.61 | HP15_2187 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.45 | HP15_492 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase | — | — |
| Pseudomonas fluorescens SBW25 | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | PFLU_RS26900 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas putida KT2440 | 0.61 | PP_2265 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.46 | PP_0514 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase | — | — |
| Pseudomonas fluorescens FW300-N2E2 | 0.61 | Pf6N2E2_2221 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.48 | Pf6N2E2_4919 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Pseudomonas lactucae CFBP13502 | 0.61 | GEMAOFIL_03749 | | Bifunctional protein FolD protein | 0.47 | GEMAOFIL_05158 | | Riboflavin biosynthesis protein RibD | — | — |
| Pseudomonas fluorescens SBW25-INTG | 0.61 | PFLU_RS19200 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | PFLU_RS26900 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas fluorescens FW300-N1B4 | 0.61 | Pf1N1B4_3943 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.47 | Pf1N1B4_2649 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Pseudomonas sp. SVBP6 | 0.61 | COO64_RS19115 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.47 | COO64_RS15890 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas sp. DMC3 | 0.61 | GFF1441 | | Bifunctional protein FolD protein | 0.47 | GFF3827 | | Riboflavin biosynthesis protein RibD | — | — |
| Pseudomonas sp. BP01 | 0.61 | JOY50_RS25950 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.46 | JOY50_RS20125 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Pseudomonas fluorescens FW300-N2E3 | 0.61 | AO353_20145 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.48 | AO353_06715 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase | — | — |
| Pseudomonas segetis P6 | 0.60 | MPMX49_02256 | | Bifunctional protein FolD protein | 0.47 | MPMX49_00990 | | Riboflavin biosynthesis protein RibD | — | — |
| Pseudomonas syringae pv. syringae B728a ΔmexB | 0.60 | Psyr_1743 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.46 | Psyr_4462 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase | — | — |
| Pseudomonas syringae pv. syringae B728a | 0.60 | Psyr_1743 | | methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.46 | Psyr_4462 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase | — | — |
| Pseudomonas stutzeri RCH2 | 0.58 | Psest_2301 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.47 | Psest_3552 | | riboflavin biosynthesis protein RibD | — | — |
| Kangiella aquimarina DSM 16071 | 0.57 | B158DRAFT_1028 | | methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)/5,10-methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.43 | B158DRAFT_1910 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) | — | — |
| Rhodanobacter sp000427505 FW510-R12 | 0.56 | LRK53_RS11165 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.41 | LRK53_RS05400 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Rhodanobacter denitrificans FW104-10B01 | 0.55 | LRK54_RS00100 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.41 | LRK54_RS04610 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Rhodanobacter denitrificans MT42 | 0.55 | LRK55_RS18095 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.41 | LRK55_RS04385 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Rhodanobacter sp. FW510-T8 | 0.54 | OKGIIK_07100 | folD | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.41 | OKGIIK_11430 | ribD | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Dyella japonica UNC79MFTsu3.2 | 0.54 | ABZR86_RS05415 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.40 | ABZR86_RS10705 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Lysobacter sp. OAE881 | 0.52 | ABIE51_RS09470 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.45 | ABIE51_RS04630 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Xanthomonas campestris pv. campestris strain 8004 | 0.51 | Xcc-8004.2390.1 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.43 | Xcc-8004.4395.1 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Castellaniella sp019104865 MT123 | 0.48 | ABCV34_RS04175 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.30 | ABCV34_RS10545 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Herbaspirillum seropedicae SmR1 | 0.46 | HSERO_RS07295 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.39 | HSERO_RS18235 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase | — | — |
| Cupriavidus basilensis FW507-4G11 | 0.46 | RR42_RS07345 | | methenyltetrahydrofolate cyclohydrolase | 0.41 | RR42_RS15555 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase | — | — |
| Desulfovibrio vulgaris Hildenborough JW710 | 0.46 | DVU0323 | folD | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase (TIGR) | 0.27 | DVU1201 | ribD | riboflavin biosynthesis protein RibD (TIGR) | — | — |
| Dechlorosoma suillum PS | 0.46 | Dsui_0093 | | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase | 0.37 | Dsui_1267 | | riboflavin biosynthesis protein RibD | — | — |
| Hydrogenophaga sp. GW460-11-11-14-LB1 | 0.45 | GFF4894 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.31 | GFF5160 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Ralstonia solanacearum PSI07 | 0.45 | RPSI07_RS15800 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.42 | RPSI07_RS20395 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Ralstonia solanacearum UW163 | 0.45 | UW163_RS14995 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.42 | UW163_RS00740 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Ralstonia solanacearum IBSBF1503 | 0.45 | RALBFv3_RS01685 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.42 | RALBFv3_RS12825 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Ralstonia sp. UNC404CL21Col | 0.45 | ABZR87_RS13485 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.43 | ABZR87_RS08885 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Ralstonia solanacearum GMI1000 | 0.45 | RS_RS08040 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.42 | RS_RS03600 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Magnetospirillum magneticum AMB-1 | 0.45 | AMB_RS22130 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | 0.31 | AMB_RS11825 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Acidovorax sp. GW101-3H11 | 0.45 | Ac3H11_4096 | | Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) / Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | 0.30 | Ac3H11_1461 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Variovorax sp. SCN45 | 0.44 | GFF964 | | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) / Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.35 | GFF568 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Variovorax sp. OAS795 | 0.44 | ABID97_RS14085 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.38 | ABID97_RS17935 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Echinicola vietnamensis KMM 6221, DSM 17526 | 0.43 | Echvi_4643 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.28 | Echvi_0964 | | riboflavin biosynthesis protein RibD | — | — |
| Synechococcus elongatus PCC 7942 | 0.43 | Synpcc7942_0777 | folD | Methenyltetrahydrofolate cyclohydrolase | 0.33 | Synpcc7942_0203 | ribD | 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase | — | — |
| Paraburkholderia sabiae LMG 24235 | 0.43 | QEN71_RS05700 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.42 | QEN71_RS03300 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Desulfovibrio vulgaris Miyazaki F | 0.43 | DvMF_1809 | | Methenyltetrahydrofolate cyclohydrolase (RefSeq) | 0.24 | DvMF_3095 | | riboflavin biosynthesis protein RibD (RefSeq) | — | — |
| Pontibacter actiniarum KMM 6156, DSM 19842 | 0.43 | CA264_07145 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.27 | CA264_17890 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase | — | — |
| Synechocystis sp000284455 PCC 6803 | 0.43 | SGL_RS13155 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.30 | SGL_RS13965 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Phaeobacter inhibens DSM 17395 | 0.43 | PGA1_c06010 | | bifunctional protein FolD | 0.33 | PGA1_c08870 | | riboflavin biosynthesis protein RibD | — | — |
| Burkholderia phytofirmans PsJN | 0.42 | BPHYT_RS12865 | | bifunctional protein FolD | 0.40 | BPHYT_RS15380 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase | — | — |
| Paraburkholderia graminis OAS925 | 0.42 | ABIE53_002796 | | methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolate cyclohydrolase | 0.40 | ABIE53_003242 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase | — | — |
| Xanthobacter sp. DMC5 | 0.42 | GFF1063 | | Bifunctional protein FolD protein | 0.24 | GFF577 | | Riboflavin biosynthesis protein RibD | — | — |
| Paraburkholderia bryophila 376MFSha3.1 | 0.42 | H281DRAFT_00463 | | methenyltetrahydrofolate cyclohydrolase /5,10-methylenetetrahydrofolate dehydrogenase (NADP+) | 0.40 | H281DRAFT_04019 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase | — | — |
| Rhodospirillum rubrum S1H | 0.42 | Rru_A0557 | | Methenyltetrahydrofolate cyclohydrolase (NCBI) | 0.27 | Rru_A1825 | | bifunctional deaminase-reductase (NCBI) | — | — |
| Parabacteroides merdae CL09T00C40 | 0.42 | HMPREF1078_RS14700 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.28 | HMPREF1078_RS11285 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Bosea sp. OAE506 | 0.42 | ABIE41_RS08995 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.23 | ABIE41_RS19760 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Sphingomonas koreensis DSMZ 15582 | 0.42 | Ga0059261_2527 | | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase | 0.26 | Ga0059261_2336 | | diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) | — | — |
| Cellulophaga baltica 18 | 0.41 | M666_RS00795 | | bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase | 0.24 | M666_RS17750 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Phocaeicola dorei CL03T12C01 | 0.41 | ABI39_RS10870 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.26 | ABI39_RS07065 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Phocaeicola vulgatus CL09T03C04 | 0.41 | HMPREF1058_RS15075 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.27 | HMPREF1058_RS09615 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Bacteroides thetaiotaomicron VPI-5482 | 0.41 | BT1607 | | methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase (NCBI ptt file) | 0.27 | BT3728 | | riboflavin biosynthesis protein ribD (NCBI ptt file) | — | — |
| Bacteroides ovatus ATCC 8483 | 0.41 | BACOVA_04344 | | tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein | 0.27 | BACOVA_03546 | | riboflavin biosynthesis protein RibD | — | — |
| Azospirillum brasilense Sp245 | 0.40 | AZOBR_RS00650 | | 5 10-methylene-tetrahydrofolate dehydrogenase | 0.28 | AZOBR_RS10025 | | 5-amino-6-(5-phosphoribosylamino)uracil reductase | — | — |
| Bacteroides stercoris CC31F | 0.40 | HMPREF1181_RS11305 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.24 | HMPREF1181_RS03385 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Azospirillum sp. SherDot2 | 0.40 | MPMX19_02743 | | Bifunctional protein FolD protein | 0.31 | MPMX19_00736 | | Riboflavin biosynthesis protein RibD | — | — |
| Rhodopseudomonas palustris CGA009 | 0.39 | TX73_002145 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.31 | TX73_014125 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Mucilaginibacter yixingensis YX-36 DSM 26809 | 0.39 | ABZR88_RS09400 | | bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase | 0.26 | ABZR88_RS10210 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Sphingobium sp. HT1-2 | 0.39 | GFF2785 | | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) / Methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) | 0.28 | GFF3255 | | Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) | — | — |
| Sinorhizobium meliloti 1021 | 0.38 | SMc03059 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase | 0.26 | SMc01772 | | riboflavin biosynthesis protein | — | — |
| Pedobacter sp. GW460-11-11-14-LB5 | 0.38 | CA265_RS08950 | | bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase | 0.24 | CA265_RS09530 | | riboflavin biosynthesis protein RibD | — | — |
| Dinoroseobacter shibae DFL-12 | 0.37 | Dshi_1285 | | Methylenetetrahydrofolate dehydrogenase (NADP(+)) (RefSeq) | 0.25 | Dshi_2256 | | riboflavin biosynthesis protein RibD (RefSeq) | — | — |
| Agrobacterium fabrum C58 | 0.36 | Atu0589 | | methylenetetrahydrofolate dehydrogenase | 0.24 | Atu8148 | | bifunctional riboflavin deaminase-reductase | — | — |
| Acinetobacter radioresistens SK82 | 0.35 | MPMX26_00777 | | Bifunctional protein FolD protein | 0.44 | MPMX26_00152 | | Riboflavin biosynthesis protein RibD | — | — |
| Fusobacterium nucleatum SB010 | 0.35 | HUW76_09060 | | bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase | 0.32 | HUW76_09285 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Acinetobacter baumannii LAC-4 | 0.35 | RR41_RS04225 | | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD | 0.42 | RR41_RS17855 | | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | — | — |
| Mycobacterium tuberculosis H37Rv | 0.34 | Rv3356c | | Probable bifunctional protein FolD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase | 0.24 | Rv1409 | | Probable bifunctional riboflavin biosynthesis protein RibG : diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase) | — | — |
Not shown: 5 genomes with orthologs for CSW01_09720 only; 1 genomes with orthologs for CSW01_11560 only