Conservation of cofitness between Atu3290 and Atu3997 in Agrobacterium fabrum C58

94 genomes with putative orthologs of both genes

Organism Ratio1 Gene1 Name1 Description1 Ratio2 Gene2 Name2 Description2 Cofit Rank
Agrobacterium fabrum C58 1.0 Atu3290 phosphomethylpyrimidine kinase 1.0 Atu3997 biotin synthetase 0.86 3
Xanthobacter sp. DMC5 0.55 GFF1029 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.49 GFF256 Biotin synthase — —
Rhodopseudomonas palustris CGA009 0.53 TX73_020570 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 TX73_010535 biotin synthase BioB — —
Enterobacter asburiae PDN3 0.51 EX28DRAFT_0469 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.60 EX28DRAFT_2216 biotin synthase (EC 2.8.1.6) low > 76
Pectobacterium carotovorum WPP14 0.50 HER17_RS06265 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 HER17_RS13460 biotin synthase BioB low > 75
Escherichia coli BW25113 0.50 b2103 thiD phosphomethylpyrimidine kinase (NCBI) 0.61 b0775 bioB biotin synthase (NCBI) low > 76
Escherichia coli ECRC98 0.50 JDDGAC_28185 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 JDDGAC_10035 bioB biotin synthase BioB low > 87
Escherichia coli HS(pFamp)R (ATCC 700891) 0.50 OHPLBJKB_01607 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.61 OHPLBJKB_02938 Biotin synthase low > 74
Escherichia coli ECRC102 0.50 NIAGMN_22020 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 NIAGMN_04445 bioB biotin synthase BioB low > 80
Escherichia coli ECRC99 0.50 KEDOAH_04075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 KEDOAH_21510 bioB biotin synthase BioB — —
Escherichia coli ECRC62 0.50 BNILDI_14330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 BNILDI_21040 bioB biotin synthase BioB low > 75
Escherichia coli ECOR27 0.50 NOLOHH_15415 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 NOLOHH_22770 bioB biotin synthase BioB low > 76
Escherichia coli ECRC101 0.50 MCAODC_21085 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 MCAODC_25615 bioB biotin synthase BioB 0.48 15
Escherichia coli ECRC100 0.50 OKFHMN_24075 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 OKFHMN_06400 bioB biotin synthase BioB low > 79
Klebsiella michiganensis M5al 0.50 BWI76_RS19375 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 BWI76_RS08760 biotin synthase 0.16 51
Enterobacter sp. TBS_079 0.50 MPMX20_03076 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.60 MPMX20_01403 Biotin synthase 0.38 20
Escherichia fergusonii Becca 0.50 EFB2_01754 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.60 EFB2_03330 Biotin synthase low > 86
Escherichia coli ECOR38 0.50 HEPCGN_02760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 HEPCGN_01640 bioB biotin synthase BioB low > 88
Escherichia coli BL21 0.50 ECD_02031 hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase 0.61 ECD_00742 biotin synthase low > 61
Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868 0.50 GFF3834 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.61 GFF671 Biotin synthase (EC 2.8.1.6) low > 78
Rahnella sp. WP5 0.50 EX31_RS20390 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 EX31_RS23695 biotin synthase BioB 0.58 3
Serratia liquefaciens MT49 0.50 IAI46_19100 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.60 IAI46_06525 biotin synthase BioB low > 86
Erwinia tracheiphila HP pepo 2.2 0.50 IJEDHG_18705 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 IJEDHG_19565 bioB biotin synthase BioB — —
Erwinia tracheiphila SCR3 0.49 LU632_RS08590 thiD bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 LU632_RS09130 bioB biotin synthase BioB — —
Klebsiella pneumoniae MKP103 0.49 KDGMDA_26425 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 KDGMDA_17025 biotin synthase BioB low > 95
Escherichia coli Nissle 1917 0.49 ECOLIN_RS12335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.60 ECOLIN_RS04130 biotin synthase BioB — —
Dickeya dadantii 3937 0.49 DDA3937_RS15335 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 DDA3937_RS08510 biotin synthase BioB 0.72 22
Pantoea agglomerans CFBP13505 P0401 0.48 PagCFBP13505_RS00915 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.62 PagCFBP13505_RS03770 biotin synthase BioB low > 74
Dickeya dianthicola 67-19 0.48 HGI48_RS15410 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 HGI48_RS08675 biotin synthase BioB 0.73 51
Dickeya dianthicola ME23 0.48 DZA65_RS16235 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.61 DZA65_RS08965 biotin synthase BioB 0.69 49
Pantoea sp. MT58 0.47 IAI47_06810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.62 IAI47_13530 biotin synthase BioB low > 76
Erwinia amylovora T8 0.46 OLJFJH_11930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.62 OLJFJH_16760 biotin synthase BioB low > 58
Paraburkholderia sabiae LMG 24235 0.46 QEN71_RS06305 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.57 QEN71_RS01085 biotin synthase BioB — —
Echinicola vietnamensis KMM 6221, DSM 17526 0.45 Echvi_0215 phosphomethylpyrimidine kinase 0.50 Echvi_2566 biotin synthetase low > 79
Burkholderia phytofirmans PsJN 0.45 BPHYT_RS12250 phosphomethylpyrimidine kinase 0.56 BPHYT_RS02150 biotin synthase — —
Parabacteroides merdae CL09T00C40 0.45 HMPREF1078_RS03470 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.27 HMPREF1078_RS15300 biotin synthase BioB low > 61
Vibrio cholerae E7946 ATCC 55056 0.44 CSW01_06545 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.59 CSW01_05645 biotin synthase low > 62
Paraburkholderia graminis OAS925 0.43 ABIE53_002529 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.56 ABIE53_000577 biotin synthase — —
Rhizobium sp. OAE497 0.43 ABIE40_RS25930 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.68 ABIE40_RS21075 biotin synthase BioB low > 107
Phocaeicola vulgatus CL09T03C04 0.43 HMPREF1058_RS06820 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.25 HMPREF1058_RS17950 biotin synthase BioB 0.69 50
Cellulophaga baltica 18 0.42 M666_RS03830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.49 M666_RS03345 biotin synthase BioB — —
Methylophilus sp. DMC18 0.41 GFF892 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.54 GFF1682 Biotin synthase — —
Castellaniella sp019104865 MT123 0.41 ABCV34_RS14505 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.57 ABCV34_RS15280 biotin synthase BioB — —
Hydrogenophaga sp. GW460-11-11-14-LB1 0.41 GFF249 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.53 GFF3992 Biotin synthase (EC 2.8.1.6) low > 90
Pedobacter sp. GW460-11-11-14-LB5 0.40 CA265_RS24160 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.50 CA265_RS09475 biotin synthase BioB low > 88
Acidovorax sp. GW101-3H11 0.39 Ac3H11_1063 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.52 Ac3H11_2272 Biotin synthase (EC 2.8.1.6) — —
Rhodanobacter sp000427505 FW510-R12 0.38 LRK53_RS03825 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.54 LRK53_RS03040 biotin synthase BioB low > 59
Mucilaginibacter yixingensis YX-36 DSM 26809 0.36 ABZR88_RS08810 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.51 ABZR88_RS10190 biotin synthase BioB low > 71
Desulfovibrio vulgaris Hildenborough JW710 0.36 DVU0931 thiD phosphomethylpyrimidine kinase (TIGR) 0.25 DVU2558 bioB biotin synthase (Dmitry Rodionov) — —
Dyella japonica UNC79MFTsu3.2 0.36 ABZR86_RS00760 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.56 ABZR86_RS15840 biotin synthase BioB — —
Variovorax sp. OAS795 0.35 ABID97_RS15330 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.53 ABID97_RS13955 biotin synthase BioB — —
Ralstonia solanacearum IBSBF1503 0.35 RALBFv3_RS09905 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.57 RALBFv3_RS10465 biotin synthase BioB — —
Ralstonia solanacearum UW163 0.35 UW163_RS03675 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.57 UW163_RS03115 biotin synthase BioB — —
Ralstonia sp. UNC404CL21Col 0.35 ABZR87_RS04830 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.57 ABZR87_RS06265 biotin synthase BioB — —
Ralstonia solanacearum GMI1000 0.34 RS_RS00495 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 RS_RS01305 biotin synthase — —
Caulobacter crescentus NA1000 Δfur 0.34 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.53 CCNA_03636 biotin synthase — —
Caulobacter crescentus NA1000 0.34 CCNA_03331 phosphomethylpyrimidine kinase/hydroxymethylpyrimidine kinase 0.53 CCNA_03636 biotin synthase — —
Xanthomonas campestris pv. campestris strain 8004 0.34 Xcc-8004.3091.1 hypothetical protein 0.56 Xcc-8004.505.1 Biotin synthase (EC 2.8.1.6) low > 74
Ralstonia solanacearum PSI07 0.34 RPSI07_RS23455 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.58 RPSI07_RS22850 biotin synthase BioB — —
Lysobacter sp. OAE881 0.33 ABIE51_RS07970 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.57 ABIE51_RS01140 biotin synthase BioB — —
Fusobacterium nucleatum SB010 0.33 HUW76_10300 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.27 HUW76_05115 biotin synthase BioB low > 35
Sphingobium sp. HT1-2 0.33 GFF2573 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.54 GFF133 Biotin synthase (EC 2.8.1.6) low > 95
Desulfovibrio vulgaris Miyazaki F 0.32 DvMF_1376 phosphomethylpyrimidine kinase (RefSeq) 0.24 DvMF_1001 biotin synthase (RefSeq) — —
Cupriavidus basilensis FW507-4G11 0.31 RR42_RS01370 phosphomethylpyrimidine kinase 0.55 RR42_RS00940 biotin synthase — —
Synechococcus elongatus PCC 7942 0.30 Synpcc7942_2379 thiD phosphomethylpyrimidine kinase 0.48 Synpcc7942_0419 bioB biotin synthase — —
Magnetospirillum magneticum AMB-1 0.29 AMB_RS16155 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.59 AMB_RS13865 biotin synthase — —
Rhodanobacter sp. FW510-T8 0.29 OKGIIK_03835 Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.55 OKGIIK_13650 bioB biotin synthase BioB low > 53
Acinetobacter baumannii LAC-4 0.28 RR41_RS15160 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.58 RR41_RS11800 biotin synthase BioB — —
Acinetobacter radioresistens SK82 0.28 MPMX26_02438 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.57 MPMX26_01785 Biotin synthase — —
Pseudomonas aeruginosa PA14 0.27 IKLFDK_20515 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.60 IKLFDK_22935 biotin synthase BioB low > 100
Sphingomonas koreensis DSMZ 15582 0.27 Ga0059261_1961 hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 0.59 Ga0059261_3989 biotin synthase (EC 2.8.1.6) — —
Dechlorosoma suillum PS 0.27 Dsui_0662 phosphomethylpyrimidine kinase 0.58 Dsui_1297 biotin synthetase — —
Pseudomonas putida KT2440 0.27 PP_4782 Phosphomethylpyrimidine kinase 0.60 PP_0362 Biotin synthase 0.57 10
Pseudomonas fluorescens FW300-N2C3 0.27 AO356_15435 hydrogenase 0.60 AO356_14135 biotin synthase 0.37 5
Pseudomonas sp. BP01 0.27 JOY50_RS21745 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.60 JOY50_RS17930 bioB biotin synthase BioB low > 84
Pseudomonas simiae WCS417 0.27 PS417_24600 hydrogenase 0.59 PS417_26005 biotin synthase low > 88
Pseudomonas sp. SVBP6 0.26 COO64_RS15485 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.61 COO64_RS22725 bioB biotin synthase BioB 0.61 69
Pseudomonas fluorescens FW300-N2E3 0.26 AO353_06350 hydrogenase 0.60 AO353_07525 biotin synthase low > 101
Pseudomonas fluorescens SBW25 0.26 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.60 PFLU_RS27650 biotin synthase BioB low > 109
Pseudomonas sp. S08-1 0.26 OH686_09185 Hydroxymethylpyrimidine phosphate kinase ThiD 0.60 OH686_10355 biotin synthase low > 80
Pseudomonas fluorescens SBW25-INTG 0.26 PFLU_RS26530 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.60 PFLU_RS27650 biotin synthase BioB 0.31 64
Mycobacterium tuberculosis H37Rv 0.26 Rv0422c Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) 0.28 Rv1589 Probable biotin synthetase BioB — —
Pseudomonas fluorescens GW456-L13 0.26 PfGW456L13_1385 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.60 PfGW456L13_1147 Biotin synthase (EC 2.8.1.6) low > 87
Pseudomonas sp. DMC3 0.26 GFF3905 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.60 GFF76 Biotin synthase low > 89
Pseudomonas syringae pv. syringae B728a 0.26 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.60 Psyr_4687 biotin synthase 0.73 6
Pseudomonas syringae pv. syringae B728a ΔmexB 0.26 Psyr_4340 phosphomethylpyrimidine kinase, putative 0.60 Psyr_4687 biotin synthase 0.68 6
Pseudomonas stutzeri RCH2 0.26 Psest_0537 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.59 Psest_0411 biotin synthetase 0.40 8
Pseudomonas segetis P6 0.25 MPMX49_01077 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.60 MPMX49_00759 Biotin synthase 0.41 45
Pseudomonas sp. RS175 0.24 PFR28_03843 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.59 PFR28_04103 Biotin synthase 0.32 79
Herbaspirillum seropedicae SmR1 0.24 HSERO_RS02135 phosphomethylpyrimidine kinase 0.52 HSERO_RS12235 biotin synthase low > 78
Pseudomonas fluorescens FW300-N1B4 0.23 Pf1N1B4_2718 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.60 Pf1N1B4_2487 Biotin synthase (EC 2.8.1.6) low > 87
Pseudomonas fluorescens FW300-N2E2 0.23 Pf6N2E2_5024 Hydroxymethylpyrimidine phosphate kinase ThiD (EC 2.7.4.7) 0.60 Pf6N2E2_4759 Biotin synthase (EC 2.8.1.6) low > 103
Pontibacter actiniarum KMM 6156, DSM 19842 0.23 CA264_20430 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.50 CA264_02425 biotin synthase BioB low > 74
Pseudomonas lactucae CFBP13502 0.23 GEMAOFIL_05068 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 0.59 GEMAOFIL_05322 Biotin synthase low > 93
Phaeobacter inhibens DSM 17395 0.19 PGA1_c09030 phosphomethylpyrimidine kinase ThiD 0.67 PGA1_c09120 biotin synthase BioB low > 62

Not shown: 13 genomes with orthologs for Atu3290 only; 13 genomes with orthologs for Atu3997 only