| Organism | Ratio1 | Gene1 | Name1 | Description1 | Ratio2 | Gene2 | Name2 | Description2 | Cofit | Rank |
| Vibrio cholerae E7946 ATCC 55056 | 1.0 | CSW01_08100 | | homoserine O-succinyltransferase | 1.0 | CSW01_01280 | | GDP-mannose 4,6-dehydratase | 0.77 | 20 |
| Dickeya dadantii 3937 | 0.66 | DDA3937_RS19065 | | homoserine O-succinyltransferase | 0.87 | DDA3937_RS18665 | | GDP-mannose 4,6-dehydratase | low | > 74 |
| Dickeya dianthicola 67-19 | 0.66 | HGI48_RS19155 | | homoserine O-succinyltransferase | 0.87 | HGI48_RS18595 | | GDP-mannose 4,6-dehydratase | low | > 71 |
| Dickeya dianthicola ME23 | 0.66 | DZA65_RS20275 | | homoserine O-succinyltransferase | 0.87 | DZA65_RS19730 | | GDP-mannose 4,6-dehydratase | low | > 75 |
| Pectobacterium carotovorum WPP14 | 0.66 | HER17_RS02285 | | homoserine O-succinyltransferase | 0.78 | HER17_RS14540 | | GDP-mannose 4,6-dehydratase | low | > 75 |
| Rahnella sp. WP5 | 0.66 | EX31_RS11735 | | homoserine O-succinyltransferase | 0.52 | EX31_RS02865 | | GDP-mannose 4,6-dehydratase | low | > 89 |
| Pantoea sp. MT58 | 0.65 | IAI47_18015 | | homoserine O-succinyltransferase | 0.11 | IAI47_18500 | | dTDP-glucose 4,6-dehydratase | — | — |
| Escherichia coli ECRC98 | 0.64 | JDDGAC_16900 | metA | homoserine O-succinyltransferase | 0.83 | JDDGAC_28550 | | GDP-mannose 4,6-dehydratase | — | — |
| Escherichia coli ECOR38 | 0.64 | HEPCGN_11915 | metA | homoserine O-succinyltransferase | 0.83 | HEPCGN_03045 | | GDP-mannose 4,6-dehydratase | low | > 88 |
| Escherichia coli ECRC99 | 0.64 | KEDOAH_14885 | metA | homoserine O-succinyltransferase | 0.83 | KEDOAH_03710 | | GDP-mannose 4,6-dehydratase | — | — |
| Escherichia coli ECRC101 | 0.64 | MCAODC_03775 | metA | homoserine O-succinyltransferase | 0.83 | MCAODC_20500 | | GDP-mannose 4,6-dehydratase | — | — |
| Erwinia amylovora T8 | 0.64 | OLJFJH_03650 | | homoserine O-succinyltransferase | 0.10 | OLJFJH_12090 | | dTDP-glucose 4 6-dehydratase | — | — |
| Escherichia coli ECRC102 | 0.64 | NIAGMN_11025 | metA | homoserine O-succinyltransferase | 0.83 | NIAGMN_22385 | | GDP-mannose 4,6-dehydratase | low | > 80 |
| Escherichia coli ECRC100 | 0.64 | OKFHMN_13275 | metA | homoserine O-succinyltransferase | 0.83 | OKFHMN_24440 | | GDP-mannose 4,6-dehydratase | — | — |
| Escherichia coli Nissle 1917 | 0.64 | ECOLIN_RS25515 | | homoserine O-succinyltransferase | 0.82 | ECOLIN_RS12095 | | GDP-mannose 4,6-dehydratase | — | — |
| Escherichia coli ECRC62 | 0.64 | BNILDI_06100 | metA | homoserine O-succinyltransferase | 0.83 | BNILDI_14585 | | GDP-mannose 4,6-dehydratase | low | > 75 |
| Escherichia fergusonii Becca | 0.64 | EFB2_04597 | | Homoserine O-succinyltransferase | 0.83 | EFB2_01801 | | GDP-mannose 4,6-dehydratase | low | > 86 |
| Escherichia coli BW25113 | 0.64 | b4013 | metA | homoserine O-succinyltransferase (NCBI) | 0.83 | b2053 | gmd | GDP-D-mannose dehydratase, NAD(P)-binding (NCBI) | low | > 76 |
| Escherichia coli ECOR27 | 0.64 | NOLOHH_05420 | metA | homoserine O-succinyltransferase | 0.83 | NOLOHH_15675 | | GDP-mannose 4,6-dehydratase | low | > 76 |
| Enterobacter asburiae PDN3 | 0.64 | EX28DRAFT_4331 | | homoserine O-succinyltransferase (EC 2.3.1.46) | 0.83 | EX28DRAFT_0502 | | GDP-mannose 4,6-dehydratase | low | > 76 |
| Pantoea agglomerans CFBP13505 P0401 | 0.64 | PagCFBP13505_RS22330 | | homoserine O-succinyltransferase | 0.46 | PagCFBP13505_RS01140 | | GDP-mannose 4,6-dehydratase | 0.67 | 39 |
| Enterobacter sp. TBS_079 | 0.64 | MPMX20_00230 | | Homoserine O-succinyltransferase | 0.82 | MPMX20_03035 | | GDP-mannose 4,6-dehydratase | low | > 85 |
| Escherichia coli HS(pFamp)R (ATCC 700891) | 0.64 | OHPLBJKB_04037 | | Homoserine O-succinyltransferase | 0.10 | OHPLBJKB_04266 | | dTDP-glucose 4,6-dehydratase 2 | low | > 74 |
| Escherichia coli BL21 | 0.64 | ECD_03885 | | homoserine O-transsuccinylase | 0.83 | ECD_01959 | | GDP-D-mannose dehydratase, NAD(P)-binding | low | > 61 |
| Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 | 0.64 | GFF1350 | | Homoserine O-succinyltransferase (EC 2.3.1.46) | 0.83 | GFF3875 | | GDP-mannose 4,6-dehydratase (EC 4.2.1.47) | low | > 78 |
| Bacteroides thetaiotaomicron VPI-5482 | 0.52 | BT2413 | | homoserine O-succinyltransferase (NCBI ptt file) | 0.60 | BT1224 | | GDP-mannose 4,6-dehydratase (NCBI ptt file) | — | — |
| Phocaeicola dorei CL03T12C01 | 0.52 | ABI39_RS10360 | | homoserine O-succinyltransferase | 0.61 | ABI39_RS20410 | | GDP-mannose 4,6-dehydratase | low | > 72 |
| Phocaeicola vulgatus CL09T03C04 | 0.52 | HMPREF1058_RS14680 | | homoserine O-succinyltransferase | 0.61 | HMPREF1058_RS06615 | | GDP-mannose 4,6-dehydratase | low | > 67 |
| Bacteroides ovatus ATCC 8483 | 0.51 | BACOVA_03007 | | homoserine O-succinyltransferase | 0.60 | BACOVA_00511 | | GDP-mannose 4,6-dehydratase | 0.80 | 71 |
| Bacteroides stercoris CC31F | 0.50 | HMPREF1181_RS00105 | | homoserine O-succinyltransferase | 0.60 | HMPREF1181_RS12530 | | GDP-mannose 4,6-dehydratase | low | > 56 |
| Parabacteroides merdae CL09T00C40 | 0.49 | HMPREF1078_RS10000 | | homoserine O-succinyltransferase | 0.63 | HMPREF1078_RS00185 | | GDP-mannose 4,6-dehydratase | low | > 61 |
| Agrobacterium fabrum C58 | 0.42 | Atu2718 | | homoserine O-succinyltransferase | 0.59 | Atu4789 | | GDP-mannose 4,6-dehydratase | low | > 89 |
| Phaeobacter inhibens DSM 17395 | 0.41 | PGA1_c14560 | | homoserine O-succinyltransferase MetA | 0.81 | PGA1_65p00310 | | GDP-mannose 4,6-dehydratase Gmd | low | > 62 |
| Synechococcus elongatus PCC 7942 | 0.40 | Synpcc7942_0371 | metA | homoserine O-succinyltransferase | 0.71 | Synpcc7942_1342 | gmd | GDP-mannose 4,6-dehydratase | — | — |
| Dinoroseobacter shibae DFL-12 | 0.40 | Dshi_1593 | | Homoserine O-succinyltransferase (RefSeq) | 0.63 | Dshi_4139 | | GDP-mannose 4,6-dehydratase (RefSeq) | — | — |
| Sphingobium sp. HT1-2 | 0.40 | GFF1541 | | Homoserine O-succinyltransferase (EC 2.3.1.46) | 0.11 | GFF4227 | | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) | low | > 95 |
| Azospirillum brasilense Sp245 | 0.40 | AZOBR_RS14010 | | homoserine O-succinyltransferase | 0.44 | AZOBR_RS33465 | | GDP-mannose 4 6-dehydratase | low | > 97 |
| Paraburkholderia sabiae LMG 24235 | 0.34 | QEN71_RS42530 | | homoserine O-succinyltransferase | 0.70 | QEN71_RS26360 | | GDP-mannose 4,6-dehydratase | low | > 153 |
Not shown: 13 genomes with orthologs for CSW01_08100 only; 52 genomes with orthologs for CSW01_01280 only