Conservation of cofitness between Atu3290 and Atu4098 in Agrobacterium fabrum C58

94 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Agrobacterium fabrum C58 1.0 Atu3290 phosphomethylpyrimidine kinase 1.0 Atu4098 quinolinate synthetase 0.86 5
Sinorhizobium meliloti 1021 0.59 SM_b20962 phoshomethylpyrimidine kinase 0.56 SMc02601 quinolinate synthetase low > 103
Xanthobacter sp. DMC5 0.55 GFF1029 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.69 GFF1847 Quinolinate synthase A — —
Rhodopseudomonas palustris CGA009 0.53 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 TX73_005425 quinolinate synthase NadA — —
Enterobacter asburiae PDN3 0.51 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 EX28DRAFT_2245 quinolinate synthetase (EC 2.5.1.72) 0.70 1
Pectobacterium carotovorum WPP14 0.50 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 HER17_RS14820 quinolinate synthase NadA 0.78 44
Escherichia coli ECRC62 0.50 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 BNILDI_21185 nadA quinolinate synthase NadA 0.65 34
Escherichia coli HS(pFamp)R (ATCC 700891) 0.50 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.23 OHPLBJKB_02963 Quinolinate synthase A low > 74
Escherichia coli ECRC100 0.50 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 OKFHMN_06760 nadA quinolinate synthase NadA 0.87 17
Escherichia coli ECRC102 0.50 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 NIAGMN_04810 nadA quinolinate synthase NadA low > 80
Escherichia coli ECOR27 0.50 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 NOLOHH_23190 nadA quinolinate synthase NadA low > 76
Klebsiella michiganensis M5al 0.50 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 BWI76_RS08580 quinolinate synthetase 0.20 17
Escherichia coli ECRC101 0.50 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 MCAODC_25980 nadA quinolinate synthase NadA 0.60 3
Escherichia coli ECRC99 0.50 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 KEDOAH_21205 nadA quinolinate synthase NadA — —
Escherichia coli ECRC98 0.50 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 JDDGAC_10415 nadA quinolinate synthase NadA low > 87
Escherichia coli BW25113 0.50 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.24 b0750 nadA quinolinate synthetase (NCBI) 0.61 11
Enterobacter sp. TBS_079 0.50 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.22 MPMX20_01377 Quinolinate synthase A low > 85
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.50 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.23 GFF4 Quinolinate synthetase (EC 2.5.1.72) — —
Escherichia coli ECOR38 0.50 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 HEPCGN_01515 nadA quinolinate synthase NadA 0.74 27
Escherichia coli BL21 0.50 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.24 ECD_00703 quinolinate synthase, subunit A 0.48 4
Escherichia fergusonii Becca 0.50 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.23 EFB2_03356 Quinolinate synthase A low > 86
Rahnella sp. WP5 0.50 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 EX31_RS23525 quinolinate synthase NadA low > 89
Serratia liquefaciens MT49 0.50 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 IAI46_06380 quinolinate synthase NadA low > 86
Klebsiella pneumoniae MKP103 0.49 KDGMDA_26425 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 KDGMDA_16840 quinolinate synthase NadA low > 95
Escherichia coli Nissle 1917 0.49 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 ECOLIN_RS03990 quinolinate synthase NadA — —
Dickeya dadantii 3937 0.49 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.22 DDA3937_RS06545 quinolinate synthase NadA 0.74 17
Pantoea agglomerans CFBP13505 P0401 0.48 PagCFBP13505_RS00915 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 PagCFBP13505_RS03665 quinolinate synthase NadA low > 74
Dickeya dianthicola 67-19 0.48 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 HGI48_RS06595 quinolinate synthase NadA 0.78 31
Dickeya dianthicola ME23 0.48 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.21 DZA65_RS06945 quinolinate synthase NadA 0.82 13
Pantoea sp. MT58 0.47 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 IAI47_13635 quinolinate synthase NadA low > 76
Paraburkholderia sabiae LMG 24235 0.46 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 QEN71_RS03060 quinolinate synthase NadA — —
Parabacteroides merdae CL09T00C40 0.45 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.33 HMPREF1078_RS06555 quinolinate synthase NadA — —
Burkholderia phytofirmans PsJN 0.45 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.23 BPHYT_RS15650 quinolinate synthetase — —
Vibrio cholerae E7946 ATCC 55056 0.44 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 CSW01_09180 quinolinate synthase low > 62
Bacteroides thetaiotaomicron VPI-5482 0.44 BT0790 phosphomethylpyrimidine kinase (NCBI ptt file) 0.34 BT3164 quinolinate synthetase A (NCBI ptt file) 0.43 18
Rhizobium sp. OAE497 0.43 ABIE40_RS25930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.83 ABIE40_RS23255 quinolinate synthase NadA low > 107
Paraburkholderia graminis OAS925 0.43 ABIE53_002529 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.24 ABIE53_003294 quinolinate synthase — —
Phocaeicola vulgatus CL09T03C04 0.43 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 HMPREF1058_RS11230 quinolinate synthase NadA — —
Phocaeicola dorei CL03T12C01 0.42 ABI39_RS20615 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 ABI39_RS05755 quinolinate synthase NadA — —
Bacteroides ovatus ATCC 8483 0.42 BACOVA_02530 phosphomethylpyrimidine kinase 0.34 BACOVA_02839 quinolinate synthetase complex, A subunit 0.79 9
Bacteroides stercoris CC31F 0.42 HMPREF1181_RS14705 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 HMPREF1181_RS01920 quinolinate synthase NadA — —
Castellaniella sp019104865 MT123 0.41 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.25 ABCV34_RS03700 quinolinate synthase NadA — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.25 GFF1216 Quinolinate synthetase (EC 2.5.1.72) low > 90
Pedobacter sp. GW460-11-11-14-LB5 0.40 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.35 CA265_RS21180 quinolinate synthase — —
Acidovorax sp. GW101-3H11 0.39 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.25 Ac3H11_3837 Quinolinate synthetase (EC 2.5.1.72) — —
Rhodospirillum rubrum S1H 0.38 Rru_A1102 Phosphomethylpyrimidine kinase (NCBI) 0.57 Rru_A1434 Quinolinate synthetase A (NCBI) — —
Rhodanobacter sp000427505 FW510-R12 0.38 LRK53_RS03825 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.53 LRK53_RS14710 quinolinate synthase NadA low > 59
Mucilaginibacter yixingensis YX-36 DSM 26809 0.36 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.36 ABZR88_RS20650 quinolinate synthase NadA — —
Bifidobacterium breve UCC2003 0.36 BBR_RS17215 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 BBR_RS16730 quinolinate synthase NadA low > 34
Desulfovibrio vulgaris Hildenborough JW710 0.36 DVU0931 thiD phosphomethylpyrimidine kinase (TIGR) 0.18 DVU1808 nadA quinolinate synthetase complex, subunit A (TIGR) — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 ABID97_RS07415 quinolinate synthase NadA — —
Azospirillum brasilense Sp245 0.35 AZOBR_RS07045 phosphomethylpyrimidine kinase 0.63 AZOBR_RS18690 quinolinate synthetase — —
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 UW163_RS08935 quinolinate synthase NadA — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.24 RALBFv3_RS04735 quinolinate synthase NadA — —
Ralstonia sp. UNC404CL21Col 0.35 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.26 ABZR87_RS00355 quinolinate synthase NadA — —
Ralstonia solanacearum GMI1000 0.34 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.26 RS_RS12295 quinolinate synthase — —
Caulobacter crescentus NA1000 0.34 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.55 CCNA_03006 quinolinate synthetase A — —
Caulobacter crescentus NA1000 Δfur 0.34 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.55 CCNA_03006 quinolinate synthetase A — —
Ralstonia solanacearum PSI07 0.34 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.25 RPSI07_RS12650 quinolinate synthase NadA — —
Azospirillum sp. SherDot2 0.33 MPMX19_06182 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.61 MPMX19_05670 Quinolinate synthase A — —
Brevundimonas sp. GW460-12-10-14-LB2 0.33 A4249_RS15985 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.54 A4249_RS00620 quinolinate synthase NadA — —
Sphingobium sp. HT1-2 0.33 GFF2573 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.31 GFF246 Quinolinate synthetase (EC 2.5.1.72) low > 95
Fusobacterium nucleatum SB010 0.33 HUW76_10300 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.25 HUW76_10740 quinolinate synthase NadA low > 35
Desulfovibrio vulgaris Miyazaki F 0.32 DvMF_1376 phosphomethylpyrimidine kinase (RefSeq) 0.19 DvMF_0525 quinolinate synthetase (RefSeq) — —
Cupriavidus basilensis FW507-4G11 0.31 RR42_RS01370 phosphomethylpyrimidine kinase 0.24 RR42_RS17020 quinolinate synthetase — —
Synechococcus elongatus PCC 7942 0.30 Synpcc7942_2379 thiD phosphomethylpyrimidine kinase 0.32 Synpcc7942_1448 nadA quinolinate synthetase low > 38
Magnetospirillum magneticum AMB-1 0.29 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.30 AMB_RS19660 quinolinate synthase NadA — —
Rhodanobacter sp. FW510-T8 0.29 OKGIIK_03835 Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.52 OKGIIK_00930 nadA quinolinate synthase NadA low > 53
Acinetobacter radioresistens SK82 0.28 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.24 MPMX26_02602 Quinolinate synthase A — —
Acinetobacter baumannii LAC-4 0.28 RR41_RS15160 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.24 RR41_RS15700 quinolinate synthase NadA — —
Pseudomonas aeruginosa PA14 0.27 IKLFDK_20515 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.23 IKLFDK_04555 quinolinate synthase NadA low > 100
Dechlorosoma suillum PS 0.27 Dsui_0662 phosphomethylpyrimidine kinase 0.21 Dsui_1043 quinolinate synthetase complex, A subunit — —
Sphingomonas koreensis DSMZ 15582 0.27 Ga0059261_1961 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.31 Ga0059261_0051 quinolinate synthetase (EC 2.5.1.72) — —
Pseudomonas simiae WCS417 0.27 PS417_24600 hydrogenase 0.22 PS417_22385 quinolinate synthase A low > 88
Pseudomonas putida KT2440 0.27 PP_4782 Phosphomethylpyrimidine kinase 0.23 PP_1231 quinolinate synthase [4Fe-4S] cluster subunit 0.73 5
Pseudomonas fluorescens FW300-N2C3 0.27 AO356_15435 hydrogenase 0.23 AO356_18145 quinolinate synthase A low > 104
Pseudomonas sp. BP01 0.27 JOY50_RS21745 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.23 JOY50_RS01740 nadA quinolinate synthase NadA low > 84
Pseudomonas sp. SVBP6 0.26 COO64_RS15485 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.23 COO64_RS20215 nadA quinolinate synthase NadA 0.58 90
Pseudomonas sp. S08-1 0.26 OH686_09185 Hydroxymethylpyrimidine phosphate kinase ThiD 0.24 OH686_19190 quinolinate synthetase complex, A subunit 0.78 7
Pseudomonas fluorescens SBW25 0.26 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.22 PFLU_RS24025 quinolinate synthase NadA 0.74 77
Pseudomonas fluorescens FW300-N2E3 0.26 AO353_06350 hydrogenase 0.22 AO353_03525 quinolinate synthase A 0.39 25
Pseudomonas fluorescens SBW25-INTG 0.26 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.22 PFLU_RS24025 quinolinate synthase NadA 0.51 7
Pseudomonas fluorescens GW456-L13 0.26 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.23 PfGW456L13_1863 Quinolinate synthetase (EC 2.5.1.72) low > 87
Mycobacterium tuberculosis H37Rv 0.26 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) 0.31 Rv1594 Probable quinolinate synthetase NadA — —
Pseudomonas sp. DMC3 0.26 GFF3905 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.23 GFF5174 Quinolinate synthase A 0.63 29
Pseudomonas stutzeri RCH2 0.26 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.24 Psest_1509 quinolinate synthetase complex, A subunit 0.46 6
Pseudomonas syringae pv. syringae B728a ΔmexB 0.26 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.24 Psyr_1542 quinolinate synthetase low > 86
Pseudomonas syringae pv. syringae B728a 0.26 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.24 Psyr_1542 quinolinate synthetase low > 86
Pseudomonas segetis P6 0.25 MPMX49_01077 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.23 MPMX49_01696 Quinolinate synthase A — —
Pseudomonas sp. RS175 0.24 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.23 PFR28_03388 Quinolinate synthase A 0.69 6
Herbaspirillum seropedicae SmR1 0.24 HSERO_RS02135 phosphomethylpyrimidine kinase 0.24 HSERO_RS11065 quinolinate synthetase low > 78
Pseudomonas fluorescens FW300-N1B4 0.23 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.23 Pf1N1B4_626 Quinolinate synthetase (EC 2.5.1.72) 0.30 21
Pseudomonas fluorescens FW300-N2E2 0.23 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.23 Pf6N2E2_5553 Quinolinate synthetase (EC 2.5.1.72) low > 103
Pseudomonas lactucae CFBP13502 0.23 GEMAOFIL_05068 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.22 GEMAOFIL_04613 Quinolinate synthase A low > 93
Phaeobacter inhibens DSM 17395 0.19 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.53 PGA1_c27790 quinolinate synthetase A 0.25 61

Not shown: 13 genomes with orthologs for Atu3290 only; 13 genomes with orthologs for Atu4098 only